Referenser och källor

Nr 4 2025 — Gut-brain axis (samspelet mellan tarmen och hjärnan)

Vagusnerven - länken mellan hjärnan och magen

1. Han Y, Wang B, Gao H, He C, Hua R, Liang C, Zhang S, Wang Y, Xin S, Xu J. Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases. J Inflamm Res. 2022 Nov 9;15:6213-6230. doi: 10.2147/JIR.S384949. PMID: 36386584; PMCID: PMC9656367.
2. Décarie-Spain L, Hayes AMR, Lauer LT, Kanoski SE. The gut-brain axis and cognitive control: A role for the vagus nerve. Semin Cell Dev Biol. 2024 Mar 15;156:201-209. doi: 10.1016/j.semcdb.2023.02.004. Epub 2023 Feb 16. PMID: 36803834; PMCID: PMC10427741.
3. Steidel K et al. Transcutaneous auricular vagus nerve stimulation influences gastric motility: A randomized, double-blind trial in healthy individuals. Brain Stimulation 2021; 14:1126–1132. https://doi.org/10.1016/j.brs.2021.06.006
4. Accettulli A, Corbo MR, Sinigaglia M, Speranza B, Campaniello D, Racioppo A, Altieri C, Bevilacqua A. Psycho-Microbiology, a New Frontier for Probiotics: An Exploratory Overview. Microorganisms. 2022 Oct 29;10(11):2141.
5. Costa PCT, de Luna Freire MO, de Oliveira Coutinho D, Godet M, Magnani M, Antunes VR, de Souza EL, Vidal H, de Brito Alves JL. Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review. Pharmacol Res. 2024 Oct;208:107368. doi: 10.1016/j.phrs.2024.107368. Epub 2024 Aug 25. PMID: 39191337.
6. Lasselin J, Benson S, Hebebrand J, Boy K, Weskamp V, Handke A, Hasenberg T, Remy M, Föcker M, Unteroberdörster M, Brinkhoff A, Engler H, Schedlowski M. Immunological and behavioral responses to in vivo lipopolysaccharide administration in young and healthy obese and normal-weight humans. Brain Behav Immun. 2020 Aug;88:283-293.
7. Millischer V, Heinzl M, Faka A, Resl M, Trepci A, Klammer C, Egger M, Dieplinger B, Clodi M, Schwieler L. Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial. J Neuroinflammation. 2021 Jul 17;18(1):158
8. Koga-Batko J, Antosz-Popiołek K, Suchecki W, Szyller H, Wrześniewska M, Dyda M, Leszek J. Influence of the Gut Microbiota on the Pathogenesis of Alzheimer’s Disease: A Literature Review. Cells. 2025 Oct 11;14(20):1578. doi: 10.3390/cells14201578. PMID: 41148793; PMCID: PMC12564258.
9. Sgritta M, Dooling SW, Buffington SA, et al. Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder. Neuron. 2019;101 (2) :246–259. e246. doi:10.1016/j.neuron.2018.11.018
10. Liu S, Cheng L, Liu Y, Zhan S, Wu Z, Zhang X. Relationship between Dietary Polyphenols and Gut Microbiota: New Clues to Improve Cognitive Disorders, Mood Disorders and Circadian Rhythms. Foods. 2023 Mar 19;12(6):1309. doi: 10.3390/foods12061309. PMID: 36981235; PMCID: PMC10048542.
11. Kiecolt-Glaser JK. Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosom Med. 2010 May;72(4):365-9. doi: 10.1097/PSY.0b013e3181dbf489. Epub 2010 Apr 21. PMID: 20410248; PMCID: PMC2868080.
12. Bruning J, Chapp A, Kaurala GA, Wang R, Techtmann S, Chen QH. Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System. Neurosci Bull. 2020 Jan;36(1):91-95. doi: 10.1007/s12264-019-00410-8. Epub 2019 Jul 12. PMID: 31301036; PMCID: PMC6940411.
13. Teichmann J, Cockburn DW. In vitro Fermentation Reveals Changes in Butyrate Production Dependent on Resistant Starch Source and Microbiome Composition. Front Microbiol. 2021 Apr 29;12:640253. doi: 10.3389/fmicb.2021.640253. PMID: 33995299; PMCID: PMC8117019.

När magen rubbar din dygnsrytm – kopplingen mellan sömn och tarmhälsa

1.Han M, Yuan S, Zhang J. The interplay between sleep and gut microbiota. Brain Res Bull. 2022 Mar;180:131-146.
2. Smith RP, Easson C, Lyle SM, Kapoor R, Donnelly CP, Davidson EJ, Parikh E, Lopez JV, Tartar JL. Gut microbiome diversity is associated with sleep physiology in humans. PLoS One. 2019 Oct 7;14(10):e0222394.
3.Li Y, Zhang B, Zhou Y, Wang D, Liu X, Li L, Wang T, Zhang Y, Jiang M, Tang H, Amsel LV, Fan F, Hoven CW. Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia. Nat Sci Sleep. 2020 Nov 5;12:895-905.
4.Liu Y, Zhang L, Yang C, Zhi L, Steven Xu X, Yuan M. Oral microbiome diversity shapes the association between sleep duration and depression. Front Neurol. 2024 Sep 13;15:1442557.
5.Kim MH, Yun KE, Kim J, Park E, Chang Y, Ryu S, Kim HL, Kim HN. Gut microbiota and metabolic health among overweight and obese individuals. Sci Rep. 2020 Nov 10;10(1):19417.
6.Wankhede NL, Kale MB, Kyada A, M RM, Chaudhary K, Naidu KS, Rahangdale S, Shende PV, Taksande BG, Khalid M, Gulati M, Umekar MJ, Fareed M, Kopalli SR, Koppula S. Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders. Neuroscience. 2025 Jan 26;565:99-116.
7.Bermingham KM, Stensrud S, Asnicar F, Valdes AM, Franks PW, Wolf J, Hadjigeorgiou G, Davies R, Spector TD, Segata N, Berry SE, Hall WL. Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort. Eur J Nutr. 2023 Dec;62(8):3135-3147.
8.Rusch JA, Layden BT, Dugas LR. Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis. Front Endocrinol (Lausanne). 2023 Jun 19;14:1130689.
9.Li Y, Zhang B, Zhou Y, Wang D, Liu X, Li L, Wang T, Zhang Y, Jiang M, Tang H, Amsel LV, Fan F, Hoven CW. Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia. Nat Sci Sleep. 2020 Nov 5;12:895-905.
10.Rusch JA, Layden BT, Dugas LR. Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis. Front Endocrinol (Lausanne). 2023 Jun 19;14:1130689.
11.Wang Z, Wu T, Li J, Lu T, Yu Y, Guan Z, Yuan G, Lv Z, Shan Y, Yan W, Liu X, Vitiello MV, Yin Q, Sun J, Lu L. Brain-gut-microbiota interactions in sleep disorders. Brain Medicine, Nov 2025.
12.Szentirmai É, Millican NS, Massie AR, Kapás L. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Sci Rep. 2019 May 7;9(1):7035.
13.Xing C, Huang X, Wang D, Yu D, Hou S, Cui H, Song L. Roles of bile acids signaling in neuromodulation under physiological and pathological conditions. Cell Biosci. 2023 Jun 12;13(1):106.
14.Gill PA, Inniss S, Kumagai T, Rahman FZ, Smith AM. The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease. Front Immunol. 2022 Apr 5;13:866059.
15.Brandão LEM, Popa A, Cedernaes E, Cedernaes C, Lampola L, Cedernaes J. Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial. Obesity (Silver Spring). 2023 Jul;31(7):1755-1766.
16.Shanmugasundaram S, Karmakar S. Excess dietary sugar and its impact on periodontal inflammation: a narrative review. BDJ Open. 2024 Oct 9;10(1):78.
17.Nonaka K, Nakazawa Y, Kotorii T. Effects of antibiotics, minocycline and ampicillin, on human sleep. Brain Res. 1983 Dec 12;288(1-2):253-9.
18.O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015 Jan 15;277:32-48.
19.Dos Santos A, Galiè S. The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review. Nutrients. 2024 Jan 29;16(3):390.
20.Konturek SJ, Konturek PC, Brzozowska I, Pawlik M, Sliwowski Z, Cześnikiewicz-Guzik M, Kwiecień S, Brzozowski T, Bubenik GA, Pawlik WW. Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT). J Physiol Pharmacol. 2007 Sep;58(3):381-405.
21.Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci. 2002 Oct;47(10):2336-48.
22.Tang J, Krushelnycky L, Shaqo A, Cho CE. A Comprehensive Review of Nutritional Influences on the Serotonergic System. Adv Nutr. 2025 Nov;16(11):100524.
23..Jackson ML, Butt H, Ball M, Lewis DP, Bruck D. Sleep quality and the treatment of intestinal microbiota imbalance in chronic fatigue syndrome: a pilot study. Sleep Sci. 2015;8(3):124–133.
24.Makki K, Deehan EC, Walter J, Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host Microbe. 2018 Jun 13;23(6):705-715.
25.Armet AM, Deehan EC, O’Sullivan AF, Mota JF, Field CJ, Prado CM, Lucey AJ, Walter J. Rethinking healthy eating in light of the gut microbiome. Cell Host Microbe. 2022 Jun 8;30(6):764-785.
26.Sampsell K, Marcolla CS, Tapping S, Fan Y, Sánchez-Lafuente CL, Willing BP, Reimer RA, Burton JP. Current Research in Fermented Foods: Bridging Tradition and Science. Adv Nutr. 2025 Nov 11:100554.
27.Liu Y, Chen Y, Zhang Q, Zhang Y, Xu F. A double blinded randomized placebo trial of Bifidobacterium animalis subsp. lactis BLa80 on sleep quality and gut microbiota in healthy adults. Sci Rep. 2025 Apr 1;15(1):11095.
28.Moloney GM, Long-Smith CM, Murphy A, Dorland D, Hojabri SF, Ramirez LO, Marin DC, Bastiaanssen TFS, Cusack AM, Berding K, Fouhy F, Allen AP, Stanton C, Clarke G, Dinan TG, Cryan JF. Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum. Brain Behav Immun Health. 2020 Nov 13;10:100174.
29.Takada M, Nishida K, Gondo Y, Kikuchi-Hayakawa H, Ishikawa H, Suda K, Kawai M, Hoshi R, Kuwano Y, Miyazaki K, Rokutan K. Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial. Benef Microbes. 2017 Apr 26;8(2):153-162.
30.Szentirmai É, Millican NS, Massie AR, Kapás L. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Sci Rep. 2019 May 7;9(1):7035.

Kan probiotika minska depression och stress?

Tryptofanets väg till hjärnan – nyckeln till mentalt välmående?

1. Miri S, Yeo J, Abubaker S, Hammami R. Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome? Front Microbiol. 2023 Jan 17;14:1098412. doi: 10.3389/fmicb.2023.1098412. PMID: 36733917; PMCID: PMC9886687.
2. Chatterjee, R. (värd för podcast). (2022, Juli 12). Tim Spector: The latest science on gut health (and how to find the right diet for you) #291 [Podcastavsnitt]. Feel Better, Live More.
3. Agus A, Planchais J, Sokol H. Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. Cell Host Microbe. 2018 Jun 13;23(6):716-724. doi: 10.1016/j.chom.2018.05.003. PMID: 29902437.
4. Serafini G, Adavastro G, Canepa G, Capobianco L, Conigliaro C, Pittaluga F, Murri MB, Valchera A, De Berardis D, Pompili M, Lindqvist D, Brundin L, Amore M. Abnormalities in Kynurenine Pathway Metabolism in Treatment-Resistant Depression and Suicidality: A Systematic Review. CNS Neurol Disord Drug Targets. 2017;16(4):440-453. doi: 10.2174/1871527316666170413110605. PMID: 28412922.
5. Hendrikx T, Schnabl B. Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation. J Intern Med. 2019 Jul;286(1):32-40. doi: 10.1111/joim.12892. Epub 2019 Mar 14. PMID: 30873652.
6. Li X, Zhang B, Hu Y, Zhao Y. New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases. Front Pharmacol. 2021 Dec 13;12:769501. doi: 10.3389/fphar.2021.769501. PMID: 34966278; PMCID: PMC8710772.
7. Mir HD, Yang Q, Maximin E, Montardy Q, Ji S, Cheng Q, Shan X, Wang L, Naudon L, Rabot S, Li L. Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation. Neurobiol Dis. 2024 Oct 1;200:106606. doi: 10.1016/j.nbd.2024.106606. Epub 2024 Jul 15. PMID: 39019292.
8. Sakurai T, Odamaki T, Xiao JZ. Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants. Microorganisms. 2019 Sep 11;7(9):340. doi: 10.3390/microorganisms7090340. PMID: 31514325; PMCID: PMC6780619.
9. Zhou Y, Chen Y, He H, Peng M, Zeng M, Sun H. The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases. Neuropharmacology. 2023 Nov 15;239:109690. doi: 10.1016/j.neuropharm.2023.109690. Epub 2023 Aug 22. PMID: 37619773.
10. Yu W, Xiao Y, Jayaraman A, Yen YC, Lee HU, Pettersson S, Je HS. Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors. EMBO Mol Med. 2025 Feb;17(2):249-264. doi: 10.1038/s44321-024-00179-y. Epub 2025 Feb 5. PMID: 39910348; PMCID: PMC11821874.
11. https://www.sciencedaily.com/releases/2025/02/250205165613.htm
12. Brydges CR, Fiehn O, Mayberg HS, Schreiber H, Dehkordi SM, Bhattacharyya S, Cha J, Choi KS, Craighead WE, Krishnan RR, Rush AJ, Dunlop BW, Kaddurah-Daouk R; Mood Disorders Precision Medicine Consortium. Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature. Sci Rep. 2021 Oct 25;11(1):21011. doi: 10.1038/s41598-021-99845-1. PMID: 34697401; PMCID: PMC8546034.
13. Wang X, Hu M, Wu W, Lou X, Gao R, Ma T, Dheen ST, Cheng J, Xiong J, Chen X, Wang J. Indole derivatives ameliorated the methamphetamine-induced depression and anxiety via aryl hydrocarbon receptor along ”microbiota-brain” axis. Gut Microbes. 2025 Dec;17(1):2470386. doi: 10.1080/19490976.2025.2470386. Epub 2025 Feb 25. PMID: 39996473; PMCID: PMC11864316.
14. Lukić I, Ivković S, Mitić M, Adžić M. Tryptophan metabolites in depression: Modulation by gut microbiota. Front Behav Neurosci. 2022 Sep 12;16:987697. doi: 10.3389/fnbeh.2022.987697. PMID: 36172468; PMCID: PMC9510596.
15. Thaoboonruang N, Lohitnavy M, Lohitnavy O. Pharmacokinetics of Psilocybin, a Tryptamine Alkaloid in Magic Mushroom (Psilocybe cubensis): A Systematic Review. J Psychoactive Drugs. 2025 Sep-Oct;57(4):386-398. doi:
16. 10.1080/02791072.2024.2399128. Epub 2024 Sep 10. PMID: 39257234.
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2023 Aug;28(8):3243-3256. doi: 10.1038/s41380-022-01661-0. Epub 2022 Jul 20. PMID: 35854107; PMCID

SIBO OCH LÄCKANDE TARM ”Det viktiga är inte vilka bakterier du har – utan i vilken tarm de sitter”

1. Kirkin AF, Dzhandzhugazyan KN, Guldberg P, Walter MR, Olsen LR, Fischer W, et al. Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells. Nat Commun. 2018 Mar 6;9:785. doi:10.1038/s41467-018-03217-9.
https://pubmed.ncbi.nlm.nih.gov/29511178/

2. Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, et al. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors. Science. 2018 Jan 5;359(6371):91-97. doi:10.1126/science.aan3706.
https://pubmed.ncbi.nlm.nih.gov/29097494/
3. Banaszak M., et al. Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO. Microorganisms. 2023 Feb 24;11(3):573. Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO.
https://pubmed.ncbi.nlm.nih.gov/36985147/
4. Chae YR, Lee YR, Kim YS, Park HY. Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome. J Microbiol Biotechnol. 2024 Apr 28;34(4):747-756. Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome.
https://pubmed.ncbi.nlm.nih.gov/38321650/
5. Kinashi Y, Hase K. Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity. Front Immunol. 2021 Apr 15;12:673708. doi:10.3389/fimmu.2021.673708.
https://pubmed.ncbi.nlm.nih.gov/33968085/
6. Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer. Physiol Rev, 91(1):151–175.
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7. Kowalski & Mulak. (2019). Brain–Gut–Microbiota Axis in Alzheimer’s Disease. Nutrients, 11(12):2825. Sampson et al. (2016). Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, 167(6):1469–1480.e12). Blacher, E., Bashiardes, S., Shapiro, H. et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572, 474–480 (2019). Wu, S., Yi, J., Zhang, Y. G., Zhou, J., & Sun, J. (2015). Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. Physiological reports, 3(4), e12356.
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8. Bushyhead D, Quigley EMM. Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management. Gastroenterology 2022; 163: 593-607. Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management.
https://pubmed.ncbi.nlm.nih.gov/35398346/
9. Lauritano EC, Gabrielli M, Scarpellini E, Lupascu A, Novi M, Sottili S, Vitale G, Cesario V, Serricchio M, Cammarota G, Gasbarrini G, Gasbarrini A. Small intestinal bacterial overgrowth recurrence after antibiotic therapy. Am J Gastroenterol. 2008 Aug;103(8):2031-5. Small intestinal bacterial overgrowth recurrence after antibiotic therapy.
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10. Chen B, Kim JJ, Zhang Y, Du L, Dai N. Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systematic review and meta-analysis. J Gastroenterol. 2018 Jul;53(7):807-818.
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11. Chedid V., et al. Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth. Glob Adv Health Med. 2014; 3(3): 16–24. Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth.
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12. Riordan SM, McIver CJ, Walker BM, Duncombe VM, Bolin TD, Thomas MC. The lactulose breath hydrogen test and small intestinal bacterial overgrowth. Scand J Gastroenterol. 1997 Jun;32(6):485-90. doi:10.3109/00365529709025090.
https://pubmed.ncbi.nlm.nih.gov/8792701/

13. Losurdo G, Ierardi E, Marra A, Giorgio F, Covelli C, Di Leo A, Principi M. Breath tests for the non-invasive diagnosis of small intestinal bacterial overgrowth: a systematic review with meta-analysis. J Neurogastroenterol Motil. 2020 Jan 30;26(1):16-28. doi:10.5056/jnm19113.

https://pubmed.ncbi.nlm.nih.gov/31743632/

14. https://gut.bmj.com/content/69/11/2117
15.https://www.frontiersin.org/articles/10.3389/falgy.2024.1505834
16. https://www.mdpi.com/2077-0383/13/4/1044
17. https://www.mdpi.com/2072-6643/15/3/672
18.https://link.springer.com/article/10.1007/s11739-023-03374-w
19. https://www.mdpi.com/2076-2607/10/3/386

Salt kan påverka vikt och fettförbränning

1. Wuopio J, Yi-Ting L, Dekkers KF, Fall T, Smith JG, Larsson A, Engström G, Orho-Melander M, Johnson LS, Ärnlöv J. The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study. Nutr Metab (Lond). 2025 Sep 2;22(1):104.
2. Zhang Y, Li F, Liu FQ, Chu C, Wang Y, Wang D et al. Elevation of fasting Ghrelin in healthy human subjects consuming a High-Salt diet: A novel mechanism of obesity? Nutrients. 2016;8(6).
3. Zheng WL, Chu C, Lv YB, Wang Y, Hu JW, Ma Q, et al. Effect of salt intake on serum Glucagon-Like Peptide-1 levels in normotensive salt-Sensitive sub- jects. Kidney Blood Press Res. 2017;42(4):728–37.
4. Lee M, Sorn SR, Lee Y, Kang I. Salt induces adipogenesis/lipogenesis and inflammatory adipocytokines secretion in adipocytes. Int J Mol Sci. 2019;20(1).
5. Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, et al. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous Fructose production and metabolism. Proc Natl Acad Sci U S A. 2018;115(12):3138–43.
6. Dobrian AD, Schriver SD, Lynch T, Prewitt RL. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity. Am J Physiol Ren Physiol. 2003;285(4):F619–28.
7. Fonseca-Alaniz MH, Brito LC, Borges-Silva CN, Takada J, Andreotti S, Lima FB. High dietary sodium intake increases white adipose tissue mass and plasma leptin in rats. Obes (Silver Spring). 2007;15(9):2200–8.

Kortisonabstinens – en komplex och kontroversiell hudåkomma

1.Topical Steroid Withdrawal. British Association of Dermatologists, British Dermatological Nursing Group, National Eczema Society, 2024. https://cdn.bad.org.uk/uploads/2024/02/22095550/Topical-Steroid-Withdrawal-Joint-Statement.pdf.
2.Alsterholm M., af Klinteberg M., Vrang S, Sigurdardottir G., et al. Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire. Acta Derm Venereol 2025: 105. DOI https://medicaljournalssweden.se/actadv/article/view/40187
3.Maskey A.R., Sasaki A., Sargen M., et.al. Breaking the cycle: a comprehensive exploration of topical steroid addiction and withdrawal. Front Allergy. 2025:31;6 DOI: 10.3389/falgy.2025.1547923
4.Rios-Carlos M., Cervantes-García D., Córdova-Dávalos L.E., et al. Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies. Gut Microbes. 2024:16 DOI: https://doi.org/10.1080/19490976.2024.2430420
5.Mao R., Men X., Zhang T., et al. Evaluating the Impact of Omega-3 Fatty Acids and Genetic Susceptibility on Atopic Dermatitis in Adults. Molecular Nutrition & Food Research. 2025:69;7 DOI: https://doi.org/10.1002/mnfr.70002
6.Ying Nielsen A., Høj S., Thomsen S.F., Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024:16;23 DOI: 10.3390/nu16234128
7.Chiu C-Y., Yang C-H., Su K-W., et al. Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood. Journal of Microbiology, Immunology and Infection. 2020:53;6 DOI: https://doi.org/10.1016/j.jmii.2019.04.007
8.Weimer D.S., Beckler M.D. Underlying Immune Mechanisms Involved in Cow’s Milk-Induced Hypersensitivity Reactions Manifesting as Atopic Dermatitis. Cureus. 2022:14;8 DOI: 10.7759/cureus.27604
9.Sun S., Chang G., Zhang L. The prevention effect of probiotics against eczema in children: an update systematic review and meta-analysis. Journal of Dermatological Treatment. 2022:33;4 DOI: https://doi.org/10.1080/09546634.2021.1925077

Brist på selen kan förklara ett försvagat immunförsvar

1. Am J Clin Nutr 2004;80:154–62.

2. Free Radical Biology and Medicine, Volume 42, Issue 12, 15 June 2007, Pages 1826–1837

3. Livsmedelsverket, 2024: https://www.livsmedelsverket.se/

4. Nutrients 2015 Jan 15;7(1):608–24

5. Int J Cardiol, 2013 Sep 1;167(5):1860–6

Nr 3 2025 — Metabol hälsa

Hur väl fungerar din metabolism? Så tolkar du dina värden

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5. Matthews, D.R., et al. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412–419.

6. Monnier, L., et al. (2007). Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 295(14), 1681–1687.

Den muskelcentriska synen ”Bygga muskler viktigare än att minska kroppsfett”

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Krononutrition, Tajma måltiderna för optimal hälsa

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6. Franzago M, Alessandrelli E, Notarangelo S, Stuppia L, Vitacolonna E. Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition. Int J Mol Sci. 2023 Jan 29;24(3):2571.

7. López-Prieto RS, Romo-Romo A, Gómez-Avilés P, Sharma-Sharma S, Costilla-Orozco X, Galán-Ramírez GA, Almeda-Valdés P. Time matters: an insight into the relationship between chrononutrition and diabetes. Rev Invest Clin. 2024 Apr 3;76(2):080-090.

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9. Sherman, H.; Genzer, Y.; Cohen, R.; Chapnik, N.; Madar, Z.; Froy, O. Timed high-fat diet

10. Chaix, A.; Zarrinpar, A.; Miu, P.; Panda, S. Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges. Cell Metab. 2014, 20, 991–1005.

11. Adamovich, Y.; Rousso-Noori, L.; Zwighaft, Z.; Neufeld-Cohen, A.; Golik, M.; Kraut-Cohen, J.; Wang, M.; Han, X.; Asher, G. Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides. Cell Metab. 2014, 19, 319–330.

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Högt LDL behöver inte leda till åderförkalkning hos friska personer

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Myten om 8 timmars ostörd sömn

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3. Yetish G, Kaplan H, Gurven M. Sleep variability and nighttime activity among Tsimane forager-horticulturalists. Am J Phys Anthropol. 2018 Jul;166(3):590-600.

Finns nyckeln till hälsosam vikt i vår tarmflora?

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4. Carmody RN, Bisanz JE. Roles of the gut microbiome in weight management. Nat Rev Microbiol. 2023 Aug;21(8):535-550.

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10. Seck EH, Senghor B, Merhej V, Bachar D, Cadoret F, Robert C, et al. Salt in stools is associated with obesity, gut halophilic microbiota and Akkermansia muciniphila depletion in humans. Int J Obes. (2019) 43:862–71.

11. Zhang Y, Liu R, Chen Y, Cao Z, Liu C, Bao R, Wang Y, Huang S, Pan S, Qin L, Wang J, Ning G, Wang W. Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut. Cell Metab. 2025 Mar 4;37(3):592-605.e6.

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Stress påverkar ämnesomsättningen och bidrar till fettinlagring

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Kroppens aptitbroms – så fungerar GLP-1

1. Mariam-Smith A, Breeyear JH, Daniels NJ, Pantalone KM, Griebeler ML, Motsinger-Reif AA, Rotroff DM. Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss. Diabetes Obes Metab. 2025 Jul 18.

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3. Bodnaruc AM, Prud’homme D, Blanchet R, Giroux I. Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review. Nutr Metab (Lond). 2016 Dec 9;13:92.

4. Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, Bonnet J, Butsch WS, Christensen S, Gianos E, Gulati M, Gupta A, Horn D, Kane RM, Saluja J, Sannidhi D, Stanford FC, Callahan EA. Nutritional priorities to support GLP-1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Obesity (Silver Spring). 2025 Aug;33(8):1475-1503.

5. Hamasaki H. Exercise and glucagon-like peptide-1: Does exercise potentiate the effect of treatment? World J Diabetes. 2018 Aug 15;9(8):138-140.

Bitterörter – naturens Ozempic

1. Kim KS, Egan JM, Jang HJ. Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia. 2014 Oct;57(10):2117-25.

2. Pham H, Hui H, Morvaridi S, Cai J, Zhang S, Tan J, Wu V, Levin N, Knudsen B, Goddard WA 3rd, Pandol SJ, Abrol R. A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells. Biochem Biophys Res Commun. 2016 Jul 1;475(3):295-300.

3. Lee SH, Ko HM, Jee W, Kim H, Chung WS, Jang HJ. Isosinensetin Stimulates Glucagon-like Peptide-1 Secretion via Activation of hTAS2R50 and the Gβγ-Mediated Signaling Pathway. Int J Mol Sci. 2023 Feb 12;24(4):3682.

4. Xie C, Wang X, Young RL, Horowitz M, Rayner CK, Wu T. Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control. Front Endocrinol (Lausanne). 2018 Sep 27;9:576.

5. Chou WL. Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia. Pharmacol Res. 2021 Aug;170:105693.

6. Yang WL, Zhang CY, Ji WY, Zhao LL, Yang FY, Zhang L, Cao X. Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction. Am J Chin Med. 2024;52(1):253-274.

7. Araj-Khodaei M, Ayati MH, Azizi Zeinalhajlou A, Novinbahador T, Yousefi M, Shiri M, Mahmoodpoor A, Shamekh A, Namazi N, Sanaie S. Berberine-induced glucagon-like peptide-1 and its mechanism for controlling type 2 diabetes mellitus: a comprehensive pathway review. Arch Physiol Biochem. 2024 Dec;130(6):678-685.

8. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008 May;57(5):712-7.

9. Sun S, Yang Y, Xiong R, Ni Y, Ma X, Hou M, Chen L, Xu Z, Chen L, Ji M. Oral berberine ameliorates high-fat diet-induced obesity by activating TAS2Rs in tuft and endocrine cells in the gut. Life Sci. 2022 Dec 15;311(Pt A):121141.

10. Utami AR, Maksum IP, Deawati Y. Berberine and Its Study as an Antidiabetic Compound. Biology (Basel). 2023 Jul 8;12(7):973.

11. Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2017 Sep 11;9(11):10135-10146.

12. Huang TN, Lu KN, Pai YP, Chin Hsu, Huang CJ. Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd. Evid Based Complement Alternat Med. 2013;2013:625892.

13. Habicht SD, Ludwig C, Yang RY, Krawinkel MB. Momordica charantia and type 2 diabetes: from in vitro to human studies. Curr Diabetes Rev. 2014 Jan;10(1):48-60.

14. Kim B, Lee HS, Kim HJ, Lee H, Lee IY, Ock S, Kwon S, Kang SS, Choi Y. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol. 2022 Dec 14;32(5):697-704.

15. Mes JJ, van den Belt M, van der Haar S, Oosterink E, Luijendijk T, Manusama K, van Dam L, de Bie T, Witkamp R, Esser D. Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a prediabetic population. J Ethnopharmacol. 2025 May 12;347:119756.

16. Krawinkel MB, Ludwig C, Swai ME, Yang RY, Chun KP, Habicht SD. Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania. J Ethnopharmacol. 2018 Apr 24;216:1-7.

17. Liu Z, Gong J, Huang W, Lu F, Dong H. The Effect of Momordica charantia in the Treatment of Diabetes Mellitus: A Review. Evid Based Complement Alternat Med. 2021 Jan 16;2021:3796265.

18. Suh HW, Lee KB, Kim KS, Yang HJ, Choi EK, Shin MH, Park YS, Na YC, Ahn KS, Jang YP, Um JY, Jang HJ. A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse. J Ethnopharmacol. 2015 Aug 22;172:219-26.

19. Choi R-Y, Nam S-J, Lee H-I, Lee J, Leutou AS, Ri Ham J. et al. Gentiopicroside isolated from Gentiana scabra Bge. inhibits adipogenesis in 3T3-L1 cells and reduces body weight in diet-induced obese mice. Bioorg Med Chem Lett. 2019;29:1699–704.
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21. Walker EG, Lo KR, Pahl MC, Shin HS, Lang C, Wohlers MW, Poppitt SD, Sutton KH, Ingram JR. An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial. Am J Clin Nutr. 2022 Mar 4;115(3):925-940.

22. Walker E, Lo K, Gopal P. Gastrointestinal delivery of bitter hop extract reduces appetite and food cravings in healthy adult women undergoing acute fasting. Obes Pillars. 2024 Jun 20;11:100117.

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27. Pressmeddelande: https://polyphenols-site.com/polyphenols-in-press-media/970-polyphenols-to-replace-current-glp-1-drugs-targeting-obesity-and-diabetes

Processad & lagrad mat triggar inflammation och sjukdom

1. Phuong-Nguyen K, McNeill BA, Aston-Mourney K, Rivera LR. Advanced Glycation End-Products and Their Effects on Gut Health. Nutrients. 2023 Jan 13;15(2):405.

2. Nicholl, I.D.; Stitt, A.W.; Moore, J.E.; Ritchie, A.J.; Archer, D.B.; Bucala, R. Increased Levels of Advanced Glycation Endproducts in the Lenses and Blood Vessels of Cigarette Smokers. Mol. Med. 1998, 4, 594–601.

3. Uribarri J, Cai W, Peppa M, Goodman S, Ferruci L, Striker G, Vlassara H. Circulating glycotoxins and dietary advanced glycation end-products: Two links to inflammatory response oxidative stress, and aging. J Gerontol A Biol Sci Med Sci. 2007; 62:427–433.

4. Heidland A, Sebekova K, Schinzel R. Advanced glycation end products and the progressive course of renal disease. Am. J. Kidney Dis. 2001;38:S100–106.

5. Yamagishi SI, Matsui T. Role of hyperglycemia-induced advanced glycation end product (AGE) accumulation in atherosclerosis. Ann. Vasc. Dis. 2018;11:253–258.

6. Shiraki M, Kashiwabara S, Imai T, Tanaka S, Saito M. The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women. J. Bone Miner. Metab. 2019;37:1067–1074.

7. Eguchi, Y.; Toyoguchi, T.; Inage, K.; Fujimoto, K.; Orita, S.; Suzuki, M.; Kanamoto, H.; Abe, K.; Norimoto, M.; Umimura, T.; et al. Advanced glycation end products are associated with sarcopenia in older women: Aging marker dynamics. J. Women Aging 2021, 33, 328–340.

8. Stig Bengmark, Vår tids kost bakom inflammation och sjukdomsutveckling, Läkartidningen nr 51–52 2007 volym 104.

9. van Dooren, F.E.P.; Pouwer, F.; Schalkwijk, C.G.; Sep, S.J.S.; Stehouwer, C.D.A.; Henry, R.M.A.; Dagnelie, P.C.; Schaper, N.C.; van der Kallen, C.J.H.; Koster, A.; et al. Advanced Glycation End Product (AGE) Accumulation in the Skin is Associated with Depression: The Maastricht Study. Depress. Anxiety 2016, 34, 59–67.

10. Miyashita, M.; Yamasaki, S.; Ando, S.; Suzuki, K.; Toriumi, K.; Horiuchi, Y.; Yoshikawa, A.; Imai, A.; Nagase, Y.; Miyano, Y.; et al. Fingertip advanced glycation end products and psychotic symptoms among adolescents. Schizophrenia 2021, 7, 37.

11. Kobori, A.; Miyashita, M.; Miyano, Y.; Suzuki, K.; Toriumi, K.; Niizato, K.; Oshima, K.; Imai, A.; Nagase, Y.; Yoshikawa, A.; et al. Advancedglycation endproducts andcognitive impairment in schizophrenia. PLoS ONE2021, 16, e0251283.

12. Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010 Jun;110(6):911-16.e12.
13. José A.B Baptista, Rita C.B Carvalho, Indirect determination of Amadori compounds in milk-based products by HPLC/ELSD/UV as an index of protein deterioration. Food Research International,
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14. Sebeková K, Saavedra G, Zumpe C, Somoza V, Klenovicsová K, Birlouez-Aragon I. Plasma concentration and urinary excretion of N-epsilon-(carboxymethyl)lysine in breast milk- and formula-fed infants. Ann N Y Acad Sci. 2008;1126:177-180.

15. Scheijen JLJM, Clevers E, Engelen L, Dagnelie PC, Brouns F, Stehouwer CDA, Schalkwijk CG. Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database. Food Chem. 2016 Jan 1;190:1145-1150.

16. Harris CS, Beaulieu LP, Fraser MH, McIntyre KL, Owen PL, Martineau LC, Cuerrier A, Johns T, Haddad PS, Bennett SA, Arnason JT. Inhibition of advanced glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity. Planta Med. 2011 Jan;77(2):196-204.

Högt blodsocker påverkar hudens åldrande

1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001:13;414 DOI: 10.1038/414813a

2. Pageon H. Reaction of glycation and human skin: the effects on the skin and its components, reconstructed skin as a model. Pathol Biol. 2010:58;3 DOI: 10.1016/j.patbio.2009.09.009

3. Gkogkolou P. Böhm M. Advanced glycation end products: Key players in skin aging? Dermatoendocrinol. 2012:1;4(3) DOI: 10.4161/derm.22028

4. Cross K., Vetter W.S., Alam Y., et.al. Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses. Biomolecules. 2024:4;14(12) DOI: 10.3390/biom14121550

5. Franceschi C., Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014:69;1 DOI: 10.1093/gerona/glu057

6. Quan T., Qin Z., Xia W., et al. Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc. 2009:14;1 DOI: 10.1038/jidsymp.2009.8

7. Pullar J.M., Carr A.C., Vissers M.C.M. The Roles of Vitamin C in Skin Health. Nutrients. 2017:12;9 DOI: 10.3390/nu9080866

8. Niki E. Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radical Biol Med. 2014:66 DOI: 10.1016/j.freeradbiomed.2013.03.022

9. Colberg S.R., Sigal R.J., Fernhall B., et.al. Exercise and Type 2 Diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care. 2010:33;12 Doi: 10.2337/dc10-9990

10. Zheng W., Li H., Go Y., et.al. Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors. Nutrients. 2022:14;21 DOI: 10.3390/nu14214588

11. Hipkiss A.R., Brownson C., Carrier M.J. Carnosine, a protective, anti-ageing peptide. Mech Ageing Dev. 2001:15;122 DOI: 10.1016/s0047-6374(01)00272-x

12. Uribarri J., Woodruff S., Goodman S., et.al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010:110;6 DOI: 10.1016/j.jada.2010.03.018

13. Aman Y., Schmauck-Medina T., Hansen M., et.al. Autophagy in healthy aging and disease. Nat Aging. 2021:1;8 DOI: 10.1038/s43587-021-00098-4

14. Maloh et.al. The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial. J. Clin. Med. 2023, 12(5), 1710; https://doi.org/10.3390/jcm12051710

Q10 mer än bara hjärthälsa. Kan bidra till metabol balans

Mantle D, Kozhevnikova S, Larsen S. Coenzyme Q10 and Obesity: An Overview. Antioxidants (Basel). 2025 Jul 16;14(7):871.

Nr 2 2025 — Lymfsystemet

Antikens effekt med bevisad effekt mot pollenallergi

Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495-510.

Petit C. Nigella Seeds: Vicks inhaler of Ancient Greece and modern Marrakech. Warwick University, 2014. https://warwick.ac.uk/news/knowledge-archive/arts/nigellaseeds/

He Y, Hu X, Chang L, Liu S, Lv L, Qin G, Jiang L. Meta-analysis of randomized controlled trials assessing the efficacy of nigella sativa supplementation for allergic rhinitis treatment. Front Pharmacol. 2024 Sep 20;15:1417013.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May;3(5):337-52.

Så tar du hand om ditt lymfsystem

1. Moore JE Jr, Bertram CD. Lymphatic System Flows. Annu Rev Fluid Mech. 2018 Jan;50:459-482. doi: 10.1146/annurev-fluid-122316-045259. PMID: 29713107; PMCID: PMC5922450.

2. Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. Lymphatic Vessel Network Structure and Physiology. Compr Physiol. 2018 Dec 13;9(1):207-299. doi: 10.1002/cphy.c180015. PMID: 30549020; PMCID: PMC6459625.

3. Schulze H, Nacke M, Gutenbrunner C, Hadamitzky C. Worldwide assessment of healthcare personnel dealing with lymphoedema. Health Econ Rev. 2018 Apr 16;8(1):10. doi: 10.1186/s13561-018-0194-6. PMID: 29663122; PMCID: PMC5901432.

4. Morfoisse F, Tatin F, Chaput B, Therville N, Vaysse C, Métivier R, Malloizel-Delaunay J, Pujol F, Godet AC, De Toni F, Boudou F, Grenier K, Dubuc D, Lacazette E, Prats AC, Guillermet-Guibert J, Lenfant F, Garmy-Susini B. Lymphatic Vasculature Requires Estrogen Receptor-α Signaling to Protect From Lymphedema. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1346-1357. doi: 10.1161/ATVBAHA.118.310997. Epub 2018 Apr 12. PMID: 29650694.

5. Gashev AA, Zawieja DC. Hydrodynamic regulation of lymphatic transport and the impact of aging. Pathophysiology. 2010 Sep;17(4):277-87. doi: 10.1016/j.pathophys.2009.09.002. Epub 2010 Mar 11. PMID: 20226639; PMCID: PMC5507682.

6. Keast, D., & Towers, A. (2017). The rising prevalence of lymphedema in Canada: A continuing dialogue. Lymphedema Pathways, Spring, 5–8.

7. Hespe GE, Kataru RP, Savetsky IL, García Nores GD, Torrisi JS, Nitti MD, Gardenier JC, Zhou J, Yu JZ, Jones LW, Mehrara BJ. Exercise training improves obesity-related lymphatic dysfunction. J Physiol. 2016 Aug 1;594(15):4267-82. doi: 10.1113/JP271757. Epub 2016 Apr 9. PMID: 26931178; PMCID: PMC4967732.

8. Admoun C, Mayrovitz HN. Coping Mechanisms for Lymphedema: An Analysis of Patient Experiences. Cureus. 2023 Jul 8;15(7):e41573. doi: 10.7759/cureus.41573. PMID: 37554614; PMCID: PMC10406395.

9. Svenska Ödemförbundet https://www.youtube.com/watch?v=Op2wrBQ63OM

10.Stewart JM, Karman C, Montgomery LD, McLeod KJ. Plantar vibration improves leg fluid flow in perimenopausal women. Am J Physiol Regul Integr Comp Physiol. 2005 Mar;288(3):R623-9. doi: 10.1152/ajpregu.00513.2004. Epub 2004 Oct 7. PMID: 15472009.

11.Schneider R. Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: A two-armed, randomized, controlled pragmatic trial. Physiother Theory Pract. 2020 Jan;36(1):63-70. doi: 10.1080/09593985.2018.1479474. Epub 2018 May 30. PMID: 29847188.

12.Keith L, Rowsemitt C, Richards LG. Lifestyle Modification Group for Lymphedema and Obesity Results in Significant Health Outcomes. Am J Lifestyle Med. 2017 Nov 21;14(4):420-428. doi: 10.1177/1559827617742108. PMID: 33281522; PMCID: PMC7692018.

13.Unno N, Tanaka H, Suzuki M, Yamamoto N, Mano Y, Sano M, Saito T, Konno H. Influence of age and gender on human lymphatic pumping pressure in the leg. Lymphology. 2011 Sep;44(3):113-20. PMID: 22165581.

Hjärnans eget lymfsystem skyddar mot hjärndimma och sjukdom

1. Hablitz LM, Nedergaard M. The Glymphatic System: A Novel Component of Fundamental Neurobiology. J Neurosci. 2021 Sep 15;41(37):7698-7711. doi: 10.1523/JNEUROSCI.0619-21.2021. PMID: 34526407; PMCID: PMC8603752.

2. Nilsson, O. (2019, 4 september). Strategiska miljoner till forskning om hjärnflöden. Umeå universitet. https://www.umu.se/nyheter/strategiska-miljoner-till-forskning-om-hjarnfloden_8312661/

3. Lopes DM, Llewellyn SK, Harrison IF. Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system. Transl Neurodegener. 2022 Mar 21;11(1):19. doi: 10.1186/s40035-022-00293-2. PMID: 35314000; PMCID: PMC8935752.

4. Licastro E, Pignataro G, Iliff JJ, Xiang Y, Lo EH, Hayakawa K, Esposito E. Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system. Commun Biol. 2024 Feb 24;7(1):229. doi: 10.1038/s42003-024-05911-5. PMID: 38402351; PMCID: PMC10894274.

5. Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M. Circadian control of brain glymphatic and lymphatic fluid flow. Nat Commun. 2020 Sep 2;11(1):4411. doi: 10.1038/s41467-020-18115-2. PMID: 32879313; PMCID: PMC7468152.

6. Corell, A., Jakola, A. S., & Skoglund, T. (2023, februari 8). Glymfatiska systemet – renar hjärnan från slaggprodukter: Störningar i systemet skulle kunna vara orsak till sjukdomar. Läkartidningen. https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2023/02/glymfatiska-systemet-renar-hjarnan-fran-slaggprodukter/

7. Reddy OC, van der Werf YD. The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci. 2020 Nov 17;10(11):868. doi: 10.3390/brainsci10110868. PMID: 33212927; PMCID: PMC7698404.

8. Sugama S, Kakinuma Y. Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response. Neurochem Int. 2021 Feb;143:104943. doi: 10.1016/j.neuint.2020.104943. Epub 2020 Dec 16. PMID: 33340593.

9. Sriram S, Carstens K, Dewing W, Fiacco TA. Astrocyte regulation of extracellular space parameters across the sleep-wake cycle. Front Cell Neurosci. 2024 Jun 26;18:1401698. doi: 10.3389/fncel.2024.1401698. PMID: 38988660; PMCID: PMC11233815.

10.Bao C, Luo H, Wang J, Liu X, Li Y, Yang J, Chen C, Yang R, Ba W, Lian X, Dunk M, Liu J, Xu W. Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer’s disease: A DTI-ALPS study. J Prev Alzheimers Dis. 2025 Apr 11:100156. doi: 10.1016/j.tjpad.2025.100156. Epub ahead of print. PMID: 40221240.

11.Zhao X, Cao R, Tian X, Liu P, Liu D, Yu X, Zheng Z, Chen GL, Zou L. OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson’s Disease Model Mice Induced by Rotenone. Neurochem Res. 2025 Apr 12;50(2):142. doi: 10.1007/s11064-025-04388-w. PMID: 40220255.

12.Gong W, Zhai Q, Wang Y, Shen A, Huang Y, Shi K, Huang Y, Song M, Yan R, Yao Z, Lu Q. Glymphatic function and choroid plexus volume is associated with systemic inflammation and oxidative stress in major depressive disorder. Brain Behav Immun. 2025 Apr 11;128:266-275. doi: 10.1016/j.bbi.2025.04.008. Epub ahead of print. PMID: 40220922.

13.Chaganti JR, Talekar TK, Brew BJ. Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption. BMC Neurol. 2025 Mar 19;25(1):112. doi: 10.1186/s12883-025-04133-4. PMID: 40108491; PMCID: PMC11921593.

14.Wu L, Zhang Z, Liang X, Wang Y, Cao Y, Li M, Zhou F. Glymphatic system dysfunction in recovered patients with mild COVID-19: A DTI-ALPS study. iScience. 2023 Dec 7;27(1):108647. doi: 10.1016/j.isci.2023.108647. PMID: 38155770; PMCID: PMC10753064.

15.Che Mohd Nassir CMN, Che Ramli MD, Mohamad Ghazali M, Jaffer U, Abdul Hamid H, Mehat MZ, Hein ZM. The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Life (Basel). 2024 Dec 24;15(1):3. doi: 10.3390/life15010003. PMID: 39859943; PMCID: PMC11766513.

16.Johansson, B., Andréll, P., Mannheimer, C., & Rönnbäck, L. (2022). Hjärntrötthet – ett osynligt gissel: Möjliga förklaringar, diagnostik och möjliga behandlingar. Läkartidningen, 119, 21073. https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/vetenskapsradet/2022/03/hjarntrotthet–ett-osynligt-gissel/

17.Olegário RL, Nóbrega OT, Camargos EF. The newly discovered glymphatic system: the missing link between physical exercise and brain health? Front Integr Neurosci. 2024 Apr 16;18:1349563. doi: 10.3389/fnint.2024.1349563. PMID: 38690084; PMCID: PMC11058641.

18.Liu X, Hao J, Yao E, Cao J, Zheng X, Yao D, Zhang C, Li J, Pan D, Luo X, Wang M, Wang W. Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems. Brain Behav Immun. 2020 Oct;89:357-370. doi: 10.1016/j.bbi.2020.07.022. Epub 2020 Jul 24. PMID: 32717402.

19.Cheng Y, Liu X, Ma X, Garcia R, Belfield K, Haorah J. Alcohol promotes waste clearance in the CNS via brain vascular reactivity. Free Radic Biol Med. 2019 Nov 1;143:115-126. doi: 10.1016/j.freeradbiomed.2019.07.029. Epub 2019 Jul 27. PMID: 31362045.

20.Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Sci Rep. 2018 Feb 2;8(1):2246. doi: 10.1038/s41598-018-20424-y. PMID: 29396480; PMCID: PMC5797082.

Kost och näringsämnen som stöttar lymfsystemet

Clark O. Lymphatic system. Publifye AS. 2025

2. Mora J.R., Iwata M., von Andrian U.H. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008:8;9. DOI: 10.1038/nri2378

3. van Gorkom G.N.Y., Klien Wolterink R.G.J., van Elssen C.H.M.J., et.al. Influence of Vitamin C on Lymphocytes: An Overview. Antioxidants 2018:7;3. DOI: https://doi.org/10.3390/antiox7030041

4. Honscheid A., Rink L., Haase H. T-Lymphocytes: A Target for Stimulatory and Inhibitory Effects of Zinc Ions. Endocrine, Metabolic & Immune Disorders-Drug Targets. 2009:9;2 DOI: https://doi.org/10.2174/187153009788452390

5. Treven P. Mrak V., Bogovic Matijasic B. et.al. Administration of probiotics Lactobacillus rhamnosus GG and Lactobacillus gasseri K7 during pregnancy and lactation changes mouse mesenteric lymph nodes and mammary gland microbiota. Journal of Dairy Science. 2015:98;4 DOI: https://doi.org/10.3168/jds.2014-8519

6. Teuwen L-A, Geldhof V., Carmeliet P. How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development. Develpmental Biology. 2019:447;1. DOI: https://doi.org/10.1016/j.ydbio.2017.12.001

7. Satoh Y., Kotani H., Iida Y., et.al. Supplementation of l-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy. The official journal of the Japanese Cancer Association. 2020:111;7 DOI: https://doi.org/10.1111/cas.14490

Perrintekniken när lymfsystemet har “kloggat igen”

1. Heald A, Perrin R, Walther A, Stedman M, Hann M, Mukherjee A, Riste L. Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention. Cardiovasc Endocrinol Metab. 2022 Apr 12;11(2):e0261.

2. Hives L, Bradley A, Richards J, Sutton C, Selfe J, Basu B, Maguire K, Sumner G, Gaber T, Mukherjee A, Perrin RN. Can physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study. BMJ Open. 2017 Nov 13;7(11):e017521.

Lymfmassage i ansiktet

https://pmc.ncbi.nlm.nih.gov/articles/PMC10045879/

https://www.cedars-sinai.org/blog/lymphatic-drainage-massage-faqs.html

https://www.self.com/story/facial-lymphatic-drainage-massage

Bara bra att bada bastu?

1.Salonen JT, Seppänen K, Rauramaa R, Salonen R. Risk factors for carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Med. 1989 Jun;21(3):227-9.

2.Engström Å, Hägglund H, Lee E, Wennberg M, Söderberg S, Andersson M. Sauna bathing in northern Sweden: results from the MONICA study 2022. Int J Circumpolar Health. 2024 Dec;83(1):2419698.

Q10 och selen förbättrar ämnesomsättningen hos äldre

Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium – positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024 May 7;22(1):191.

Krönika: Tillsatserna gör oss sjuka

https://clinicaltrials.gov/study/NCT03335644

Sellem L, Srour B, Javaux G, Chazelas E, Chassaing B, Viennois E, Debras C, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Arnault N, Agaësse C, De Sa A, Lutchia R, Huybrechts I, Scalbert A, Pierre F, Coumoul X, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Santé cohort. PLoS Med. 2024 Feb 13;21(2):e1004338.

Kavanaugh M, Rodgers D, Rodriguez N, Leroy F. Considering the nutritional benefits and health implications of red meat in the era of meatless initiatives. Front Nutr. 2025 Jan 27;12:1525011.

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1525011/full

You W, Henneberg R, Saniotis A, Ge Y, Henneberg M. Total Meat Intake is Associated with Life Expectancy: A Cross-Sectional Data Analysis of 175 Contemporary Populations. Int J Gen Med. 2022 Feb 22;15:1833-1851.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8881926/

Nr 1 2025 — Värk

Magnesium kan vara effektivt vid smärta

1.Morel V., Pickering M-E., Goubayon J. et.al. Magnesium for Pain Treatment in 2021? State of the Art. Nutritents. 2021:13;5 Magnesium for Pain Treatment in 2021? State of the Art

2.Dolati S., Rikhtegar R., Mehdizadeh A., Yousefi M. The Role of Magnesium in Pathophysiology and Migraine Treatment. Biological Trace Element Research. 2020:196 DOI: 10.1007/s12011-019-01931-z

3.Alshammari E. Magnesium supplementation for premenstrual syndrome and premenstrual dysphoric disorder. International Journal of Pharmaceutical Research. 2021:13;1 DOI:10.31838/ijpr/2021.13.01.095

4.Yaralizadeh M., Nezamivand-Chegini S., Najar S., et.al. Effectiveness of Magnesium on Menstrual Symptoms Among Dysmenorrheal College Students: A Randomized Controlled Trial. 2024:12;2 pdf_IJWHR_624.pdf

5.Boulis M., Boulis M., Clauw D. Magnesium and Fibromyalgia: A Literature Review. Journal of Primary Care & Community Health. 2021. https://doi.org/10.1177/21501327211038433

6.El Sayed Z.M., Abouzeid, A.E.,El Sood A.I.A. Evaluating Effectiveness of Intravenous Magnesium Sulfate as a Treatment in Acute Renal Colic Patients Attending Suez Canal University Hospital Emergency Department. Medical Journal of Cairo University. 2019:87. DOI: 10.21608/mjcu.2019.70360

7.Jokar, A., Cyrus, A.,Babaei, M., et.al. The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial. Emergency. Tehran. 2017:5. The Effect of Magnesium Sulfate on Renal Colic Pain Relief; a Randomized Clinical Trial – PMC

8.Zolfaghari Sadrabad A., Azimi Abarghouei S., Farahmand Rad R. Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial. The American Journal of Emergency Medicine. 2021:46. DOI: https://doi.org/10.1016/j.ajem.2020.07.035

Lipödem – en missförstådd smärtsjukdom

1.Falck J, Rolander B, Nygårdh A, Jonasson LL, Mårtensson J. Women with lipoedema: a national survey on their health, health-related quality of life, and sense of coherence. BMC Womens Health. 2022 Nov 18;22(1):457.

2.Poojari A, Dev K, Rabiee A. Lipedema: Insights into Morphology, Pathophysiology, and Challenges. Biomedicines. 2022 Nov 30;10(12):3081.

3.Aksoy H, Karadag AS, Wollina U. Cause and management of lipedema-associated pain. Dermatol Ther. 2021 Jan;34(1):e14364.

4.SVT. https://www.svt.se/nyheter/inrikes/hard-kritik-mot-lipodem-varden-ett-brott-mot-halso-och-sjukvardslagen

5.Cannataro R, Michelini S, Ricolfi L, Caroleo MC, Gallelli L, De Sarro G, Onorato A, Cione E. Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up. Life (Basel). 2021 Dec 15;11(12):1402.

6.Katzer K, Hill JL, McIver KB, Foster MT. Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation. Int J Mol Sci. 2021 Oct 29;22(21):11720.

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13.Herrera, M., Molina, P., & Souza-Smith, F.M. Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation. American Journal of Physiology – Cell Physiology. 2021;321:C104-C116.

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20.Keith L, Seo CA, Rowsemitt C, Pfeffer M, Wahi M, Staggs M, Dudek J, Gower B, Carmody M. Ketogenic diet as a potential intervention for lipedema. Med Hypotheses. 2021 Jan;146:110435. doi: 10.1016/j.mehy.2020.110435. Epub 2020 Nov 27. PMID: 33303304.

21.Verde L, Camajani E, Annunziata G, Sojat A, Marina LV, Colao A, Caprio M, Muscogiuri G, Barrea L. Ketogenic Diet: A Nutritional Therapeutic Tool for Lipedema? Curr Obes Rep. 2023 Dec;12(4):529-543. doi: 10.1007/s13679-023-00536-x. Epub 2023 Nov 4. PMID: 37924422; PMCID: PMC10748777.

22.Jeziorek M, Chachaj A, Sowicz M, Adaszyńska A, Truszyński A, Putek J, Kujawa K, Szuba A. The Benefits of Low-Carbohydrate, High-Fat (LCHF) Diet on Body Composition, Leg Volume, and Pain in Women with Lipedema. J Obes. 2023 Nov 18;2023:5826630. doi: 10.1155/2023/5826630. PMID: 38026822; PMCID: PMC10676278.

23.Donahue PMC, Crescenzi R, Petersen KJ, Garza M, Patel N, Lee C, Chen SC, Donahue MJ. Physical Therapy in Women with Early Stage Lipedema: Potential Impact of Multimodal Manual Therapy, Compression, Exercise, and Education Interventions. Lymphat Res Biol. 2022 Aug;20(4):382-390. doi: 10.1089/lrb.2021.0039. Epub 2021 Nov 8. PMID: 34748408; PMCID: PMC9422785.

24.SGU https://www.sgu.se/anvandarstod-for-geologiska-fragor/bedomningsgrunder-for-grundvatten/grundvattnets-kvalitet–oorganiska-amnen/selen/

Hur stress och trauma påverkar kronisk värk

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7.Försäkringskassan. Rekordmånga sjukskrivs för stress. https://www.forsakringskassan.se/nyhetsarkiv/nyheter-press/2024-11-18-rekordmanga-sjukskrivs-for-stress

8.FN, https://www.iwsthlm.se/wp-content/uploads/2016/02/BVB_2016-UNDP.pdf.

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10.Lumley MA, Cohen JL, Borszcz GS, Cano A, Radcliffe AM, Porter LS, Schubiner H, Keefe FJ. Pain and emotion: a biopsychosocial review of recent research. J Clin Psychol. 2011 Sep;67(9):942-68. doi: 10.1002/jclp.20816. Epub 2011 Jun 6. PMID: 21647882; PMCID: PMC3152687.

11.https://www.forskning.se/2025/02/04/endometrios-smarta-forskning/

12.Rivi, V., Rigillo, G., Toscano, Y., Benatti, C., & Blom, J. M. C. (2023). Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes. Children, 10(7), 1217.

13.Stumbo, S. P., Yarborough, B. J., McCarty, D., Weisner, C., & Green, C. A. (2017). Patient-reported pathways to opioid use disorders and pain-related barriers to treatment engagement. Journal of Substance Abuse Treatment, 73, 47-54.

14.Mischkowski, D., Crocker, J., & Way, B. M. (2019). A Social Analgesic? Acetaminophen (Paracetamol) Reduces Positive Empathy. Frontiers in Psychology, 10, 538.

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18.Vetenskap och hälsa. (n.d.). När stressen sätter sig i käkarna.

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20.Vinstrup, J., Jakobsen, M. D., & Andersen, L. L. (2020). Perceived Stress and Low-Back Pain Among Healthcare Workers: A Multi-Center Prospective Cohort Study. Frontiers in Public Health, 8, 297.

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22.Kennedy, C., Kassab, O., Gilkey, D., Linnel, S., & Morris, D. (2008). Psychosocial factors and low back pain among college students. Journal of American College Health, 57(2), 191-195.

23.Takegami, N., Akeda, K., Yamada, J., Nishimura, A., & Sudo, A. (2024). Association between low back pain and psychological stress response in a Japanese population-based study. Journal of Orthopaedic Science, 29(3), 749-754.

24.Power, C., Frank, J., Hertzman, C., Schierhout, G., & Li, L. (2001). Predictors of low back pain onset in a prospective British study. American Journal of Public Health, 91, 1671-8.

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Matpyramid mot kronisk smärta

1.Rondanelli M, Faliva MA, Miccono A, Naso M, Nichetti M, Riva A, Guerriero F, De Gregori M, Peroni G, Perna S. Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents. Nutr Res Rev. 2018 Jun;31(1):131-151.

2.Schols, J.M.G.A., De Groot, C.P.G.M., Van der Cammen, T.J.M. and Olde Rikkert, M.G.M. (2008) Preventing and treating dehydration in the elderly during periods of illness and warm weather. The Journal of Nutrition Health and Aging. 13 (2), 150–57.

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5.Guagnano MT, D’Angelo C, Caniglia D, Di Giovanni P, Celletti E, Sabatini E, Speranza L, Bucci M, Cipollone F, Paganelli R. Improvement of Inflammation and Pain after Three Months’ Exclusion Diet in Rheumatoid Arthritis Patients. Nutrients. 2021 Oct 9;13(10):3535.

Mindre kolhydrater, mindre smärta

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Framtidens smärtbehandling

1.Deer TR, Grider JS, Lamer TJ, Pope JE, Falowski S, Hunter CW, Provenzano DA, Slavin KV, Russo M, Carayannopoulos A, Shah JM, Harned ME, Hagedorn JM, Bolash RB, Arle JE, Kapural L, Amirdelfan K, Jain S, Liem L, Carlson JD, Malinowski MN, Bendel M, Yang A, Aiyer R, Valimahomed A, Antony A, Craig J, Fishman MA, Al-Kaisy AA, Christelis N, Rosenquist RW, Levy RM, Mekhail N. A Systematic Literature Review of Spine Neurostimulation Therapies for the Treatment of Pain. Pain Med. 2020 Nov 7;21(7):1421-1432. doi: 10.1093/pm/pnz353. Erratum in: Pain Med. 2021 Feb 4;22(1):236. doi: 10.1093/pm/pnaa209. PMID: 32034422.

2.Strand N, J M, Tieppo Francio V, M M, Turkiewicz M, El Helou A, M M, S C, N S, J P, C W. Advances in Pain Medicine: a Review of New Technologies. Curr Pain Headache Rep. 2022 Aug;26(8):605-616. doi: 10.1007/s11916-022-01062-6. Epub 2022 Jul 29. PMID: 35904729; PMCID: PMC9334973.

3. https://www.akademiska.se/for-vardgivare/sektioner/smartcentrum/ryggmargsstimulering/

4. https://www.lu.se/artikel/smartlindring-utan-biverkningar-med-sjograsmjuk-teknik

5.Forni M, Thorbergsson PT, Thelin J, Schouenborg J. 3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects. Sci Adv. 2021 Oct 8;7(41):eabj2847. doi: 10.1126/sciadv.abj2847. Epub 2021 Oct 8. PMID: 34623922; PMCID: PMC8500508.

6.Holmkvist, A.D., Agorelius, J., Forni, M. et al. Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice. J Nanobiotechnol 18, 27 (2020). https://doi.org/10.1186/s12951-020-0585-9

7. https://www.lu.se/artikel/nanopartiklar-kommer-lastade-med-lakemedel-till-hjarnan

8. Slitzky M, Yong RJ, Lo Bianco G, Emerick T, Schatman ME, Robinson CL. The Future of Pain Medicine: Emerging Technologies, Treatments, and Education. J Pain Res. 2024 Aug 30;17:2833-2836. doi: 10.2147/JPR.S490581. PMID: 39228514; PMCID: PMC11370752.

9. Logan DE, Simons LE, Caruso TJ, Gold JI, Greenleaf W, Griffin A, King CD, Menendez M, Olbrecht VA, Rodriguez S, Silvia M, Stinson JN, Wang E, Williams SE, Wilson L. Leveraging Virtual Reality and Augmented Reality to Combat Chronic Pain in Youth: Position Paper From the Interdisciplinary Network on Virtual and Augmented Technologies for Pain Management. J Med Internet Res. 2021 Apr 26;23(4):e25916. doi: 10.2196/25916. PMID: 33667177; PMCID: PMC8111507.

10. Li A, Montaño Z, Chen VJ, Gold JI. Virtual reality and pain management: current trends and future directions. Pain Manag. 2011 Mar;1(2):147-157. doi: 10.2217/pmt.10.15. PMID: 21779307; PMCID: PMC3138477.

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12. Henderson I, Elsaadany R, Chan G, Bajaj V, Duarte D, Goodman S, Grunstein M, Vadhan NP, Duarte RA. Exploring the Potential of Psychedelics in the Treatment of Headache Disorders: Clinical Considerations and Exploratory Insights. Curr Pain Headache Rep. 2025 Jan 16;29(1):28. doi: 10.1007/s11916-024-01321-8. PMID: 39820774

13. Lin C, Wang X, Wang X. Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine. Neurosci Bull. 2025 Jan 20. doi: 10.1007/s12264-025-01351-1. Epub ahead of print. PMID: 39832122.

14. Barber G, Nemeroff CB, Siegel S. A Case of Prolonged Mania, Psychosis, and Severe Depression After Psilocybin Use: Implications of Increased Psychedelic Drug Availability. The American Journal of Psychiatry. 2022 Dec;179(12):892-896. DOI: 10.1176/appi.ajp.22010073. PMID: 36453037.

15. Bremler, R., Katati, N., Shergill, P. et al. Case analysis of long-term negative psychological responses to psychedelics. Sci Rep 13, 15998 (2023). https://doi.org/10.1038/s41598-023-41145-x

16. Bonnelle V, Smith WJ, Mason NL, Cavarra M, Kryskow P, Kuypers KP, Ramaekers JG, Feilding A. Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey. Br J Pain. 2022 Dec;16(6):619-631. doi: 10.1177/20494637221114962. Epub 2022 Jul 14. PMID: 36452124; PMCID: PMC9703241.

En ny behandling av magsårsbakterien

1.Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D m.fl. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017;153(2):420-9.

2.Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infectious Diseases. 2018;18(3):318-27.

3.Holz C, Busjahn A, Mehling H, Arya S, Boettner M, Habibi H, et al. Significant Reduction in Helicobacter pylori Load in Humans with Non-viable Lactobacillus reuteri DSM17648: A Pilot Study. Probiotics and Antimicrobial Proteins. 2015;7(2):91-100.

4.Mehling H, Busjahn A. Non-Viable Lactobacillus reuteri DSMZ 17648 (Pylopass (TM)) as a New Approach to Helicobacter pylori Control in Humans. Nutrients. 2013;5(8):3062-73

5.Buckley M, Lacey S, Doolan A, Goodbody E, Seamans K. The effect of Lactobacillus reuteri supplementation in Helicobacter pylori infection: a placebo-controlled, single-blind study. Bmc

6.2018;4(1):1-8.

7.Muresan IAP, Pop LL, Dumitrascu DL. Lactobacillus reuteri versus triple therapy for the eradication of Helicobacter pylori in functional dyspepsia. Med Pharm Rep. 2019;92(4):352-5.

8.Parolova NI, Kornienko EA, Antonov PV, Egorova MB, Gorbunov EF, Dmitrienko MA. An innovative approach in the treatment of H. pylori infection in children. Russian Medical Journal2015.

9.Kornienko EA, Parolova NI, Ivanov SV, Polev DS, Zykin PA, Kondratenko YD, et al. Gastric microbiota and probiotics opportunities in helicobacter pylori eradication in children. Gastroenterology & Hepatology: Open Access. 2020;11(1):13-23.

A-vitamin och betakaroten för hudens hälsa

1.Offord E.A, Gautier J.C., Avanti O., et al. Photoprotective potential of lycopene, beta-carotene, E-vitamin, C- and A-vitamin and carnosic acid in UVA-irradiated human skin fibroblasts. Free radical biology and medicine. 2002:32;12 DOI: https://doi.org/10.1016/S0891-5849(02)00831-6

2.Kurokawa I et.al. New developments in our understanding of acne pathogenesis and treatment. Experimental Dermatology. 2009;18 DOI: 10.1111/j.1600-0625.2009.00890.x

3.Nagata C, Nakamura K, Wada K et.al. Association of dietary fat, vegetables and antioxidant micronutrients with skin ageing in Japanese women. British Medical Journal. 2010;103 DOI:10.1017/S0007114509993461

4.Leung W.C., Hessel S, Méplan C., et.al. Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers. FASEB Journal. 2008:23;4 DOI: https://doi.org/10.1096/fj.08-121962

Fosfolipider: Cellmembranens livsviktiga byggstenar

1.Nylander M (1994) Antioxidanter – Skyddet mot fria radikaler. Faktaskrift som utgivits av Hälsokostrådet. Förlag: Hälsokostrådets Förlag. Tryckeri: TryckeriEtt 1993. ISBN: 91 86170 57-0

2.Nylander M (1994) FREE RADICALS – ANTIOXIDANTS. In: Heavy Metal Bulletin, Volyme 1 -Issue 2, October 1994 (bil.VI:4D).Tysk version: Freie Radikale – antioxidanten. Schwermetall Bulletin.

3.Nylander M & Carlmark B (2009) Vad är oxidativ stress. Näringsmedicinsk tidskrift 3:9-10, 21-22.

4.Nylander M (2011) Oxidativ stress. STARK 3:35-38.

5.Nylander M (2014) Oxidativ stress är vanligast bland medelålders kvinnor. Medicinsk Access 3:6-11.

6.Nicolson G L et al (2024) Membrane Lipid Replacement and its Role in Restoring Mitochondrial Membrane Function and Reducing Symptoms in Aging and Age-related Clinical Conditions. Nature Cell and Science 2(4):238-256.

7.Singer SJ & Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science; 175 (4023):720-31.

8.Agadjanyan M et al (2003) Nutrtional supplement (NTFactor®) restores mitochondrial function and reduce moderately severe fatigue in aged subjects. J. Chronic. Fatigue Syndr; 11(3):23-36.

9.Nicolson GL et al (2017) Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phodpholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta Biomembr; 1859(9):1704-1724.

10.Ellithorpe RA et al (2015) Blood homocysteine and fasting insulin levels are reduced and erythrocyte sedimentation rates are increased with a glycophospholipid vitamin formulation: a retrospective study in older subjects. Funct. Foods Health Dis; 5(4):126-135.

Nr 4 2024 – Hjärta & Kärl

Rätt kost förebygger åderförkalkning

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12?

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Kost, kolesterol & hjärt-kärlsjukdom

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OxLDL En orsak till att plack bildas I kärlen

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Ubiquinol Q10 kan skydda hjärta och kärl

[1]. WHO: The top 10 causes of death. Hämtad 2024-01-25 The top 10 causes of death (who.int)

2. Hjärt-lungfonden. Hämtad 2024-01-25 Livsviktig forskning pågår | Hjärt-Lungfonden (hjart-lungfonden.se)

3.Socialstyrelsen. Statistik om läkemedel 2022. Hämtad 2024-01-25 Statistik om läkemedel – Socialstyrelsen

4. Jenny Loftrup. Så tar du hand om ditt hjärta. Vetenskap och Hälsa, maj 2023. Så tar du hand om ditt hjärta – Vetenskap och Hälsa (vetenskaphalsa.se)
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8. Banach M et al. Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group. Statin therapy and plasma coenzyme Q10 concentrations–A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015 Sep;99:329-36. Statin therapy and plasma coenzyme Q10 concentrations–A systematic review and meta-analysis of placebo-controlled trials – PubMed (nih.gov)

9.Kalén A et al. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989 Jul;24(7):579-84. Age-related changes in the lipid compositions of rat and human tissues – PubMed (nih.gov)

10. Alehagen U et al. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens. PLoS ONE 2015, 10, e0141641. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens – PMC (nih.gov)
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12. Sabbatinelli J et al. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial. Nutrients. 2020 Apr 15;12(4):1098. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial – PubMed (nih.gov)

13, Thijssen DHJ et al. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur. Heart J. 2019, 40, 2534–2547. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans – PubMed (nih.gov)

14.Mortensen SA et al. Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results from Q-SYMBIO: A randomized double-blind trial. JACC Heart Fail. 2014, 2, 641–649. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial – PubMed (nih.gov)

1 Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors. 2008;32(1-4):119-28. Supplemental ubiquinol in patients with advanced congestive heart failure – PubMed (nih.gov)

16.Hosoe K et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers – PubMed (nih.gov)

17.Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial – PubMed (nih.gov)

18.Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men – PubMed (nih.gov)

19.García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency – PubMed (nih.gov)

ApoB och Lp(a)

1.Vinci P, Di Girolamo FG, Panizon E, Tosoni LM, Cerrato C, Pellicori F, Altamura N, Pirulli A, Zaccari M, Biasinutto C, Roni C, Fiotti N, Schincariol P, Mangogna A, Biolo G. Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives. Int J Environ Res Public Health. 2023 Sep 6;20(18):6721.

2.Lippi G, Guidi G. Lipoprotein(a): from ancestral benefit to modern pathogen? QJM. 2000 Feb;93(2):75-84.

3.Kostakou PM, Hatzigeorgiou G, Kolovou V, Mavrogeni S, Kolovou GD. Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels. Curr Med Chem. 2017;24(10):969-978.

4.Koutsogianni AD, Liamis G, Liberopoulos E, Adamidis PS, Florentin M. Effects of Lipid-Modifying and Other Drugs on Lipoprotein(a) Levels-Potent Clinical Implications. Pharmaceuticals (Basel). 2023 May 16;16(5):750.

5.Tsimikas S. A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies. J Am Coll Cardiol. 2017 Feb 14;69(6):692-711.

6.Serban MC, Sahebkar A, Mikhailidis DP, Toth PP, Jones SR, Muntner P, Blaha MJ, Andrica F, Martin SS, Borza C, Lip GY, Ray KK, Rysz J, Hazen SL, Banach M. Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2016 Jan 12;6:19188.

7.Sahebkar A, Simental-Mendía LE, Stefanutti C, Pirro M. Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis. Pharmacol Res. 2016 Mar;105:198-209.

8.Kosmas CE, Bousvarou MD, Papakonstantinou EJ, Tsamoulis D, Koulopoulos A, Echavarria Uceta R, Guzman E, Rallidis LS. Novel Pharmacological Therapies for the Management of Hyperlipoproteinemia(a). Int J Mol Sci. 2023 Sep 3;24(17):13622.

9.Suk Danik J, Rifai N, Buring JE, Ridker PM. Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events. J Am Coll Cardiol. 2008 Jul 8;52(2):124-31.

10.Vinci P, Di Girolamo FG, Panizon E, Tosoni LM, Cerrato C, Pellicori F, Altamura N, Pirulli A, Zaccari M, Biasinutto C, Roni C, Fiotti N, Schincariol P, Mangogna A, Biolo G. Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives. Int J Environ Res Public Health. 2023 Sep 6;20(18):6721.

11.Di Fusco SA, Maggioni AP, Scicchitano P, Zuin M, D’Elia E, Colivicchi F. Lipoprotein (a), Inflammation, and Atherosclerosis. J Clin Med. 2023 Mar 27;12(7):2529

Nattokinas: Ett naturligt skydd mot åderförkalkning

Nattokinas: Ett naturligt skydd mot åderförkalkning

Nagata C et al. Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study. Am J Clin Nutr. (2017) 105:426-31.
Sumo H et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto; a typical and popular soybean f in the Japanese diet. Experentia. (1987) 43: 1110-1.

Suzuki Y et al. Dietary supplementation with fermented soybeans supresses intimal thickening. Nutrition. (2003) 19: 261-4.
Suzuki Y et al. Dietary supplementation with fermented soybean, natto, suppresses intimal thickening and modulate the lysis of mural trombi after endothelial injury in rat femoral artery. Life Sci (2003) 73: 1289-98.
Kang SJ et al. Korean red ginseng combined with nattokinase amelioriates dyslipidemia and the area of aortic plaquesin high cholesterol-diet fed rabbits. Food Sci Biotechnol. (2014) 23: 283-7.
Xie S et al. Preparation of nattokinase and study on its hypolipidemic effect. Chin J Biochem Pharm. Food Sci. (2015) 35: 17-20.
Meng F et al. Effects of nattokinase on blood lipid and rheology in atherosclerosis model rat. Chin J Lab Diagn. (2013) 17:1567-9.
Duan Z et al. Study on the antioxidative activity and effects on experimental hyperlipidemia of natto extract. Acta Nutrimenta Sin. (2004) 26: 296-9.
Park KJ et al. The antithrombotic and fibrinolytic effect of natto in hypercholesterolemia rats. Prev. Nutr. Food Sci. (2012) 17: 78-82.
Iwai K et al. Antioxidative functions of natto, a kind of fermented soybeans: effect on LDL oxidation and lipid metabolism in cholesterol-fed rats. J Agric Food Chem. (2002) 50: 3597-601.
Hodis HN et al. Nattokinase atherothrombotic prevention study: A randomized trial. Clin Hemorheol Microcirc. (2021) 78: 339-53.
Ren N et al. A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia. Nat Med J China. (2017) 97: 2038-42.
Chen H et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Front Cardiovasc Med (2022) 9: 964977.
Chen H et al. Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases. Biomark Insights. (2018) 13:1177.
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C-vitaminbrist – en riskfaktor för hjärt-kärlsjukdom

1.Morelli M.B., Gambardella J., Castellanos V., et.al. Vitamin C and Cardiovascular Disease: An Update. Antioxidants (Basel). 2020:9;12

2.May J.M., Harrison F.E. Role of Vitamin C in the function of the vascular endothelium. Antioxid Redox Signal. 2013:19(17)

3.Kugiyama K., Motoyama T., Hirashima O., et. al. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol. 1998:32

4.Jeserich M, Schindler T, Olschewski M, et.al. Vitamin C improves endothelial function of epicardial coronary arteries in patients with hypercholesterolaemia or essential hypertension-assessed by cold pressor testing. Eur Heart J. 1999:20;22

5.Schindler T.H., Magosaki N., Jeserich M., et.al. Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing. Cardiology. 2001;94;4

6.Tousoulis D., Xenakis C., Tentolouris C., et.al. Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart. 2005;91;10

7.Solzbach U., Hornig B., Jeserich M., Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation. 1997;96;5

8.Brabson JP, Leesang T, Mohammad S, Cimmino L. Epigenetic regulation of genomic stability by vitamin C. Front Genet. 2021;12:675780. https://doi.org/10.3389/fgene.2021.675780.

9.Hemilä H. de Man A.M.E. Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports. BMC Pulmonary Medicine. 2024: 24;140

10.Chen L., Sun X., Wang Z., et.al. The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer’s disease: a mendelian randomization study. Clin Nutr. 2021;40;10

11.Lynch S.M., Gaziano J.M., Frei B. Ascorbic acid and atherosclerotic cardiovascular disease. Subcell Biochem. 1996:25 10.1007/978-1-4613-0325-1_17

12.Ruiz-León A.M., Lapuente M., Estruch R., Casas R. Clinical Advances in Immunonutrition and Atherosclerosis: A Review. Nutritional Immunology. 2019:10

13.McRae M.P. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. Journal of Chiropractic Medicine. 2008:7;2

14.Pfister R., Sharp S.J., Luben R., et.al. Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition-Norfolk prospective study. Am Heart J. 2011;162;2

15.Wannamethee S.G., Bruckdorfer K.R., Shaper A.G., et.al. Plasma vitamin C, but not vitamin E, is associated with reduced risk of heart failure in older men. Circ Heart Fail. 2013;6;4

16.Jia J., Zhang J., He Q., et.al. Association between dietary vitamin C and abdominal aortic calcification among the US adults. Nutrition Journal. 2023:22

17.Juraschek S.P., Guallar E., Appel L.J., Miller E.R. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;95;5

18.Ashor A.W., Lara J., Mathers J.C., Siervo M. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2012;235

Så slipper du vintertorr hy

Nagata C, Nakamura K, Wada K et al. Association of dietary fat, vegetables and antioxidant micronutrients with skin ageing in Japanese women. British Medical Journal. 2010;103:
de Spirt S, Stahl W, Tronnier H, Sies H et al. Intervention with flaxseed and borage oil supplements modulates skin condition in women. British Journal of Nutrition. 2009;101
American Academy of Dermatology Association. Heart disease: 12 warning signs that appear on your skin (aad.org)

4. Hirschmann JV and Raugi GJ. “Blue (or purple) toe syndrome.” J Am Acad Dermatol. 2009; 60(1):1-20.

Varierad och fermenterad kost ökar mångfalden i tarmfloran

1.Goda bakterier: Hellre mångfald än enfald, Fredrik Hedlund, först publicerat i tidningen Medicinsk Vetenskap nr 3/2017. Hämtad 2024-11-05 Goda bakterier: Hellre mångfald än enfald | Karolinska Institutet

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14.
Bourdeau-Julien I, Castonguay-Paradis S, Rochefort G, Perron J, Lamarche B, Flamand N, Di Marzo V, Veilleux A, Raymond F. The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population. Microbiome. 2023 Feb 11;11(1):26.
Turnbaugh P.J., Hamady M., Yatsunenko T., Cantarel B.L., Duncan A., Ley R.E. A core gut microbiome in obese and lean twins. Nature. 2009;457:480–484.
Larsen N., Vogensen F.K., van den Berg F.W.J., Nielsen D.S., Andreasen A.S., Pedersen B.K. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 2010;5:e9085.
Ott S.J., Musfeldt M., Wenderoth D.F., Hampe J., Brant O., Fölsch U.R. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut. 2004;53:685–693.
Wilkins LJ, Monga M, Miller AW. Defining Dysbiosis for a Cluster of Chronic Diseases. Sci Rep. 2019 Sep 9;9(1):12918.
Neuman H, Forsythe P, Uzan A, Avni O, Koren O. Antibiotics in early life: dysbiosis and the damage done. FEMS Microbiol Rev. 2018 Jul 1;42(4):489-499.

9.Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016 Mar 5;5(5):317-320.

10.Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Diet-induced extinctions in the gut microbiota compound over generations. Nature. 2016 Jan 14;529(7585):212-5.

Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, Topf M, Gonzalez CG, Van Treuren W, Han S, Robinson JL, Elias JE, Sonnenburg ED, Gardner CD, Sonnenburg JL. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021 Aug 5;184(16):4137-4153.
Rezac S, Kok CR, Heermann M, Hutkins R. 2018. Fermented foods as a dietary source of live organisms. Front Microbiol 9:1785.
Marco ML, Heeney D, Binda S, Cifelli CJ, Cotter PD, Foligné B, Gänzle M, Kort R, Pasin G, Pihlanto A, Smid EJ, Hutkins R. 2017. Health benefits of fermented foods: microbiota and beyond. Curr Opin Biotechnol 44:94–102.
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Naturlig metod för bättre blodcirkulation

Arcangeli P.

1.Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000 Jun;71(3):236-44.

“Effects of Pycnogenol on post-thrombotic syndrome and recurrent thrombosis: A six-year study in at-risk patients”

Minerva Cardioangiologica, 2023

”Prevention of recurrent venous thrombosis and post-thrombotic syndrome”

Minerva Cardioangiol. (2018) Jun;66(3), 238-245

Pourmasoumi M, Hadi A, Mohammadi H, Rouhani MH. Effect of pycnogenol supplementation on blood pressure: A systematic review and meta-analysis of clinical trials. Phytother Res. 2020 Jan;34(1):67-76.

Nr 3 2024 – Stress

Viktiga näringsämnen vid stress

(1)Pouteau E., Kabir-Ahmadi M., Noah L., et.al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018:18;13(12) DOI: 10.1371/journal.pone.0208454

(2)Boyle N.B., Lawton C., Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients. 2017:9;5 doi: 10.3390/nu9050429

(3)Noah L, Dye L., Bois De Fer B., et.al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021:37;5 DOI: 10.1002/smi.3051

(4)Held K., Antonijevic I.A., Künzel H. et.al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacypsychiatry. 2002:35;4 Doi: 10.1055/s-2002-33195

(5)Azargoonjaharomi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024:12;82 DOI: 10.1093/nutrit/nuad076

(6)McCabe D., Lisy K., Lockwood C., Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database of Systematic Reviews and Implementation Reports. 2017:15;2 DOI: 10.11124/JBISRIR-2016-002965

(7)Marik P.E. Vitamin C: an essential ”stress hormone” during sepsis. Journal of Thoracic Disease. 2020:12;1 DOI: 10.21037/jtd.2019.12.64

(8)Brody S., Preut R., Schommer K., Schürmeyer T.H. A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology Ser 2002:159;3 DOI: 10.1007/s00213-001-0929-6

(9)Beglaryan N., Hakobyan G., Nazaretyan E. Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress. Stress Health. 2024:40;3 DOI: 10.1002/smi.3347

(10)Keenan K., Hipwell A., Bortner J., et.al. Association Between Fatty Acid Supplementation and Prenatal Stress in African Americans

A Randomized Controlled Trial. Obstetrics & Gynecology. 2014:124;6 DOI: 10.1097/AOG.0000000000000559

(11)Kiecolt-Glaser J.K., Belury M.A., Andridge R., et.al. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behaviour Immunology. 2011:25;8 DOI: 10.1016/j.bbi.2011.07.229

(12)Young L.M., Pipingas A., White D.J., et.al. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals. Nutrients. 2019:11;9 Doi: 10.3390/nu11092232

(13)Stough C., Scholey A., Lloyd J., et.al. The effect of 90 day administration of a high dose vitamin B-complex on work stress. Human Psychopharmacology. 2011:26;7 DOI: 10.1002/hup.1229

(14)Noah L., Morel V., Bertin C., et.al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals—A Randomized, Placebo-Controlled Study. Nutrients. 2022:14;9 Doi: 10.3390/nu14091863

(15)Dye L., Billington J., Lawton C., Boyle N. A Combination of Magnesium, B Vitamins, Green Tea and Rhodiola Attenuates the Negative Effects of Acute Psychosocial Stress on Subjective State in Adults. Current Developments in Nutrition. 2020:4;2 Doi: 10.1093/cdn/nzaa067_023

(16)Lopresti A., Smith S.J., Malvi H., Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019:98;37 DOI: 10.1097/MD.0000000000017186

(17)Lubarska M., Halasinski P., Hryhorowicz S., et.al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. International Journal of Environmental Research and Public Health. 2023:20;5 Doi: 10.3390/ijerph20053921

(18) McGill University. Why did Denmark ban Ashwagandha? Office for Science and Society, 2023-06-02. https://www.mcgill.ca/oss/article/critical-thinking-health-and-nutrition/why-did-denmark-ban-ashwagandha

(19) LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Ashwagandha. [Updated 2019 May 2]. https://www.ncbi.nlm.nih.gov/books/NBK548536/

(20) Flanagan S.D., DuPont W.H., Caldwell L.K., et.al. The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress. Journal of Medicinal Food. 2018:21;1 DOI: 10.1089/jmf.2017.0071

(21)Lew L-C., Hor Y-Y., Yusoff N.A.A., et.al. Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study. Clinical Nutrition. 2019:38;5 DOI: 10.1016/j.clnu.2018.09.010

(22)Lan Y., Lu J., Qiao G., et.al. Bifidobacterium breve CCFM1025 Improves Sleep Quality via Regulating the Activity of the HPA Axis: A Randomized Clinical Trial. Nutrients. 2023:6;15(21) DOI: 10.3390/nu15214700

10 tips vid stress

1.World Health Organization. Regional Office for Europe. (‎2014)‎. Combined or multiple exposure to health stressors in indoor built environments: an evidence-based review prepared for the WHO training workshop “Multiple environmental exposures and risks”: 16–18 October 2013, Bonn, Germany. World Health Organization. Regional Office for Europe. https://iris.who.int/handle/10665/350495

Paredes-Céspedes D.M., Vélez N., Parada-López A, et.al. The Effects of Nature Exposure Therapies on Stress, Depression, and Anxiety Levels: A Systematic Review. European Journal of Investigative Health and Psychology Education. 2024:14;3 DOI: 10.3390/ejihpe14030040

van der Zwan J.E., de Vente W., Huizink A.C., et.al. Physical activity, mindfulness meditation, or heart rate variability biofeedback for stress reduction: a randomized controlled trial. 2015:40;4 DOI: 10.1007/s10484-015-9293-x

Brist på vitamin B12

[1] Kvestad I, Hysing M, Shrestha M, Ulak M, Thorne-Lyman AL, Henjum S, Ueland PM, Midttun Ø, Fawzi W, Chandyo RK, Shrestha PS, Strand TA. Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children. Am J Clin Nutr. 2017 May;105(5):1122-1131.

2 Casella EB, Valente M, de Navarro JM, Kok F. Vitamin B12 deficiency in infancy as a cause of developmental regression. Brain Dev. 2005 Dec;27(8):592-4.

3 National institute of health. Vitamin B12. (Hämtad 2024-07-30) Vitamin B12 – Health Professional Fact Sheet (nih.gov)

4 Livsmedelsverket. Vitamin B12. (Hämtad 2024-07-30) Vitamin B12 (livsmedelsverket.se)

5Rizzo G, et al. Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrients. 2016;8(12):767.

6 Rauma AL Vitamin B-12 status of long-term adherents of a strict uncooked vegan diet (”living food diet”) is compromised. J Nutr. 7 Wong CW. Vitamin B12 deficiency in the elderly: is it worth screening? Hong Kong Med J. 2015 Apr;21(2):155-64.

7 National Institute for Health and Care excellence. NICE guideline, Vitamin B12 deficiency in over 16s: diagnosis and management, Published: 06 March 2024. (Hämtad 2024-07-30) Recommendations | Vitamin B12 deficiency in over 16s: diagnosis and management | Guidance | NICE

8 Shipton MJ, Thachil J. Vitamin B12 deficiency – A 21st century perspective . Clin Med (Lond). 2015 Apr;15(2):145-50.

9Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009 Feb;89(2):693S-6S

¹[1] Shipton MJ, Thachil J. Vitamin B12 deficiency – A 21st century perspective. Clin Med (Lond). 2015 Apr;15(2):145-50.

1² Herman Nilsson-Ehle. B12- och folatbrist utan anemi. Internetmedicin 2024-02-08. (Hämtad 2024-07-30) B12- och folatbrist utan anemi (internetmedicin.se)

[1]³ Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004655.

[1]⁴ Region Stockholm. Brist på vitamin B12 och folat. (Hämtad 2024-07-30) Brist på vitamin B12 och folat – Viss.nu

[1]⁵ Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89:693S–696S.

[1]⁶ Hunt A, Harrington D, Robinson S. Vitamin B₁₂ deficiency. BMJ. 2014;349:g5226.

[1]⁷ Ströhle A, Richter M, González-Gross M, Neuhäuser-Berthold M, Wagner KH, Leschik-Bonnet E, Egert S; German Nutrition Society (DGE). The Revised D-A-CH-Reference Values for the Intake of Vitamin B₁₂ : Prevention of Deficiency and Beyond. Mol Nutr Food Res. 2019 Mar;63(6):e1801178.

[1]⁸ Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH. Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3(3):CD004655.

Kan kollagentillskott förbättra hudens hälsa?

1.Barati M., Jabbari M., Navekar R., Farahmand F., et.al. Collagen supplementation for skin health: A mechanistic systematic review. 2020:19;11

2.Czajka A., Kania E.M., Genovese L., Corbo A., et.al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018:57;97

3.De Miranda R.B., Weimer P., Rossi R.C. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021:60;12

4.Evans M., Lewis E.D., Zakaria N., Pelipyagina T., Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021:20;3

5. Proksch E., Segger D, Degwert J, Schunck M, et.al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014:27;1

6.Li P., Wu G. Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids. 2018:50;1

7. Bella J., Brodsky B., Berman H.M. Hydration structure of a collagen peptide. Cell Press. 1995:3;9 https://doi.org/10.1016/S0969-2126(01)00224-6

Vitamin K2 ger starkare ben och friskare kärl

[1] Zhou, S., Mehta, B.M. and Feeney, E.L. (2022), A narrative review of vitamin K forms in cheese and their potential role in cardiovascular disease. Int J Dairy Technol, 75: 726-737.

2 Livsmedelsverket, K-vitamin. Hämtad 2024-07-22. K-vitamin (livsmedelsverket.se)

3 Yan Q, Zhang T, O’Connor C, Barlow JW, Walsh J, Scalabrino G, Xu F, Sheridan H. The biological responses of vitamin K2: A comprehensive review. Food Sci Nutr. 2023 Jan 6;11(4):1634-1656.

4 Hariri E, Kassis N, Iskandar JP, Schurgers LJ, Saad A, Abdelfattah O, Bansal A, Isogai T, Harb SC, Kapadia S. Vitamin K2-a neglected player in cardiovascular health: a narrative review. Open Heart. 2021 Nov;8(2):e001715.

5 Proudfoot D, Shanahan CM. Molecular mechanisms mediating vascular calcification: role of matrix Gla protein. Nephrology (Carlton). 2006 Oct;11(5):455-61.

6 Chen H-G, Sheng L-T, Zhang Y-B, et al. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic 7 ⁷ Luo G, Ducy P, McKee MD, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 1997;386:78.

8Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-5.

9 Gast GC A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10.

[1]⁰ Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44.

¹[1] 1177 för vårdpersonel, Osteoporos. Hämtad 2024-07-22. Osteoporos – 1177 för vårdpersonal

[1]² Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507.

[1]³ Knapen MH Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007 Jul;18(7):963-72.

[1]⁴ Yaegashi Y, Onoda T, Tanno K, Kuribayashi T, Sakata K, Orimo H. Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K. Eur J Epidemiol. 2008;23(3):219-25

[1]⁵ Chatterjee K, Mazumder PM, Sarkar SR, Saha R, Chatterjee A, Sarkar B, Banerjee S. Neuroprotective effect of Vitamin K2 against gut dysbiosis associated cognitive decline. Physiol Behav. 2023 Oct 1;269:114252.

[1]⁶ Tsukamoto Y, Ichise H, Kakuda H, Yamaguchi M. Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals. J Bone Miner Metab. 2000;18(4):216-22.

[1]⁷ Zhou, S., Mehta, B.M. and Feeney, E.L. (2022), A narrative review of vitamin K forms in cheese and their potential role in cardiovascular disease. Int J Dairy Technol, 75: 726-737.

Kvinnors stress mitt i livet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298022/

Sov ordentligt om du vill känna dig ung

Rippon I, Steptoe A. Feeling old vs being old: associations between self-perceived age and mortality. JAMA Intern Med. 2015 Feb;175(2):307-9. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2020288
Seyul Kwak, Hairin Kim, Jeanyung Chet, Yoosik Youm:

Feeling How Old I Am: Subjective Age Is Associated With Estimated Brain Age.

Balter LJT, Axelsson J. Sleep and subjective age: protect your sleep if you want to feel young. Proc Biol Sci. 2024 Mar 27;291(2019):20240171.

Nr 2 2024 – Histamin

Bly – en orsak till neurologiska funktionsnedsättningar

[1] Socialstyrelsen, Fortsatt kraftig ökning av adhd-diagnoser, 2023-11-28. Hämtad 2024-05-03. Fortsatt kraftig ökning av adhd-diagnoser – Socialstyrelsen

2 Gundacker C, Forsthuber M, Szigeti T, Kakucs R, Mustieles V, Fernandez MF, Bengtsen E, Vogel U, Hougaard KS, Saber AT. Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility. Int J Hyg Environ Health. 2021 Sep;238:113855.

3 Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental toxicity. Lancet Neurol. 2014 Mar;13(3):330-8.

4 Livsmedelsverket, Bly. Hämtad 2024-05-03. Bly (livsmedelsverket.se)

5 ATSDR. ATSDR Substance Priority List; ATSDR: Atlanta, GA, USA, 2017.

6 Efsa 2012. Lead dietary exposure in the European population. Scientific Report of Efsa. The Efsa Journal 10(7):2831.

7 American Academy of Pediatrics Committee on Environmental Health. Lead exposure in children: Prevention, detection, and management; CCHMC guideline. Pediatrics 2005, 116, 1036.

8 Efsa 2012. Lead dietary exposure in the European population. Scientific Report of Efsa. The Efsa Journal 10(7):2831.

9 Strömberg U, Lundh T, Skerfving S. Yearly measurements of blood lead in Swedish children since 1978: the declining trend continues in the petrol-lead-free period 1995-2007. Environ Res. 2008 Jul;107(3):332-5.

10 Livsmedelsverket. 2020. Contaminants in blood and urine from adolescents in Sweden. Results from the national dietary survey Riksmaten Adolescents 2016-17. Livsmedelsverkets samarbetsrapport S 2020 nr 01.

11 Gulson, B.L.; Mizon, K.J.; Korsch, M.J.; Palmer, J.M.; Donnelly, J.B. Mobilization of lead from human bone tissue during pregnancy and lactation—A summary of long-term research. Sci. Total Environ. 2003, 303, 79–104.

12 Ettinger AS, Hu H, Hernandez-Avila M. Dietary calcium supplementation to lower blood lead levels in pregnancy and lactation. J Nutr Biochem. 2007 Mar;18(3):172-8.

[1]3 EFSA Scientific opinion on lead in food EFSA J, 8 (4) (2010), p. 1570, 10.2903/j.efsa.2010.1570

[1]4 Boverket, Bly i tappvatten. Hämtad 2024-03-12. Bly i tappvatten – Boverket

15Smith MR, Yevoo P, Sadahiro M, Austin C, Amarasiriwardena C, Awawda M, Arora M, Dudley JT, Morishita H. Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity. Sci Rep. 2018 Nov 6;8(1):16388.

16 Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol. 2003;192:1–11.

17 Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain. 2003 Jan;126(Pt 1):5-19.

[1]8 Bellinger DC. Effect modification in epidemiological studies of low-level neurotoxicant exposures and health outcomes. [Review]. Neurotoxicol Teratol 2000; 22: 133±40.

19 Schneider JS, Lee MH, Anderson DW, Zuck L, Lidsky TI. Enriched environment during development is protective against lead-induced neurotoxicity. Brain Res 2001; 896: 48–55.

Vad är Histamin?

1Jarisch R.Histamin-Intoleranz, Histamin und Seekrankheit. 2004. Thiemeverlag.

2Bengtsson U. Histaminintolerans. Näringsmedicinsk tidskrift. 2014;6: 23-24.

3Nylander M. Histaminintolerans. Medicinsk Access. 2015; 4-5: 26-29.

4Hartter E et al. Placebo controlled observational study to proof the efficacy and the absence of side effects of an oral supplementation in histamine intolerance. Report from: Arbeitsmedizinisches Zentrum, 1060 Vienna, Austria. 2005,pp.5-21.

5Ionescu G et al. Cofactor levels of mono- and diamine oxidase in atopic eczema. Allergy. 1989;44:298-300.

6Sattler J et al. Food induced histaminosis as an epidemiological problem: plasmahistamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents Actions. 1988;23:361-365.

7Zimatkin SM & Antichtchik OV. Alcohol-histamine interactions.Alcohol. 1999;34:141-147.

8James SM et al. A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. Science. 1990;248:981-987.

9Komericki P et al. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: A randomised, double-blind, placebo-controlled cross-over study. Wien KlinWochenschr. The Middle European Journal of Medicine.2010. pp 1-6 , DOI 10.1007/s00508-010-1506-y, Springer Verlag, Austria.

10Nylander M. Riktigt Näringsintag & God Munhygien är grundläggande för bästa hälsa. Prod. T&M Media, s. 3–58.

DAO-hämmare

1 Comas-Basté O., Sánchez-Pérez S., Veciana-Nogués M.T., et.al. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020:14;10(8) DOI: 10.3390/biom10081181

2Hrubisko M., Danis R., Huorka M., Wawruch M. Histamine Intolerance—The More We Know the Less We Know. A Review. Nutrients. 2021:13;7 DOI: 10.3390/nu13072228

3 Tobajas Y., Alemany-Fornés M., Samarra I., et.al. Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management. Journal of Clinical Medicine. 2023. DOI: 10.3390/jcm12144666

4International Society of DAO Deficiency. DAO blocking foods – deficitdao.org – Official Scientific Society

5 Zimatkin S.M., Anichtchik O.V. Alcohol-histamine interactions. Alcohol & Alcoholism. 1999:34;2 DOI: 10.1093/alcalc/34.2.141

6Gill D, Barradas M, Fonseca V, Dandona P. Plasma histamine concentrations are elevated in patients with diabetes mellitus and peripheral vascular disease. Metabolism. 1989;38(3):243-247. DOI: 10.1016/0026-0495(89)90082-6

7 Wang K-Y., Tanimoto A., Yamada S., et.al. Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. The American Journal of Pathology. 2010:177;2 DOI: https://doi.org/10.2353/ajpath.2010.091198

8Fogel WA, Chmielecki C, Grałek M, Maslinski C. Histamine metabolism in diabetic rats. Agents and Actions. 1990:243-246. DOI:10.1007/bf01969050

Fibromyalgi – histamin en del av problematiken?

[1] Vårdgivare Skåne, Fibromyalgi. Hämtad 2024-06-07. Fibromyalgi – AKO Skåne-riktlinje för primärvården – Vårdgivare Skåne (skane.se)

2 Okutan G, Ruiz Casares E, Perucho Alcalde T, Sánchez Niño GM, Penadés BF, Terrén Lora A, Torrente Estríngana L, López Oliva S, San Mauro Martín I. Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain. Biomedicines. 2023 Feb 22;11(3):660

3 Conti, P.; Gallenga, C.E.; Caraffa, A.; Ronconi, G.; Kritas, S.K. Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? Dermatol. Ther. 2020, 33, e13191. [CrossRef]

4 Gomez-Arguelles JM, Caceres O, Blanco M, Maestu C, Martin F. Improvement of digestive symptoms in fibromyalgia patients following a diet modification according to histamine release test – an observational study. Reumatologia. 2022;60(3):209-212.

5 Comas-Basté, O.; Sánchez-Pérez, S.; Veciana-Nogués, M.T.; Latorre-Moratalla, M.; Vidal-Carou, M.D.C. Histamine Intolerance: The Current State of the Art. Biomolecules 2020, 10, 1181. [CrossRef] [PubMed]

6 Okutan G, Perucho Alcalde T, Ruiz Casares E, Penadés BF, Sánchez Niño GM, Terrén Lora A, López Oliva S, Torrente Estríngana L, Duelo A, San Mauro Martín I. Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study. Front Genet. 2023 Jun 9;14:1180777.

Adhd och istamin – finns det en koppling?

ADHD

[1] Carthy E, Ellender T. Histamine, Neuroinflammation and Neurodevelopment: A Review. Front Neurosci. 2021 Jul 14;15:680214.

2 Lin, J. S., Anaclet, C., Sergeeva, O. A., and Haas, H. L. (2011). The waking brain: an update. Cell Mol. Life Sci. 68, 2499–2512.

3Takahashi, K., Lin, J. S., and Sakai, K. (2006). Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse. J. Neurosci. 26, 10292–10298.

4 Torrealba, F., Riveros, M. E., Contreras, M., and Valdes, J. L. (2012). Histamine and motivation. Front. Syst. Neurosci. 6:51.

5 Polanczyk, G.V., Willcutt, E.G., Salum, G.A., Kieling, C., Rohde, L.A. ADHD prevalence estimates across three decades: An updated systematic review and meta-regression analysis. Int. J. Epidemiol. 2014, 43, 434–442.

6 Pelsser LM, et. al. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial. Lancet. 2011 Feb 5;377(9764):494-503.

7 Egger J et al. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet 1985 Mar 9;1(8428):540-5

8 Anand D, Colpo GD, Zeni G, Zeni CP, Teixeira AL. Attention-Deficit/Hyperactivity Disorder and Inflammation: What Does Current Knowledge Tell Us? A Systematic Review. Front Psychiatry. 2017 Nov 9;8:228.

9Schmitt J, Buske-Kirschbaum A, Tesch F, Trikojat K, Stephan V, Abraham S, Bauer A, Nemat K, Plessow F, Roessner V. Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use. Allergy. 2018 Mar;73(3):615-626.

10 Blasco-Fontecilla H, Bella-Fernández M, Wang P, Martin-Moratinos M, Li C. Prevalence and Clinical Picture of Diamine Oxidase Gene Variants in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study. J Clin Med. 2024 Mar 14;13(6):1659.

1[1] Izquierdo-Casas, J., Comas-Basté, O.; Latorre-Moratalla, M.L., Lorente-Gascón, M., Duelo, A., Vidal-Carou, M.C., Soler-Singla, L. Low serum diamine oxidase (DAO) activity levels in patients with migraine. J. Physiol. Biochem. 2018, 74, 93–99.

Naturligt barkextrakt kan hjälpa mot pollenallergi

1A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms.

Phytother Res. 2010 Aug;24(8):1115-9.

2The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects.

Phytother Res. 2022 Jun;36(6):2352-2374.

3Pycnogenol® improvements in asthma management

Panminerva Medica, 01 Sep 2011, 53(3 Suppl 1):57-64

4Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women

Skin Pharmacol Physiol 2012;25(2):86-92.

Samma mat olika blodsocker

[1] Maja Wahlström, Susanna Palmer. Diabetes typ 2 i primärvård – utredning och uppföljning Dec 2022. Hämtad 2024-04-29. Diabetes typ 2 i primärvård – utredning och uppföljning (internetmedicin.se)

[1] National Diabetes Statistics Report, Estimates of Diabetes and Its Burden in the United States. Hämtad 2024-04-29. National Diabetes Statistics Report | Diabetes | CDC

[1] Guizar-Heredia R, Noriega LG, Rivera AL, Resendis-Antonio O, Guevara-Cruz M, Torres N, Tovar AR. A New Approach to Personalized Nutrition: Postprandial Glycemic Response and its Relationship to Gut Microbiota. Arch Med Res. 2023 Apr;54(3):176-188.

[1] Zeevi D et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015 Nov 19;163(5):1079-1094.

[1] Vrolix R, Mensink RP. Variability of the glycemic response to single food products in healthy subjects. Contemp Clin Trials. 2010 Jan;31(1):5-11.

[1] Mendes-Soares H, Raveh-Sadka T, Azulay S, Edens K, Ben-Shlomo Y, Cohen Y, Ofek T, Bachrach D, Stevens J, Colibaseanu D, Segal L, Kashyap P, Nelson H. Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes. JAMA Netw Open. 2019 Feb 1;2(2):e188102.

[1] Shishehbor F, Mansoori A, Shirani F. Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials. Diabetes Res Clin Pract. 2017 May;127:1-9.

[1] Nitta A, Imai S, Kajiayama S, Matsuda M, Miyawaki T, Matsumoto S, Kajiyama S, Hashimoto Y, Ozasa N, Fukui M. Impact of Dietitian-Led Nutrition Therapy of Food Order on 5-Year Glycemic Control in Outpatients with Type 2 Diabetes at Primary Care Clinic: Retrospective Cohort Study. Nutrients. 2022 Jul 13;14(14):2865.

[1] Meng H, Matthan NR, Ausman LM, Lichtenstein AH. Effect of prior meal macronutrient composition on postprandial glycemic responses and glycemic index and glycemic load value determinations. Am J Clin Nutr. 2017 Nov;106(5):1246-1256.

[1] Sung J, Kim S, Cabatbat JJT, et al. Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017;8:15393.

[1] Khan MT, Nieuwdorp M, Bäckhed F. Microbial modulation of insulin sensitivity. Cell Metab. 2014;20(5):753-760.

[1] Shuiming Xiao, Na Fei, Xiaoyan Pang, Jian Shen, Linghua Wang, Baorang Zhang, Menghui Zhang, Xiaojun Zhang, Chenhong Zhang, Min Li, Lifeng Sun, Zhengsheng Xue, Jingjing Wang, Jie Feng, Feiyan Yan, Naisi Zhao, Jiaqi Liu, Wenmin Long, Liping Zhao, A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome, FEMS Microbiology Ecology, Volume 87, Issue 2, February 2014, Pages 357–367.

[1] Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011 Oct 7;334(6052):105-8.

[1] Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol. 2007 Feb;73(4):1073-8.

Oxymel – En antik vinägrett med superkraft

1Darani NS, Vaghasloo MA, Kazemi A, Amri H, Rampp T, Hashempur MH. Oxymel: A systematic review of preclinical and clinical studies. Heliyon. 2023 Nov 21;9(12):e22649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730569/

2Nejatbakhsh F, Karegar-Borzi H, Amin G, Eslaminejad A, Hosseini M, Bozorgi M, Gharabaghi MA. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Ethnopharmacol. 2017 Jan 20;196:186-192.

3Chen Q, Zhou K. Acetic Acid Use in Chronic Wound Healing: A Multiple Case Series. J Wound Ostomy Continence Nurs. 2022 May-Jun 01;49(3):286-289.

4Harrison F, Blower A, de Wolf C, Connelly E. Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys. Microbiology (Reading). 2023 Jul;169(7):001351.

5Smaropoulos E, Cremers NAJ. Treating severe wounds in pediatrics with medical grade honey: A case series. Clin Case Rep. 2020 Jan 31;8(3):469-476.

5Deluca L. Ancient Honey-and-Vinegar Combo Could Actually Treat Infected Wounds. Scientific American 2023-10-01. https://www.scientificamerican.com/article/ancient-honey-and-vinegar-combo-could-actually-treat-infected-wounds/

7Darani NS, Vaghasloo MA, Kazemi A, Amri H, Rampp T, Hashempur MH. Oxymel: A systematic review of preclinical and clinical studies. Heliyon. 2023 Nov 21;9(12):e22649.

8Guan BM. Oxymel: A Not-So-New Natural Treatment for Infection. Institute for Natural Medicine 2024-01-18. https://naturemed.org/oxymel-a-not-so-new-natural-treatment-for-infection/

Kan ubiquinol Q10 förbättra kvaliteten på spermierna?

[1] Internetmedicin. Infertilitet, manlig. Hämtad 2023-11-08. https://www.internetmedicin.se/behandlingsoversikter/endokrinologi/infertilitet-manlig

[1] Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations – PubMed (nih.gov)

[1] Hosoe K. et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers – PubMed (nih.gov)

[1] Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial – PubMed (nih.gov)

[1] García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency – PubMed (nih.gov)

[1] Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men – PubMed (nih.gov)

[1] 1177. Så fungerar det manliga könsorganet. Hämtad 2023-11-08.

https://www.1177.se/liv–halsa/sa-fungerar-kroppen/sa-fungerar-konsorganen/sa-fungerar-det-manliga-konsorganet/

[1] Hirata S et al. Spermatozoon and mitochondrial DNA. Reprod Med Biol. 2002 Dec 11;1(2):41-47. Spermatozoon and mitochondrial DNA – PMC (nih.gov)

[1] Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. Oocyte mitochondrial function and reproduction – PMC (nih.gov)

[1] Vishvkarma R et al. Coenzyme Q10 effect on semen parameters: Profound or meagre? Andrologia. 2020;52:e13570. Coenzyme Q10 effect on semen parameters: Profound or meagre? – PubMed (nih.gov)

[1] Kao SH et al. Increase of oxidative stress in human sperm with lower motility. Fertil Steril. 2008 May;89(5):1183-1190. Increase of oxidative stress in human sperm with lower motility – Fertility and Sterility (fertstert.org)

[1] Nowicka-Bauer K, Nixon B. Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility. Antioxidants (Basel). 2020 Feb 4;9(2):134. Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility – PubMed (nih.gov)

[1] Alahmar AT et al. Coenzyme Q10, oxidative stress, and male infertility: A review. Clin Exp Reprod Med. 2021 Jun;48(2):97-104. Coenzyme Q10, oxidative stress, and male infertility: A review – PubMed (nih.gov)

[1] Alahmar AT et al. Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia. Clin Exp Reprod Med. 2021 Jun;48(2):150-155. Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia – PubMed (nih.gov)

[1] Alahmar AT, Naemi R. Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre- and post-coenzyme Q10 therapy. Andrologia. 2022 Jun;54(5):e14385. Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy – PMC (nih.gov)

Nr 4 2023/1 2024 – Längre liv: Anti-aging & Longevity

Medeltida medicin i modern tappning – Ögonsalva från 800-talet dödar dagens mördarbakterier

1. Connelly E, Lee C, Furner-Pardoe J, Del Genio CI, Harrison F. A case study of the Ancientbiotics collaboration. Patterns (N Y). 2022 Dec 9;3(12):100632.

2. https://www.nottingham.ac.uk/news/pressreleases/2015/march/ancientbiotics—a-medieval-remedy-for-modern-day-superbugs.aspx

3. Harrison F, Roberts AE, Gabrilska R, Rumbaugh KP, Lee C, Diggle SP. A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity. mBio. 2015 Aug 11;6(4):e01129.

4. Dalton T, Dowd SE, Wolcott RD, Sun Y, Watters C, Griswold JA, Rumbaugh KP. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One. 2011;6(11):e27317.

5. Furner-Pardoe J, Anonye BO, Cain R, Moat J, Ortori CA, Lee C, Barrett DA, Corre C, Harrison F. Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Sci Rep. 2020 Jul 28;10(1):12687.

6. Rémy B, Mion S, Plener L, Elias M, Chabrière E, Daudé D. Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective. Front Pharmacol. 2018 Mar 7;9:203.

7. Anonye BO, Nweke V, Furner-Pardoe J, Gabrilska R, Rafiq A, Ukachukwu F, Bruce J, Lee C, Unnikrishnan M, Rumbaugh KP, Snyder LAS, Harrison F. The safety profile of Bald’s eyesalve for the treatment of bacterial infections. Sci Rep. 2020 Oct 15;10(1):17513.

Kan vitaminer och mineraler hålla dig ung?

1. “Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens”

International Journal of Cardiology, 2013

2. ”The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial”

JACC, Heart Failure, 2014

3. “Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial”

Nutrients, 2022

4. “Association of dietary selenium intake with telomere length I middle-aged and older adults”

Clinical Nutrition, januari 2020

Bison och syrsor på menyn – ”Smakar som en discokula i skogen”

1. Food as a Catalyst for Change, en föreläsning arrangerad av The Peace Research Institute Oslo (PRIO), 5 Sep 2022. https://www.prio.org/events/8964

2. Kormann C. How Owamni Became the Best New Restaurant in the United States. The New Yorker, 2022-11-12. https://www.newyorker.com/magazine/2022/09/19/how-owamni-became-the-best-new-restaurant-in-the-united-states

3. U.S. Department of Health & Human Services. Diabetes and American Indians/Alaska Natives

https://minorityhealth.hhs.gov/diabetes-and-american-indiansalaska-natives Hämtad 2024-02-13.

4. U.S. Department of Health & Human Services. Heart Disease and American Indians/Alaska Natives.

https://minorityhealth.hhs.gov/heart-disease-and-american-indiansalaska-natives Hämtad 2024-02-13.

Glycin och NAC för hälsosamt åldrande

1. Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78 (1):75-89.

2. Nguyen D, Samson SL, Reddy VT, Gonzalez EV, Sekhar RV. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. Aging Cell. 2013 Jun;12(3):415-25.

3. Meléndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009 Dec;34(6):853-72.

4. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701.

5. Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16.

6. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356.

7. Oliver G, Dean O, Camfield D, Blair-West S, Ng C, Berk M, Sarris J. N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):12-24.

8. Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, Jongejan A, Weeghel MV, MacInnes AW, Houtkooper RH. Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet. 2019 Mar 7;15(3):e1007633.

9. Oh SI, Park JK, Park SK. Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo). 2015 May;70(5):380-6.

10. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022 Mar 7;14(5):1114.

11. Lizzo G, Migliavacca E, Lamers D, Frézal A, Corthesy J, Vinyes-Parès G, Bosco N, Karagounis LG, Hövelmann U, Heise T, von Eynatten M, Gut P. A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. Front Aging. 2022 Mar 7;3:852569.

12. Baylor College of Medicine. GlyNAC supplementation reverses aging hallmarks in aging humans. Pressmeddelande 2022-08-17. https://www.bcm.edu/news/glynac-supplementation-reverses-aging-hallmarks-in-aging-humans

Ökad fertilitet med ubiquinol Q10?

1. SCB, Utan barn – skillnader i barnlöshet mellan kvinnor och män i olika grupper Demografiska rapporter 2020:1 Utan barn (scb.se)

2. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations – PubMed (nih.gov)

3. Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. Oocyte mitochondrial function and reproduction – PMC (nih.gov)

4. Pizzorno J. Mitochondria-Fundamental to Life and Health. Integr Med (Encinitas). 2014 Apr;13(2):8-15. Mitochondria—Fundamental to Life and Health – PMC (nih.gov)

5. May-Panloup P et al. Embryo and Its Mitochondria. Antioxidants (Basel). 2021 Jan 20;10(2):139. Embryo and Its Mitochondria – PMC (nih.gov)

6. Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging – PubMed (nih.gov)

7. Bonomi M et al. Blood cell mitochondrial DNA content and premature ovarian aging. PLoS One. 2012;7(8):e42423. Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging – PMC (nih.gov)

8. Thakur AS et al. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Indian J Clin Biochem. 2016 Jul;31(3):342-8. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients – PMC (nih.gov)

9. Xu Y et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018 Mar 27;16(1):29. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial – PMC (nih.gov)

10. Ozdemir A et al. (2019) Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility. Open Journal of Obstetrics and Gynecology, 9, 1-9. Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility (scirp.org)

11. Hosoe K et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers – PubMed (nih.gov)

12. Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial – PubMed (nih.gov)

13. Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men – PubMed (nih.gov)

14. García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency – PubMed (nih.gov)

Kan vi hålla oss unga med Q10 och selen?

1.Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6.

2. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP; Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9.

3. Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U. Selenium and Coenzyme Q10Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial. Nutrients. 2022 Aug 15;14(16):3346.

4. Shu Y, Wu M, Yang S, Wang Y, Li H. Association of dietary selenium intake with telomere length in middle-aged and older adults. Clin Nutr. 2020 Oct;39(10):3086-3091.

Sköldkörteln behöver selen

1. Effect of levothyroxine sodium combined

with selenium supplement.International Journal of Clinical and Experimental Medicine, 2020;13(7):4695-4703

2. Derumeaux H, Valeix P, Castetbon K, Bensimon M, Boutron-Ruault MC, Arnaud J, Hercberg S. Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults. Eur J Endocrinol. 2003 Mar;148(3):309-15. 3 Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6. 4 Outzen M, Tjønneland A, Larsen EH, Andersen KK, Christensen J, Overvad K, Olsen A. The effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake. Nutrients. 2015 Jan 15;7(1):608-24.

Avokado ger bättre hud

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664913/

Nr 3, 2023: Starkare och friskare lungor

Ta hand om tarmen – skydda dina lungor:

1. Caffaratti C, Plazy C, Mery G, Tidjani AR, Fiorini F, Thiroux S, Toussaint B, Hannani D, Le Gouellec A. What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk. Metabolites. 2021 Jun 21;11(6):406.

2. Zhang F, Lau RI, Liu Q, Su Q, Chan FKL, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023 May;20(5):323-337.

3. Ni S, Yuan X, Cao Q, Chen Y, Peng X, Lin J, Li Y, Ma W, Gao S, Chen D. Gut microbiota regulate migration of lymphocytes from gut to lung. Microb Pathog. 2023 Aug 23;183:106311.

4. Bowerman KL, Rehman SF, Vaughan A, Lachner N, Budden KF, Kim RY, Wood DLA, Gellatly SL, Shukla SD, Wood LG, Yang IA, Wark PA, Hugenholtz P, Hansbro PM. Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease. Nat Commun. 2020 Nov 18;11(1):5886.

5. Demirci, M. et al. Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma. Allergol. Immunopathol. 47, 365–371 (2019).

6. Trompette, A. et al. Dietary fiber confers protection against flu by shaping Ly6c(−) patrolling monocyte hematopoiesis and CD8(+) T cell metabolism. Immunity. 2018;48:992–1005. e1008.

7. Spacova I, Van Beeck W, Seys S, Devos F, Vanoirbeek J, Vanderleyden J, Ceuppens J, Petrova M, Lebeer S. Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model. Gut Microbes. 2020 Nov 1;11(6):1729-1744.

8. Xie Q, Yuan J, Wang Y. Treating asthma patients with probiotics: a systematic review and meta-analysis. Nutr Hosp. 2023 Aug 28;40(4):829-838. English.

9. Wawryk-Gawda E, Markut-Miotła E, Emeryk A. Postnatal probiotics administration does not prevent asthma in children, but using prebiotics or synbiotics may be the effective potential strategies to decrease the frequency of asthma in high-risk children – a meta-analysis of clinical trials. Allergol Immunopathol (Madr). 2021 Jul 1;49(4):4-14.

10.Haberman, Y., Kamer, I., Amir, A. et al. Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit. Sci Rep 13, 2007 (2023).

11.Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019 Feb 21;176(5):998-1013.e16.

12.Liu X, Cheng Y, Zang D, Zhang M, Li X, Liu D, Gao B, Zhou H, Sun J, Han X, Lin M, Chen J. The Role of Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy. Front Oncol. 2021 Aug 19;11:720842.

13.Tsay, T. B., Yang, M. C., Chen, P. H., Hsu, C. M. & Chen, L. W. Gut flora enhance bacterial clearance in lung through toll-like receptors 4. J. Biomed. Sci. 2011;18:68.

14.Ichinohe, T. et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc. Natl Acad. Sci. USA. 2011;108:5354–5359.

15.Sencio V, Machado MG, Trottein F. The lung-gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes. Mucosal Immunol. 2021 Mar;14(2):296-304. doi: 10.1038/s41385-020-00361-8. Epub 2021 Jan 26. PMID: 33500564; PMCID: PMC7835650.

16.Boucher E, Plazy C, Le Gouellec A, Toussaint B, Hannani D. Inulin Prebiotic Protects against Lethal Pseudomonas aeruginosa Acute Infection via γδ T Cell Activation. Nutrients. 2023 Jul 5;15(13):3037. doi: 10.3390/nu15133037. PMID: 37447363; PMCID: PMC10346238.

17.Kim Y.J., Lee J.Y., Lee J.J., Jeon S.M., Silwal P., Kim I.S., Kim H.J., Park C.R., Chung C., Han J.E., et al. Arginine-Mediated Gut Microbiome Remodeling Promotes Host Pulmonary Immune Defense against Nontuberculous Mycobacterial Infection. Gut Microbes. 2022;14:2073132.

18.Zhang F, Lau RI, Liu Q, Su Q, Chan FKL, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023 May;20(5):323-337. doi: 10.1038/s41575-022-00698-4. Epub 2022 Oct 21. Erratum in: Nat Rev Gastroenterol Hepatol. 2023 Mar;20(3):195.

Miljögifter:

Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., Roberts, S. M. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. Environmental toxicology and chemistry. 2021;40(3):606–630.

2. Eve L, Fervers B, Le Romancer M, Etienne-Selloum N. Int J Mol Sci. 2020;21(23):9139.

3. Montero-Montoya R, López-Vargas R, Arellano-Aguilar O. Volatile Organic Compounds in Air: Sources, Distribution, Exposure and Associated Illnesses in Children. Ann Glob Health. 2018;84(2):225-238. Published 2018 Jul 27.

4. Balali-Mood M, Naseri K, Tahergorabi Z, Khazdair MR, Sadeghi M. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021;12:643972.

5. Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689.

6. Baer-Dubowska, W., Szaefer, H.Modulation of carcinogen-metabolizing cytochromes P450 by phytochemicals in humans. Expert opinion on drug metabolism & toxicology 2013;9(8): 927–941.

7. Walters, D. G., Young, P. J., Agus, C., Knize, M. G., Boobis, A. R., Gooderham, N. J., & Lake, B. G. Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. Carcinogenesis 2004;25(9): 1659–1669.

8. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997;94(19):10367-10372.

9. Kleszczyński, K., Ernst, I. M., Wagner, A. E., Kruse, N., Zillikens, D., Rimbach, G., Fischer, T. W. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacological research 2013;78: 28–40.

10. Riedl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009;130(3):244-251.

11. Egner, P. A., Chen, J. G., Zarth, A. T., Ng, D. K., Wang, J. B., Kensler, K. H., Jacobson, L. P., Muñoz, A., Johnson, J. L., Groopman, J. D., Fahey, J. W., Talalay, P., Zhu, J., Chen, T. Y., Qian, G. S., Carmella, S. G., Hecht, S. S., Kensler, T. W. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer prevention research (Philadelphia, Pa.) 2014; 7(8): 813–823.

12. Wu, G., Fang, Y. Z., Yang, S., Lupton, J. R., & Turner, N. D. Glutathione metabolism and its implications for health. The Journal of nutrition 2004;134(3): 489–492.

13. Richie, J. P., Jr, Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J. S., Schell, T. D., Muscat, J. E. . Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European journal of nutrition. 2015;54(2): 251–263.

14. Burns J, Yokota T, Ashihara H, Lean ME, Crozier A.. Plant foods and herbal sources of resveratrol. Journal of agricultural and food chemistry. 2002;50(11): 3337–3340.

15. Chow HH, Garland LL, Hsu CH, et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010;3(9):1168-1175.

16. Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson, IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 2008;294(3): L478–L488.

17. Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019;11(9):2073.

18. Misra UK, Kalita J, Singh, S K, Rahi, S K. Oxidative Stress Markers in Vitamin B12 Deficiency. Molecular neurobiology, 2017;54(2), 1278–1284.

Adaptogena örter för ökad lunghälsa:

1. Bruce J, Oyedemi B, Parsons N, Harrison F. Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers. Sci Rep. 2022 Nov 16;12(1):19656.

2. Silveira D, Prieto-Garcia JM, Boylan F, Estrada O, Fonseca-Bazzo YM, Jamal CM, Magalhães PO, Pereira EO, Tomczyk M, Heinrich M. COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy? Front Pharmacol. 2020 Sep 23;11:581840.

3. Prajapati SK, Malaiya A, Mishra G, Jain D, Kesharwani P, Mody N, Ahmadi A, Paliwal R, Jain A. An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations. J Ethnopharmacol. 2022 Oct 5;296:115420.

4. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017;1401:49–64.

5. Panossian A, Brendler T. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals (Basel). 2020 Sep 8;13(9):236.

6. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel). 2010 Jan 19;3(1):188-224.

7. Liao LY, He YF, Li L, Meng H, Dong YM, Yi F, Xiao PG. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018 Nov 16;13:57.

8. Panossian A, Efferth T. Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity. Pharmaceuticals (Basel). 2022 Aug 25;15(9):1051.

9. Panossian A. Challenges in phytotherapy research. Front Pharmacol. 2023 May 31;14:1199516.

10.Panossian A, Brendler T. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals (Basel). 2020 Sep 8;13(9):236.

11.NIH. Health information. Asian ginseng. https://www.nccih.nih.gov/health/asian-ginseng

12.Gomaa AA, Abdel-Wadood YA. The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions. Phytomed Plus. 2021 Aug;1(3):100043.

13.Chuang ML, Wu TC, Wang YT, Wang YC, Tsao TC, Wei JC, Chen CY, Lin IF. Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease–A Randomized Placebo Controlled Double Blind Clinical Trial. PLoS One. 2015 Jun 22;10(6):e0128142.

14.Ratiani L, Pachkoria E, Mamageishvili N, Shengelia R, Hovhannisyan A, Panossian A. Efficacy of Kan Jang® in Patients with Mild COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial. Pharmaceuticals (Basel). 2023 Aug 22;16(9):1196.

Nr 2, 2023: Svampar – de goda och de ond

Svamparnas läkande kraft:

Svamparnas läkande kraft:

1. Gründemann C, Reinhardt JK, Lindequist U. European medicinal mushrooms: Do they have potential for modern medicine? – An update. Phytomedicine. 2020 Jan;66:153131.

2. AMERICAN PHYSIOLOGICAL SOCIETY. Rare Chinese mushroom derivative can improve capacity, endurance, in sedentary elderly. Pressmeddelande 2004-04-19. https://www.eurekalert.org/news-releases/481021

3. Das G, Shin HS, Leyva-Gómez G, Prado-Audelo MLD, Cortes H, Singh YD, Panda MK, Mishra AP, Nigam M, Saklani S, Chaturi PK, Martorell M, Cruz-Martins N, Sharma V, Garg N, Sharma R, Patra JK. Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Front Pharmacol. 2021 Feb 8;11:602364.

4. Anusiya G, Gowthama Prabu U, Yamini NV, Sivarajasekar N, Rambabu K, Bharath G, Banat F. A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 2021 Dec;12(2):11239-11268.

5. Xia Y, Wang D, Li J, Chen M, Wang D, Jiang Z, Liu B. Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation. Front Pharmacol. 2022 Sep 9;13:974794.

6. Stier H, Ebbeskotte V, Gruenwald J. Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan. Nutr J. 2014 Apr 28;13:38.

7. Bains A, Chawla P, Kaur S, Najda A, Fogarasi M, Fogarasi S. Bioactives from mushroom: health attributes and food industry applications. Materials. 2021;14:247640.

8. De Marco Castro E, Calder PC, Roche HM. β-1,3/1,6-glucans and immunity: state of the art and future directions. Mol Nutr Food Res.2021;65:1901071.

9. Bashir KMI, Choi JS. Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future. Int J Mol Sci. 2017 Sep 5;18(9):1906.

10. Egra S, Kussuma IW, Arung E, Kuspradini H. The potential of white-oyster mushroom (Pleurotus ostreatus) as antimicrobial and natural antioxidant. Biofarmasi J Nat Prod Biochem. 2019;17:102.

11. Kalaras MD, Richie JP, Calcagnotto A, Beelman RB. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chem. 2017 Oct 15;233:429-433.

12. Liu HM, Tang W, Wang XY, Jiang JJ, Zhang W, Wang W. Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin. Molecules. 2023 Feb 8;28(4):1648.

13. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022 Mar 18;13:850813.

14. Kalaras MD, Richie JP, Calcagnotto A, Beelman RB. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chem. 2017 Oct 15;233:429-433.

15. Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7.

16. Radhi M, Ashraf S, Lawrence S, Tranholm AA, Wellham PAD, Hafeez A, Khamis AS, Thomas R, McWilliams D, de Moor CH. A Systematic Review of the Biological Effects of Cordycepin. Molecules. 2021 Sep 28;26(19):5886.

17. Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome. Sci Rep. 2016 Aug 11;6:29540.

18. Bell V, Ferrão J, Chaquisse E, Manuel B, Fernandes T. Role of mushrooms in autism. Austin J Nutr Food Sci. 2019;6:1128.

19. Cui Y, Kim DS, Park KC. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol J Ethnopharmacol. (2005) 96:79–85.

20. Duarte AP, Luís Â, Gallardo E, Alhallaf W, Perkins LB. The anti-inflammatory properties of Chaga extracts obtained by different extraction methods against LPS-induced RAW 2647. Molecules.2022;27:4207.

21. Lu Y, Jia Y, Xue Z, Li N, Liu J, Chen H. Recent developments in Inonotus obliquus (Chaga mushroom) polysaccharides: isolation, structural characteristics, biological activities and application. Polymers. 2021;13:91441.

22. Shahzad F, Anderson D, Najafzadeh M. The antiviral, anti-inflammatory effects of natural medicinal herbs and mushrooms and SARS-CoV-2 infection. Nutrients. 2020;12:2573.

23. Ham SS, Kim SH, Moon SY, Chung MJ, Cui CB, Han EK, et al.. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res Toxicol Environ Mutagen. 2009;672:55–9.

24. Yu WS, Fung ML, Lee CW, Lim LW, Wong KH. The monkey head mushroom and memory enhancement in Alzheimer’s disease. Cells. (2022) 11:2284.

25. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72.

26. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155.

27. Tian B, Wang P, Xu T, Cai M, Mao R, Huang L, Sun P, Yang K. Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide. Food Funct. 2023 Mar 20;14(6):2921-2932.

28. Ren Z, Xu Z, Amakye WK, Liu W, Zhao Z, Gao L, Wang M, Ren J. Hericium erinaceus mycelium-Derived Polysaccharide Alleviates Ulcerative Colitis and Modulates Gut Microbiota in Cynomolgus Monkeys. Mol Nutr Food Res. 2023 Feb;67(3):e2200450.

29. Dasgupta A, Acharya K. Mushrooms: an emerging resource for therapeutic terpenoids. Biotech. 2019;9:2.

30. Darshani P, Sen Sarma S, Srivastava AK, Baishya R, Kumar D. Anti-viral triterpenes: a review. Phytochem Rev. 2022:1–82.

31. Choengpanya K, Ratanabunyong S, Seetaha S, Tabtimmai L, Choowongkomon K. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi J Biol Sci. (2021) 28:2807.

32. Shahzad F, Anderson D, Najafzadeh M. The antiviral, anti-inflammatory effects of natural medicinal herbs and mushrooms and SARS-CoV-2 infection. Nutrients. 2020;12:2573.

33. Jakopovic B, Oršolić N, Kraljević Pavelić S. Antitumor, immunomodulatory and antiangiogenic efficacy of medicinal mushroom extract mixtures in advanced colorectal cancer animal model. Molecules. 2020;25:5005.

34. Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87.

35. Diallo I, Boudard F, Morel S, Vitou M, Guzman C, Saint N, Michel A, Rapior S, Traoré L, Poucheret P, Fons F. Antioxidant and Anti-Inflammatory Potential of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Sporophores from Various Culture Conditions. Int J Med Mushrooms. 2020;22(6):535-546.

36. Choi JY, Paik DJ, Kwon DY, Park Y. Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. Nutr J. 2014 Apr 22;13:35.

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39. Bing-Ji Ma ,Jin-Wen Shen,Hai-You Yu,Yuan Ruan,Ting-Ting Wu &Xu Zhao. Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycology. 2009;1;2:92-98.

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Cancer & Svamp

Dohlman AB, Klug J, Mesko M, Gao IH, Lipkin SM, Shen X, Iliev ID. A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell. 2022 Sep 29;185(20):3807-3822.e12.

Straussman R. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell. 2022 Sep 29;185(20):3789-3806.e17.

Weill Cornell Medicine. Fungal Association with Tumors May Predict Worse Outcomes. Pressmeddelande 2022-09-29.

Weizmann Institute of Science. The findings demonstrate that fungi are living in tumors and may facilitate cancer detection, diagnosis and perhaps even treatment. Pressmeddelande 2022-09-29.

Zimmer C. A New Approach to Spotting Tumors: Look for Their Microbes. New York Times 2022-09-29.

Svampväxt i cancertumörer

Kan psykobiotika minska depression och ångest?

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Nr 1, 2023: Hjärnhälsa

Lösningen på alzheimer

[1] https://drtalks.com/overcoming-long-haul-syndrome-summit-2023/

2 Gomes Gonçalves N, Vidal Ferreira N, Khandpur N, Martinez Steele E, Bertazzi Levy R, Andrade Lotufo P, Bensenor IM, Caramelli P, Alvim de Matos SM, Marchioni DM, Suemoto CK. Association Between Consumption of Ultraprocessed Foods and Cognitive Decline. JAMA Neurol. 2023 Feb 1;80(2):142-150.

3 Moir RD, Lathe R, Tanzi RE. The antimicrobial protection hypothesis of Alzheimer’s disease. Alzheimers Dement. 2018 Dec;14(12):1602-1614.

4 65% of those affected are women1. 1 Prince MA., 2014. World Alzheimer Report 2014 United Kingdom: Alzheimer’s Disease International.

5Ghahremani M, Smith EE, Chen HY, Creese B, Goodarzi Z, Ismail Z. Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status. Alzheimers Dement (Amst). 2023 Mar 1;15(1):e12404.

6 An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O’Brien R, Thambisetty M. Evidence for brain glucose dysregulation in Alzheimer’s disease. Alzheimers Dement. 2018 Mar;14(3):318-329..

7 Piller C. Revised clinical trial form for Alzheimer’s antibody warned of fatal brain bleeds. Science 2022-12-30. https://www.science.org/content/article/revised-clinical-trial-form-alzheimer-s-antibody-warned-fatal-brain-bleeds

8 Dale Bredesens Facebook-sida, 1 dec 2022.

9 Sala-Vila A, Satizabal CL, Tintle N, Melo van Lent D, Vasan RS, Beiser AS, Seshadri S, Harris WS. Red Blood Cell DHA Is Inversely Associated with Risk of Incident Alzheimer’s Disease and All-Cause Dementia: Framingham Offspring Study. Nutrients. 2022 Jun 9;14(12):2408

10 Sala-Vila A, Arenaza-Urquijo EM, Sánchez-Benavides G, Suárez-Calvet M, Milà-Alomà M, Grau-Rivera O, González-de-Echávarri JM, Crous-Bou M, Minguillón C, Fauria K, Operto G, Falcón C, Salvadó G, Cacciaglia R, Ingala S, Barkhof F, Schröder H, Scarmeas N, Gispert JD, Molinuevo JL; ALFA study. DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease. Am J Clin Nutr. 2021 Jun 1;113(6):1627-1635.

11 Weaver DF et al. Alzheimer’s disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites. Alzheimers Dement (N Y). 2022 Apr 6;8(1):e12283.

12 Moir RD, Lathe R, Tanzi RE. The antimicrobial protection hypothesis of Alzheimer’s disease. Alzheimers Dement. 2018 Dec;14(12):1602-1614.

[1]3 Wu C, Jiang ML, Jiang R, Pang T, Zhang CJ. The roles of fungus in CNS autoimmune and neurodegeneration disorders. Front Immunol. 2023 Jan 26;13:1077335.

14 Benson D. Conversation with Dale Bredesen, MD. Integr Med (Encinitas). 2021 Oct;20(5):44-47.

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Äntligen en klinisk studie

[1]5 Rao et al. 2021. ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533598/

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[1]7 Martin P, Sandström H. Föryngring inom räckhåll – så minskar du din biologiska ålder. Hälsa & Funktionsmedicin nr 2 2002.

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När östrogenet sjunker förändras hjärnan

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Nr 4, 2022: Huden

James Nestor: ”Så påverkar andningen din hälsa”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401711/

Atopiskt eksem och näringsmedicin: En klinisk överblick

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Huden ‒ en hel hormonfabrik som aktiveras av solsken

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Nr 3, 2022: Träning och rörelse

Precisionshälsa – framtidens friskvård är redan här

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Fyra träningsformer för bättre fysik – vilken passar dig?

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Wang C, Xing J, Zhao B, Wang Y, Zhang L, Wang Y, Zheng M, Liu G. The Effects of High-Intensity Interval Training on Exercise Capacity and Prognosis in Heart Failure and Coronary Artery Disease: A Systematic Review and Meta-Analysis. Cardiovasc Ther. 2022 Jun 9;2022:4273809.
Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011;2011:868305.
Shiroma EJ, Lee IM. Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity. Circulation. 2010 Aug 17;122(7):743-52.
Sharma A, Madaan V, Petty FD. Exercise for mental health. Prim Care Companion J Clin Psychiatry. 2006;8(2):106.
Reed J, Ones DS. The effect of acute aerobic exercise on positive activated affect: A meta-analysis. Psychology of Sport and Exercise, 2006; 7(5), 477-514. https://doi.org/10.1016/j.psychsport.2005.11.003
Gschwind YJ, Kressig RW, Lacroix A, Muehlbauer T, Pfenninger B, Granacher U. A best practice fall prevention exercise program to improve balance, strength / power, and psychosocial health in older adults: study protocol for a randomized controlled trial. BMC Geriatr. 2013 Oct 9;13:105.
Heitkamp HC, Horstmann T, Mayer F, Weller J, Dickhuth HH. Gain in strength and muscular balance after balance training. Int J Sports Med. 2001 May;22(4):285-90. doi: 10.1055/s-2001-13819. PMID: 11414672.
Chen HM, Wang HH, Chen CH, Hu HM. Effectiveness of a stretching exercise program on low back pain and exercise self-efficacy among nurses in Taiwan: a randomized clinical trial. Pain Manag Nurs. 2014 Mar;15(1):283-91.
Opplert J, Babault N. Acute Effects of Dynamic Stretching on Muscle Flexibility and Performance: An Analysis of the Current Literature. Sports Med. 2018 Feb;48(2):299-325. doi: 10.1007/s40279-017-0797-9. PMID: 29063454.
Choi W. Effect of 4 Weeks of Cervical Deep Muscle Flexion Exercise on Headache and Sleep Disorder in Patients with Tension Headache and Forward Head Posture. Int J Environ Res Public Health. 2021 Mar 25;18(7):3410.
Kizhakkeveettil A, Whedon J, Schmalzl L, Hurwitz EL. Yoga for Quality of Life in Individuals With Chronic Disease: A Systematic Review. Altern Ther Health Med. 2019 Jan;25(1):36-43.

Överrörlighet och kopplingen till ångest och mag-tarmbesvär

1) Csecs JLL, Iodice V, Rae CL, Brooke A, Simmons R, Quadt L, Savage GK, Dowell NG, Prowse F, Themelis K, Mathias CJ, Critchley HD, Eccles JA. Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain. Front Psychiatry. 2022 Feb 2;12:786916.

2) Patients with Ehlers-Danlos syndrome-hypermobility type (EDS-HT) have increased prevalence of gastrointestinal (GI) symptoms, particularly reflux and dyspepsia. https://pubmed.ncbi.nlm.nih.gov/27683076/

3) Sharp HEC, Critchley HD, Eccles JA. Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression. World J Psychiatry. 2021 Oct 19;11(10):805-820.

4) Pailhez G, Rosado S, Bulbena Cabré A, Bulbena A. Joint hypermobility, fears, and chocolate consumption. J Nerv Ment Dis. 2011 Nov;199(11):903-6.

5) Javadi Parvaneh V, Modaress S, Zahed G, Rahmani K, Shiari R. Prevalence of generalized joint hypermobility in children with anxiety disorders. BMC Musculoskelet Disord. 2020 Jun 2;21(1):337.

6)Do T, Diamond S, Green C, Warren M. Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes. Curr Nutr Rep. 2021 Dec;10(4):324-333.

7) Brockway L. Gastrointestinal problems in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. Ehler-Danlos Support UK. https://www.ehlers-danlos.org/information/gastrointestinal-problems-in-hypermobile-ehlers-danlos-syndrome-and-hypermobility-spectrum-disorders

8) Zhou W, Zikos T, Neshatian L, Nguyen L. S0476 high prevalence of methane predominant small bowel bacterial overgrowth and constipation in patients with hypermobile Ehlers-Danlos syndrome. Off J Am Coll Gastroenterol ACG. 2020;115:S238.

Nr 2, 2022: Lust

Sjunkande testosteronnivåer – en skrämmande trend

https://pubmed.ncbi.nlm.nih.gov/17062768/
https://pubmed.ncbi.nlm.nih.gov/32081788/
https://pubmed.ncbi.nlm.nih.gov/29774504/
https://pubmed.ncbi.nlm.nih.gov/32168194/
https://pubmed.ncbi.nlm.nih.gov/28981654/
https://www.naturskyddsforeningen.se/artiklar/10-satt-att-undvika-pfas/
https://www.ewg.org/consumer-guides

Solskydd med solkig baksida

https://www.radron.se/granskningar/omstridda-solskydd-under-luppen/

https://www.dagensmedicin.se/specialistomraden/cancer/kemiska-solskydd-kan-ga-ut-i-blodet/

Den moderna hygienen, ett rent helvete

https://www.theatlantic.com/health/archive/2016/06/i-stopped-showering-and-life-continued/486314/

Föryngring inom räckhåll – så minskar du din biologiska ålder

1. Sindi S, Solomon A, Kåreholt I, Hovatta I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Ngandu T, Kivipelto M; FINGER Study Group. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):491-498.

2. Gerontological society of America. Cellular Nutrition and Its Influence on Age-Associated Cellular Decline. Nyhetsbrev nov. 2021. https://www.geron.org/images/gsa/documents/whatshotcellularnutrition.pdf Hämtad 2022-04-29

3. Gensous N, Garagnani P, Santoro A, Giuliani C, Ostan R, Fabbri C, Milazzo M, Gentilini D, di Blasio AM, Pietruszka B, Madej D, Bialecka-Debek A, Brzozowska A, Franceschi C, Bacalini MG. One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project. Geroscience. 2020 Apr;42(2):687-701.

4. Chen L, Dong Y, Bhagatwala J, Raed A, Huang Y, Zhu H. Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):91-98.

5. Fitzgerald KN, Hodges R, Hanes D, Stack E, Cheishvili D, Szyf M, Henkel J, Twedt MW, Giannopoulou D, Herdell J, Logan S, Bradley R. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021 13(7), 9419–9432.

6. Ritchie, H. The world population is changing. Our world in data, 2019-05-23. https://ourworldindata.org/population-aged-65-outnumber-children Hämtad 2022-04-29.

7. Kirkland JL, De Rooij SE, Goldman DP. Proof-of-concept clinical trials of interventions that target fundamental aging processes how can interventions be translated from the laboratory into clinical practice the economic returns to delayed aging: promise and pitfalls. Innov Aging. 2017. (Suppl 1); 1:1082.

8. Fitzgerald K. Younger You. Quercus Publishing, 2022.

Brister eller begär – kan chokladsuget bero på näringsbrist?

1) Komatsu S. Rice and sushi cravings: a preliminary study of food craving among Japanese females. Appetite. 2008;50:353–358.

2) Romaní-Pérez M, Bullich-Vilarrubias C, López-Almela I, Liébana-García R, Olivares M, Sanz Y. The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis. Int J Mol Sci. 2021 May 29;22(11):5830.

3) Trevelline BK, Kohl KD. The gut microbiome influences host diet selection behavior. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2117537119.

4) Alcock J, Maley CC, Aktipis CA. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays. 2014 Oct;36(10):940-9.

5) Meule A. The Psychology of Food Cravings: the Role of Food Deprivation. Curr Nutr Rep. 2020 Sep;9(3):251-257.

Näringsstöd vid långtidscovid

[1]) Paul Garner: on his recovery from long covid. The BMJ Opinion. 2021-01-25. https://blogs.bmj.com/bmj/2021/01/25/paul-garner-on-his-recovery-from-long-covid/ Hämtad 2022-05-20.

2) Bland JS. The Long Haul of COVID-19 Recovery: Immune Rejuvenation versus Immune Support. Integr Med (Encinitas). 2020 Dec;19(6):18-22.

3) Benson D. Leo Galland, MD: Treating PASC (Post-Acute Sequelae of COVID): How to Address Long-Hauler’s Syndrome Effectively. Integr Med (Encinitas). 2021 Dec;20(6):36-37.

4) Cuervo AM, Macian F. Autophagy, nutrition and immunology. Mol Aspects Med. 2012. February;33(1):2-13.

5) Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X. Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. J Lipid Res. 2017. September;58(9):1808-1821.

6) Santos JC, Ribeiro ML, Gambero A. The Impact of Polyphenols-Based Diet on the Inflammatory Profile in COVID-19 Elderly and Obese Patients. Front Physiol. 2021 Jan 12;11:612268.

Nr 1, 2022: Allergi

Födoämneskänslighet, skillnaden mellan allergi, intolerans och fördröjd allergi

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

[1] Bannon GA. What makes a food protein an allergen? Curr Allergy Asthma Rep. 2004 Jan;4(1):43-6.

[1] Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40.

[1] Dieterich W, Tietz E, Kohl M, Konturek PC, Rath T, Neurath MF, Zopf Y. Food Intolerance of Unknown Origin: Caused by Mucosal Inflammation? A Pilot Study. Clin Transl Gastroenterol. 2021 Feb 17;12(2):e00312.

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

[1] Zopf Y, Baenkler HW, Silbermann A, Hahn EG, Raithel M. The differential diagnosis of food intolerance. Dtsch Arztebl Int. 2009 May;106(21):359-69; quiz 369-70; 4 p following 370.

[1] Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40.

[1] Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green PH, Verna EC, Volta U, Alaedini A. Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut. 2016 Dec;65(12):1930-1937.

[1] Uhde M, Caio G, De Giorgio R, Green PH, Volta U, Alaedini A. Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease. Gastroenterology. 2020 Jul 20:S0016-5085(20)34992-1.

[1] Dixon HS. Treatment of delayed food allergy based on specific immunoglobulin G RAST testing. Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):48-54.

[1] Kukkonen AK, Savilahti EM, Haahtela T, Savilahti E, Kuitunen M. Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders. Clin Exp Allergy. 2011 Oct;41(10):1414-21.

[1] Bentz S, Hausmann M, Piberger H, Kellermeier S, Paul S, Held L, Falk W, Obermeier F, Fried M, Schölmerich J, Rogler G. Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: a double-blind cross-over diet intervention study. Digestion. 2010;81(4):252-64.

[1] Xie Y, Zhou G, Xu Y, He B, Wang Y, Ma R, Chang Y, He D, Xu C, Xiao Z. Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome. Pain Res Manag. 2019 Aug 21;2019:7890461.

[1] Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. Headache. 2013 Mar;53(3):514-25.

[1] Guo H, Jiang T, Wang J, Chang Y, Guo H, Zhang W. The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhoea. J Int Med Res. 2012;40(1):204-10.

[1] Food allergy mediated by IgG antibodies associated with migraine in adults. Arroyave Hernandez CM, Echevarria Pinto M, Hernandez Montiel HL. Rev Alerg Mex (2007); 54: 162–168.

[1] Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Cephalalgia. 2010 Jul;30(7):829-37.

[1] Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79.

[1] Marsh JT, Jayasena S, Gaskin F, Baumert JL, Johnson P. Thermal processing of peanut impacts detection by current analytical techniques. 2020 May;313(30).

[1] Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009 Apr;39(4):469-77.

[1] Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S, Kleine-Tebbe J; EAACI Task Force. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy. 2008 Jul;63(7):793-6.

[1] NIAID 2010 Guidelines J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58.

Medscape Food Allergy: What You Need to Know 11/2010; Medscape Food Allergy:

The Definitive Guide to Clinical Practice: A Reliable Approach to Diagnosis 12/2010 010

Diffusa symtom kan vara histaminintolerans

Jutel M, Akdis M, Akdis CA. Histamine, histamine receptors and their role in immune pathology. Clin Exp

Allergy. 2009 Dec;39(12):1786-800.
Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96.
Muñoz-Cruz S, Mendoza-Rodríguez Y, Nava-Castro KE, Yepez-Mulia L, Morales-Montor J. Gender-related effects of sex steroids on histamine release and FcεRI expression in rat peritoneal mast cells. J Immunol Res. 2015;2015:351829.
Zierau O, Zenclussen AC, Jensen F. Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Front Immunol. 2012 Jun 19;3:169.
Vasiadi M, Kempuraj D, Boucher W, Kalogeromitros D, Theoharides TC. Progesterone inhibits mast cell secretion. Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):787-94.
Bódis J, Tinneberg HR, Schwarz H, Papenfuss F, Török A, Hanf V. The effect of histamine on progesterone and estradiol secretion of human granulosa cells in serum-free culture. Gynecol Endocrinol. 1993 Dec;7(4):235-9.
Maintz L, Schwarzer V, Bieber T, van der Ven K, Novak N. Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Hum Reprod Update. 2008 Sep-Oct;14(5):485-95.
Ulf Bengtsson och Nils E Eriksson (red) Förrädisk föda. Andra reviderade upplagan, Astra Zeneca 2003

https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf

”En allergiepidemi” Är hygienhypotesen förklaringen?

Prescott SL, et al. A global survey of changing patterns of food allergy burden in children. World Allergy Organ J. 2013;6(1):21.

Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. 2017 Sep 19;18(10):1076-1083. doi: 10.1038/ni.3829. PMID: 28926539.
Romano-Keeler J, Weitkamp JH. Maternal influences on fetal microbial colonization and immune development. Pediatr Res. 2015 Jan;77(1-2):189-95. doi: 10.1038/pr.2014.163. Epub 2014 Oct 13. PMID: 25310759; PMCID: PMC4289016.
Ipci K, Altıntoprak N, Muluk NB, Senturk M, Cingi C. The possible mechanisms of the human microbiome in allergic diseases. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):617-626. doi: 10.1007/s00405-016-4058-6. Epub 2016 Apr 26. PMID: 27115907.
Lee-Sarwar K. The farm-like effect: Rural exposures in early life, the microbiome, and asthma. J Allergy Clin Immunol. 2021 Jul;148(1):89-90. doi: 10.1016/j.jaci.2021.04.020. Epub 2021 Apr 26. PMID: 33915125.
Fleming JO, Weinstock JV. Clinical trials of helminth therapy in autoimmune diseases: rationale and findings. Parasite Immunol. 2015 Jun;37(6):277-92. doi: 10.1111/pim.12175. PMID: 25600983.
Clavel T, Gomes-Neto JC, Lagkouvardos I, Ramer-Tait AE. Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes. Immunol Rev. 2017 Sep;279(1):8-22. doi: 10.1111/imr.12578. PMID: 28856739; PMCID: PMC5657458.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014 Feb;20(2):159-66. doi: 10.1038/nm.3444. Epub 2014 Jan 5. PMID: 24390308.
Fallon, P., Mangan, N. Suppression of TH2-type allergic reactions by helminth infection. Nat Rev Immunol 7, 220–230 (2007).
Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days – intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol. 2014 Aug;25(5):428-38. doi: 10.1111/pai.12232. Epub 2014 Jun 5. PMID: 24899389.

Kan allergier hos barn förebyggas?

Internetmedicin.se Födoämnesöverkänslighet. Tillgänglig på: https://www.internetmedicin.se/behandlingsoversikter/allergologi/fodoamnesoverkanslighet/ Hämtad 2022-02-22.

Institutet för miljömedicin: BAMSE-projektet. Karolinska institutet. Tillgänglig på: https://ki.se/imm/bamse-projektet Hämtad 2022-02-22.
Haahtela T. A biodiversity hypothesis. Allergy. 2019 Aug;74(8):1445-1456.
Karolinska institutet. Medicinvetarna #64: Kan allergi botas? Poddsändning. Tillgänglig på: https://ki.se/forskning/medicinvetarna-64-kan-allergi-botas Hämtad 2022-02-22.
Sdona E, Hallberg J, Andersson N, et al. Dietary antioxidant intake in school age and lung function development up to adolescence. Eur Respir J. 2020;55(2):1900990.
Magnusson J, Kull I, Rosenlund H, Håkansson N, Wolk A, Melén E, Wickman M, Bergström A. Fish consumption in infancy and development of allergic disease up to age 12 y. Am J Clin Nutr. 2013 Jun;97(6):1324-30.
Magnusson J, Kull I, Westman M, Håkansson N, Wolk A, Melén E, Wickman M, Bergström A. Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis. J Allergy Clin Immunol. 2015 Nov;136(5):1247-53.e1-2.
Vickery BP, Vereda A, Nilsson C, du Toit G, Shreffler WG, Burks AW, Jones SM, Fernández-Rivas M, Blümchen K, O’B Hourihane J, Beyer K, Smith A, Ryan R, Adelman DC. Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study. J Allergy Clin Immunol Pract. 2021 May;9(5):1879-1889.e14.

Nr 4, 2021: Trötthet

Lustmördar gamla folkhälsosanningar med glädje, evidens och humor

[1] Toledo E, Salas-Salvadó J, Donat-Vargas C, Buil-Cosiales P, Estruch R, Ros E, Corella D, Fitó M, Hu FB, Arós F, Gómez-Gracia E, Romaguera D, Ortega-Calvo M, Serra-Majem L, Pintó X, Schröder H, Basora J, Sorlí JV, Bulló M, Serra-Mir M, Martínez-González MA. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med. 2015 Nov;175(11):1752-1760.

Kardiologen som vägrar sockra sanningen

[1] Mayo Clinic. Mediterranean diet for heart health. Bloggartikel, 2021-07-23.

https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801

[2] Diamond DM, Alabdulgader AA, de Lorgeril M, Harcombe Z, Kendrick M, Malhotra A, O’Neill B, Ravnskov U, Sultan S, Volek JS. Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone. BMJ Evid Based Med. 2020 Jul 5:bmjebm-2020-111412.

[3] Ebbeling CB, Knapp A, Johnson A, Wong JMW, Greco KF, Ma C, Mora S, Ludwig DS. Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia-a randomized controlled feeding trial. Am J Clin Nutr. 2021 Sep 28:nqab287.

Varför är jag så trött?

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):181-90

Dignar du under kognitiv belastning? Zoomtrötthet nytt forskningsämne

1) Fauville G et al. Nonverbal Mechanisms Predict Zoom Fatigue and Explain Why Women Experience Higher Levels than Men. Göteborgs universitet, 2021.

2) Bailenson JN. Nonverbal Overload: A Theoretical Argument for the Causes of Zoom Fatigue, Jeremy Bailenson, Stanford University. Technology, Mind and Behavior 2021;2(1).

3) Four reasons you’re tired of Zoom calls — and what to do about it. Washington Post 3 mars 2021. https://www.washingtonpost.com/lifestyle/2021/03/03/stanford-zoom-fatigue/

4) Global Gender Gap Report 2021, World Economic Forum, www.weforum.org.

5) Hallman DM, Januario LB, Mathiassen SE, Heiden M, Svensson S, Bergström G. Working from home during the COVID-19 outbreak in Sweden: effects on 24-h time-use in office workers. BMC Public Health. 2021 Mar 17;21(1):528.

Siesta bra för hjärtat – men tuppluren är lurig

1.Poulimenos L, Kallistratos M, Tsinivizov P, Kouremenos N, Kontogiannis N et al. Mid-day Sleep Effects as Potent as Recommended Lifestyle Changes in Patients With Arterial Hypertension. J Am Coll Cardiol. 2019 Mar, 73 (9_Supplement_2) 20

2. KecklundG, Ingre M, Åkerstedt T. Arbetstider, hälsa och säkerhet – en uppdatering av aktuell forskning. Stressforskningsrapport nr 322, Stressforskningsinstitutet, Stockholms universitet 2010.

3. Stepan ME, Altmann EM, Fenn KM. Slow Wave Sleep During a Brief Nap is Related to Reduced Cognitive Deficits During Sleep Deprivation. Sleep. 2021 Jun 22:zsab152.

4. Din hjärna, säsong två: Din sömn. Programserie av Anders Hansen, svtplay.se.

Näringen du behöver för att bilda energi

1) Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020 Jan 16;12(1):228. 2) Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements? Int J Sport Nutr Exerc Metab. 2006 Oct;16(5):453-84.

3) Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658.

Snabb diagnos är A och O vid ME/CFS

Källa: www.viss.nu

Kaffe: Hälsoboost eller hälsobov?

Brice CF, Smith AP. Effects of caffeine on mood and performance: a study of realistic consumption. Psychopharmacology (Berl). 2002 Nov;164(2):188-92.

Doherty M, Smith PM. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46.
Lara B, Ruiz-Moreno C, Salinero JJ, Del Coso J. Time course of tolerance to the performance benefits of caffeine. PLoS One. 2019 Jan 23;14(1):e0210275.
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Nerurkar PV, Gandhi K, Chen JJ. Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006. Nutrients. 2021;13(4):1348.
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Nr 3, 2021: Virusinfektioner

Arvet från aporna: en mutation kan vara orsaken till fetmaepidemin

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Näringsämnen som skyddar oss mot virus

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Nr 2, 2021: Sömn

Drömmen om en bättre sömn

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Kopplingen mellan sömnbrist och inflammation

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Så städas din hjärna när du sover

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Melatonin – mer än bara sömnhormon

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Nr 1, 2021: Psykisk ohälsa

Väck kraften i din vagusnerv

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Psykiatri med nytt perspektiv

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Läckande tarm – kopplingen mellan inflammation och depression

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Kostvanor och mental hälsa – vilka är sambanden?

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15Kennedy, David O. ”B vitamins and the brain: mechanisms, dose and efficacy—a review.” Nutrients 8.2 (2016): 68.

16 Burkert, Nathalie T., et al. ”Nutrition and health–the association between eating behavior and various health parameters: a matched sample study.” PloS one 9.2 (2014): e88278.

17 Sinn, Natalie, et al. ”Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial.” British Journal of Nutrition 107.11 (2012): 1682-1693.

18Kočovská, Eva, et al. ”Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism.” Frontiers in psychiatry 8 (2017): 47.

19Markova, Veronika, et al. ”Impairment of the developing human brain in iron deficiency: correlations to findings in experimental animals and prospects for early intervention therapy.” Pharmaceuticals 12.3 (2019): 120.

20 Chen, Mu-Hong, et al. ”Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study.” BMC psychiatry 13.1 (2013): 161.

21 Piao, Meihua, et al. ”The role of zinc in mood disorders.” Neuropsychiatry 7.4 (2017): 378-386.

Litium som skydd för hjärnan

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[2] Schrauzer GN, de Vroey E. Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users. Biol Trace Elem Res. 1994 Jan;40(1):89-101.

[3] Schrauzer GN, de Vroey E. Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users. Biol Trace Elem Res. 1994 Jan;40(1):89-101.

[4] Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M. Low-dose lithium uptake promotes longevity in humans and metazoans. Eur J Nutr. 2011 Aug;50(5):387-9.

[5] Memon A, Rogers I, Fitzsimmons SMDD, Carter B, Strawbridge R, Hidalgo-Mazzei D, Young AH. Association between naturally occurring lithium in drinking water and suicide rates: systematic review and meta-analysis of ecological studies. Br J Psychiatry. 2020 Jul 27:1-12.

[6] Del Matto L, Muscas M, Murru A, Verdolini N, Anmella G, Fico G, Corponi F, Carvalho AF, Samalin L, Carpiniello B, Fagiolini A, Vieta E, Pacchiarotti I. Lithium and suicide prevention in mood disorders and in the general population: A systematic review. Neurosci Biobehav Rev. 2020 Sep;116:142-153.

[7] Barjasteh-Askari F, Davoudi M, Amini H, Ghorbani M, Yaseri M, Yunesian M, Mahvi AH, Lester D. Relationship between suicide mortality and lithium in drinking water: A systematic review and meta-analysis. J Affect Disord. 2020 Mar 1;264:234-241.

[8] Greenblatt J. Lithium: The Untold Story Of The Magic Mineral That Charges Cell Phones And Preserves Memory. Integrative medicine for mental health 2017. http://www.immh.org/article-source/2017/2/2/lithium-the-untold-story-of-the-magic-mineral-that-charges-cell-phones-and-preserves-memory

[9] Ann-Louise Gittleman. The Cinderella mineral that could defeat Alzheimer’s. Juni 2020.

[10] Choi YJ, Yoon Y, Lee KY, Kang YP, Lim DK, Kwon SW, Kang KW, Lee SM, Lee BH. Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. Toxicol Sci. 2015 Apr;144(2):307-17.

[11] Han X, Liu C, Xue Y, Wang J, Xue C, Yanagita T, Gao X, Wang Y. Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats. Biosci Biotechnol Biochem. 2016;80(4):735-43.

[12] Ann-Louise Gittleman. The Cinderella mineral that could defeat Alzheimer’s. Juni 2020.

[13] Moore GJ, et al. Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1,241-1,242.

[14] Sun YR, Herrmann N, Scott CJM, Black SE, Khan MM, Lanctôt KL. Global grey matter volume in adult bipolar patients with and without lithium treatment: A meta-analysis. J Affect Disord. 2018 Jan 1;225:599-606.

[15] Loria K. Psychiatrist: Maybe, Just Maybe, Everyone Should Take Lithium.

https://www.businessinsider.com/is-lithium-good-for-you-2014-12?r=US&IR=T

[16] Shao L, Cui J, Young LT, Wang JF. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience. 2008 Jan 24;151(2):518-24.

[17] Greenblatt J. Low Dose Lithium For The Treatment Of Mood, Behavioral, And Cognitive Disorders. Föredrag 2016. https://www.greatplainslaboratory.com/webinars/2016/4/13/low-dose-lithium-for-the-treatment-of-mood-behavioral-and-cognitive-disorders

[18] Greenblatt J. Lithium: The mineral as medicine. Blogginlägg 2020-07-12. https://www.lowdoselithium.com/blog/2020/7/12/a-nobel-winning-technology-reaffirms-a-noble-nutritional

[19] Statens geologiska institut. ”Litium.” 2020-10-06. https://sgu.se/mineralnaring/kritiska-ravaror/litium/

[20] Shorter E. The history of lithium therapy. Bipolar Disord. 2009 Jun;11 Suppl 2(Suppl 2):4-9.

Dopamin – drivkraft, livslust och meningsfullhet

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Så mäter du intolerans mot födoämnen

1. Muraro A, Halken S, Arshad SH, et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy 2014;69:590-601.

2. Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014;69:1008-25.

3. Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol 2012;8:12.

4. Johansson SG, Dannaeus A, Lilja G. The relevance of anti-food antibodies for the diagnosis of food allergy. Ann Allergy 1984;53(6 Pt 2):665-72.

5. Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008;100(3 Suppl 3):S1-148.

6. Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol 2012;8:12.

7. Bock SA. AAAAI support of the EAACI Position Paper on IgG4. J Allergy Clin Immunol 2010;125:1410.

8. Ruiter B, Knol EF, van Neerven RJ, Garssen J, Bruijnzeel-Koomen CA, Knulst AC, van Hoffen E. Maintenance of tolerance to cow’s milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. Clin Exp Allergy. 2007 Jul;37(7):1103-10.

9. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292–300

10. Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016 Nov-Dec;36(6):386-390.

11. Karakula-Juchnowicz H, Gałęcka M, Rog J, et al. The Food-Specific Serum IgG Reactivity in Major Depressive Disorder Patients, Irritable Bowel Syndrome Patients and Healthy Controls. Nutrients. 2018;10(5):548. Published 2018 Apr 28.

12. Wang HY, Li Y, Li JJ, et al. Serological investigation of IgG and IgE antibodies against food antigens in patients with inflammatory bowel disease. World J Clin Cases. 2019;7(16):2189-2203.

13. Fedor I, Zold E, Barta Z. Food-specific IgG Antibodies in Crohn’s Disease: What Came First, the Chicken or the Egg? Intern Med. 2019 Jul 15;58(14):2123.

14. Jian L, Anqi H, Gang L, Litian W, Yanyan X, Mengdi W, Tong L. Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study. Inflamm Bowel Dis. 2018 Aug 16;24(9):1918-1925.

15. Mitchell N, Hewitt CE, Jayakody S, Islam M, Adamson J, Watt I, Torgerson DJ. Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Nutr J. 2011 Aug 11;10:85.

16. Aucoin M, Bhardwaj S. Major Depressive Disorder and Food Hypersensitivity: A Case Report. Neuropsychobiology. 2019;78(4):249-255.

17. Geiselman JF. The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review. Curr Pain Headache Rep. 2019 Aug 27;23(11):79.

18. Lin S, Yang X, Xing Y, Wang X, Li Y. The Clinical Application Value of Multiple Combination Food Intolerance Testing. Iran J Public Health. 2019 Jun;48(6):1068-1073.

19. Veloso-Teles R, Cerejeira R, Rodrigues D, Roque-Farinha R, von Buchwald C. Food-Specific IgE and IgG Antibodies in Patients With Chronic Rhinosinusitis With Nasal Polyps: A Case-Control Study. Ear Nose Throat J. 2021 Mar;100(3):177-184.

20. Kaličanin D, Brčić L, Barić A, Zlodre S, Barbalić M, Torlak Lovrić V, Punda A, Boraska Perica V. Evaluation of Correlations Between Food-Specific Antibodies and Clinical Aspects of Hashimoto’s Thyroiditis. J Am Coll Nutr. 2019 Mar-Apr;38(3):259-266.

Nr 6, 2020: Cancer

Så mäter du din kondition

Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study.Eur Heart J. 2004; 25:1428–1437.
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Hur går det till när C-vitamin dödar cancerceller?

[1] Lim JY, Kim D, Kim BR, Jun JS, Yeom JS, Park JS, Seo JH, Park CH, Woo HO, Youn HS, Baik SC, Lee WK, Cho MJ, Rhee KH. Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondria. Oncol Lett. 2016 Nov;12(5):4270-4276.

[2] Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR. Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biol. 2016 Dec;10:274-284.

[3] Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414.

[4] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9.

[5] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42.

[6] Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs. 2012 Apr;23(4):437-44.

[7] Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Dec 11;350(6266):1391-6.

[8] Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M. Intravenously administered vitamin C as cancer therapy: three cases. CMAJ. 2006 Mar 28;174(7):937-42.

[9] Taxman ET, Conlon ED, Speers A, Dismuke KL, Heyman TS, Taxman TL. Chemotherapy and Functional Medicine in a Patient With Metastatic Breast Cancer: A Case Report. Integr Med (Encinitas). 2016 Mar;15(1):27-32.

[10] Mikirova N, Hunnunghake R, Scimeca RC, Chinshaw C, Ali F, Brannon C, Riordan N. High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report. Am J Case Rep. 2016 Oct 24;17:774-781.

[11] Carr AC, Cook J. Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge. Front Physiol. 2018 Aug 23;9:1182.

[12] Thompson D. Intravenous Vitamin C May Boost Chemo’s Cancer-Fighting Power. HealthDay, 2014-02-05.

[13] Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9.

[14] Lorenzato A, Magri A, Matafora V. Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer. Cancers (Basel). 2020 Mar 14;12(3):685.

[15] Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, et al. O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 2017 Apr 10;31(4):487-500.e8.

[16] Magri A, Germano G, Lorenzato A, Lamba S, Chilà R, et al. High-dose vitamin C enhances cancer immunotherapy. Sci Transl Med. 2020 Feb 26;12(532):eaay8707.

[17] Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R et al. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 May 11;11(1):2332.

[18] Vårdguiden. ”Vad är G6PD?” https://www.1177.se/Stockholm/fragor–svar/nationellt/sjukdomar–besvar/vad-ar-g6pd/ Hämtad 20-11-18.

Kan antioxidanter öka risken för cancer?

[1] Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. Sci Transl Med. 2015 Oct 7;7(308):308re8.

[2] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

[3] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

Mutationsteorins utmanare: ”Cancer kan inte leva utan glutamin och glukos”

[i] İyikesici MS, Slocum AK, Slocum A, Berkarda FB, Kalamian M, Seyfried TN. Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer. Cureus. 2017 Jul 7;9(7):e1445.

[ii] https://www.facebook.com/pablosbrainjourney/

[iii] Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar 11;12:12.

[iv] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

[v] Augur ZM, Doyle CM, Li M, Mukherjee P, Seyfried TN. Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma. Front Nutr. 2018 Oct 5;5:91.

[vi] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

[vii] https://www.facebook.com/pablosbrainjourney/posts/1955319981383663

[viii] Poff AM, Ari C, Seyfried TN, D’Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One. 2013 Jun 5;8(6):e65522.

[ix] İyikesici MS. Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. Int J Hyperthermia. 2019;36(1):446-455.

[x] Pawelek JM. Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer. Chin J Cancer. 2014 Mar;33(3):133-9. doi: 10.5732/cjc.013.10243. PMID: 24589183; PMCID: PMC3966146.

[xi] Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res. 2012 Jan 15;18(2):370-9.

[xii] Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature. 2009 Apr 9;458(7239):719-24.

[xiii] Soto AM, Sonnenschein C. The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays. 2004 Oct;26(10):1097-107.

[xiv] Aguilera O, Muñoz-Sagastibelza M, Torrejón B, Borrero-Palacios A, Del Puerto-Nevado L, Martínez-Useros J, Rodriguez-Remirez M, Zazo S, García E, Fraga M, Rojo F, García-Foncillas J. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget. 2016 Jul 26;7(30):47954-47965.

Cancer och immunterapi

1. Douglas Hanahan, Robert A. Weinberg. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.

2. Maria V. Liberti, Jason W. Locasale. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016;41(3):211-218.

3.Dominique C. Hinshaw, Lalita A. Shevde. The Tumor Microenvironment Innately Modulates Cancer Progression.

4. Grens K. Cancer Immunotherapy Trial Suspended After Deaths. The Scientist, 2016-07-08.

5. Söderlund Leifler K.Immunsystemet får hjälp att bekämpa cancer. Forskning & framsteg. 2014-06-08

6. John Hopkins Medicine. Side effects of immunotherapy: what to look for and when? Blogginlägg 2016-06-23.

7. John Hopkins Medicine. New Cancer Immunotherapy Drugs Linked To Arthritis in Some Patients. Pressmeddelande 2016-06-23.

8.https://www.pnas.org/content/early/2020/11/20/2015343117

9. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

10. Cancerfonden. Kroppens eget försvar väcker hopp om bot. Blogginlägg 2014-05-28.

11. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

12. Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004 Jun;9(2):180-97. PMID: 15253677.

13. Bastyr University. Probiotics and the Immune System. Blogginlägg 2010-11-08.

14. Kitamura M.How Gut Bacteria Are Shaking Up Cancer Research. Bloomberg 2016-03-14

15. UChicago News. Gut bacteria can dramatically amplify cancer immunotherapy. Pressmeddelande 2015-11-06.

16. Vétizou M, Pitt JM, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 27;350(6264):1079-84.

17. Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi, Amirhossein Sahebkar. Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacol Res. 2017;117:218-227.

18. Dona Sinha, Nivedita Sarkar, Jaydip Biswas, Anupam Bishayee. Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Semin Cancer Biol. 2016;40-41:209-232.

19. Lindsay G. Carter, John A. D’Orazio, Kevin J. Pearson. Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer. 2014;21(3):R209-R225.

Lästips:

Cancer: The Journey from Diagnosis to Empowerment, av Anderson, Paul.

A. Radical Remission: Surviving Cancer Against All Odds, av Turner, Kelly
Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer, av Stengler, Mark, Anderson, Paul.
The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies, av Winters, Nasha, Higgins Kelley, Jess, Turner, Jess,
Vital Strategies in Cancer, av Roach, Jim.

Tränar du? Du kan ändå röra dig farligt lite

Folkhälsomyndigheten
Saint-Maurice PF, Troiano RP, Bassett DR Jr, Graubard BI, Carlson SA, Shiroma EJ, Fulton JE, Matthews CE. Association of Daily Step Count and Step Intensity With Mortality Among US Adults.JAMA. 2020 Mar 24;323(12):1151-1160.
Physiology of Sport and Exercise Sixth Edition W. Larry Kenney et al
Rundqvist H, Veliça P, Barbieri L, Gameiro PA, Bargiela D, Gojkovic M, Mijwel S, Reitzner SM, Wulliman D, Ahlstedt E, Ule J, Östman A, Johnson RS. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. Elife. 2020 Oct 23;9:e59996.

Metabol ohälsa kan förvärra covid-19

de Menezes, Ehrika Vanessa Almeida, et al. ”Influence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysis.” Nutrition journal 18.1 (2019): 41.

Yancy, William S., et al. ”A low-carbohydrate, ketogenic diet to treat type 2 diabetes.” Nutrition & metabolism 2.1 (2005): 34.
Masharani, Umesh, et al. ”Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.” European journal of clinical nutrition 69.8 (2015): 944-948.
Jönsson, Tommy, et al. ”Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study.” Cardiovascular diabetology 8.1 (2009): 35.
Fontes-Villalba, Maelán, et al. ”Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial.” Cardiovascular Diabetology 15.1 (2016): 80.
Frassetto, Lynda A., et al. ”Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic–Hunter–Gatherer-type diets.” European journal of clinical nutrition 67.9 (2013): 899-903.
Jönsson, Tommy, et al. ”Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes.” Nutrition journal 12.1 (2013): 105.
Al-Saady, N. M., C. M. Blackmore, and E. D. Bennett. ”High fat, low carbohydrate, enteral feeding lowers PaCO 2 and reduces the period of ventilation in artificially ventilated patients.” Intensive care medicine 15.5 (1989): 290-295.
Lakka, Timo A., and David E. Laaksonen. ”Physical activity in prevention and treatment of the metabolic syndrome.” Applied physiology, nutrition, and metabolism 32.1 (2007): 76-88.

Kallbad som medicin

Huttunen, Pirkko, Leena Kokko, and Virpi Ylijukuri. ”Winter swimming improves general well-being.” International Journal of Circumpolar Health 63.2 (2004): 140-144.
Hirvonen, Jorma, et al. ”Plasma catecholamines, serotonin and their metabolites and beta-endorphin of winter swimmers during one winter. Possible correlations to psychological traits.” International journal of circumpolar health 61.4 (2002): 363-372.
Lindeman, Sari, Jorma Hirvonen, and Matti Joukamaa. ”Neurotic psychopathology and alexithymia among winter swimmers and controls-a prospective study.” International journal of circumpolar health 61.2 (2002): 123-130.
Peake, Jonathan M., et al. ”The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise.” The Journal of physiology 595.3 (2017): 695-711.
Siems, W. G., et al. ”Improved antioxidative protection in winter swimmers.” Qjm 92.4 (1999):
Mooventhan, A., and L. Nivethitha. ”Scientific evidence-based effects of hydrotherapy on various systems of the body.” North American journal of medical sciences 6.5 (2014): 199.

Nr 5, 2020: Karnivorkost

Regenerativt jordbruk för hållbar hälsa och bättre miljö

Lancaster University. Global study reveals time running out for many soils – but conservation measures can help. Pressmeddelande 2020-09-14.
Willett W, Rockström J, Loken B, et al. Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems [published correction appears in Lancet. 2019 Feb 9;393(10171):530] [published correction appears in Lancet. 2019 Jun 29;393(10191):2590] [published correction appears in Lancet. 2020 Feb 1;395(10221):338]. Lancet. 2019;393(10170):447-492.
Cornell S, Crona B, Jonell M m.fl. Ställ om snabbt till nyttigare och mer klimatsmart mat. Debattartikel, DN 2017-01-18.
Edman S, Gardfjell M, Granstedt A m.fl. En global diet skulle leda till katastrof. Replik på debattartikel, DN 2017-01-18.
LaCanne CE, Lundgren JG. Regenerative agriculture: merging farming and natural resource conservation profitably. PeerJ. 2018 Feb 26;6:e4428.

Djuruppfödning – ett mynt med två sidor

https://www.swissinfo.ch/eng/factory-farming_swiss-government-gives-animal-welfare-a-boost/45525498
samt konversation med Schweiz ambassad som bekräftat påståendena i texten.
Danska kycklingproducenter: Tidningen Syre
https://tidningensyre.se/2020/20-april/dansk-jatte-fasar-ut-turbokycklingar/
Pandemi och kött, professor Björn Olsen som skrivit boken Pandemi:
https://www.aftonbladet.se/nyheter/a/P9A1db/professorn-inga-pandemier-om-alla-hade-varit-vegetarianer

Karnivorkostens historia

Harrison, Adrian, and Else Marie Bartels. ”A Comparison of Ancient Greek and Roman Sports Diets with Modern Day Practices.” Sports Nutrition and Therapy 1.1 (2016).
Lieb, Clarence W. ”The effects of an exclusive, long-continued meat diet: Based on the history, experiences and clinical survey of Vilhjalmur Stefansson, Arctic explorer.” Journal of the American Medical Association 87.1 (1926): 25-26.
Cordain, Loren, et al. ”Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets.” The American journal of clinical nutrition 71.3 (2000): 682-692.

Vanliga besvär vid omställning till karnivorkost

Harvey, Cliff JdC, et al. ”Effects of differing levels of carbohydrate restriction on the achievement of nutritional ketosis, mood, and symptoms of carbohydrate withdrawal in healthy adults: A randomized clinical trial.” Nutrition: X (2019): 100005.
Hernandez, Teri L., et al. ”Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet.” The American journal of clinical nutrition 91.3 (2010): 578-585.
Hernandez, Teri L., et al. ”Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet.” The American journal of clinical nutrition 91.3 (2010): 578-585.
Tiwari, Swasti, Shahla Riazi, and Carolyn A. Ecelbarger. ”Insulin’s impact on renal sodium transport and blood pressure in health, obesity, and diabetes.” American Journal of Physiology-Renal Physiology 293.4 (2007): F974-F984.
Kelley, David E., and Bret H. Goodpaster. ”Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance.” Clinical Diabetology 2.4 (2001): 255-266.

Därför kan uteslutningsdieter vara symtomlindrande

Maria J.E. Visser, Douglas B. Kell, Etheresia Pretorious. Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris. Front Cell Infect Microbiol. 2019; 9:7.
Mariusz Sikora, Albert Stec, Magdalena Chrabaszcz, Aleksandra Knot, Anna Waskiel-Burnat, Adriana Rakowska, Malgorzata Olszewska, Lidia Rudnicka. Gut Microbiome in Psoriasis: An Updated Review. Pathogens. 2020;9(6):463.
Jose U Scher, Andrew Sczesnak, Randy L Longman, Nicola Segata, Carles Ubeda, Craig Bielski, Tim Rostron, Vincenzo Cerundolo, Eric G Palmer, Steven B Abramson, Curtis Huttenchower, Dan R Littman. Expansion of intenstinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013;2:e01202.
A Ebringer. The relationship between Klebsiella infection and akylosing spondylitis. Baillieres Clin Rheumatol. 1989;3(2):321-38.
Yvonne J. Huang, Homer A. Boushey. The Microbiome in Asthma. J Allergy Clin Immunol. 2015;135(1):25-30.
Taha Rashid, Clyde Wilson, Alan Ebringer. The link between ankylosing spondylitis, Chron’s disease, Klebsiella, and starch consumption. Clin Dev Immunol. 2013:872632.

“Inälvsmat är superfood” – intervju med Paul Saladino

Så mäter du bäst ditt kroppsfett

Rocha R, Cotrim HP, Carvalho FM, Siqueira AC, Braga H, Freitas LA. Body mass index and waist circumference in non-alcoholic fatty liver disease. J Hum Nutr Diet. 2005;18:365–370.
Eguchi Y, Eguchi T, Mizuta T, Ide Y, Yasutake T, Iwakiri R, Hisatomi A, Ozaki I, Yamamoto K, Kitajima Y et al. Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. J Gastroenterol. 2006;41:462–469.
van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, London R, Peduto T, Chisholm DJ, George J. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008;48:449–457.
Almeida NS, Rocha R, Cotrim HP, Daltro C. Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review. World J Hepatol 2018; 10(10): 695-701.

Nr 4, 2020: Klimakteriet

Glutation stoppade svåra andningsbesvär hos två coronasmittade patienter

1) Klein, Melissa. ”New York mom with coronavirus saved by medical-student son’s quick thinking.” New York Post, 2020-05-09.

2) Horowitz RI, Freeman PR, Bruzzese J. Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases. Respir Med Case Rep. 2020 Apr 21:101063.

3) Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 May 28;acsinfecdis.0c00288.

4) Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia (Review). The Cochrane Library 2013, Issue 8.

5) Lenton KJ, Sané AT, Therriault H, et al. Vitamin C Augments Lymphocyte Glutathione in Subjects With Ascorbate Deficiency. Am J Clin Nutr. 2003 Jan;77(1):189-95.

6) Waly MI, Al-Attabi Z, Guizani N. Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults. Prev Nutr Food Sci. 2015 Sep; 20(3): 198–203.

7) Montecinos V, Guzmán P, Barra V et al. Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione. The Journal of Biological Chemistry 282, 15506-15515.

Klimakteriebesvär – ett modernt problem?

Mellby MK, Lock M, Kaufert P. Culture and symptom reporting at menopause. Human Reprod Update. 2005;11(5):495-512.
Hunter M, Rendall M. Bio-psycho-socio-cultural perspectives on menopause. Best Pract Res Clin Obstet Gynaecol. 2007;21(2):261-74.
Henryk Dancygier. Hepatic Biotransformation. Clinical Hepatology. 127-130.
Schutz K, Carle R, Schieber A. Taraxacum—a review on its phytochemical and pharmacological profile. J Ethnopharmacol. 2006;107(3):313-23.
Hassan Malekinejad, Aysa Rezabakhsh. Hormones in Dairy Foods and Their Impact on Public Health – A Narrative Review Article. Iran J Public Health. 2015;44(6):742-758.
A.C. Gore, V.A. Chapell, S.E. Fenton, J.A. Flaws, A. Nadal, G.S. Prins, J. Toppari, R.T. Zoeller. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1-E150.
Mangala Bhaskar Murthy, Bhaskar K. Murthy. Thyroid disruptors and their possible clinical implications. Indian J Pharmacol. 2012;44(4):542-543.
https://www.ewg.org/consumer-guides
Dobrek L. The outline of stress pathophysiology and pharmacodynamic action of plant-based eustressors – adaptogens. Pol Merkur Lekalski. 2019;46(273):103-108.
Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-62.
Hoang Viet Bach, Jeongseon Kim, Seung-Kwon Myung, Young Ae Cho. Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis. J Korean Med Sci. 2016;31(12):1879-1886.
Gustavo F. Gonzales. Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. Evid Based Complement Alternativ Med. 2012; 2012: 193496.

Hormonersättning kan förebygga sjukdomar och förlänga livet

Bitner D, Brightman R, Graham S, et al. E2/P4 capsules effectively treat vasomotor symptoms irrespective of age and BMI. Poster presented at: North American Menopause Society Annual Meeting; September 25-28, 2019; Chicago, IL.https://www.menopause.org/docs/default-source/agm/poster-session-abstracts.pdf
Baber RJ, Panay N, Fenton A, the IMS Writing Group. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy, Climacteric, 19:2, 109-150 https://www.imsociety.org/manage/images/pdf/4429e3dd302aac259ad68c3be7f60599.pdf

Viktökning i klimakteriet ”Hjälp, vad är det som händer?”

1. Lizcano F, Guzmán G. Estrogen Deficiency and the Origin of Obesity during Menopause. Biomed Res Int. 2014;2014:757461. doi: 10.1155/2014/757461. Epub 2014 Mar 6.

2. Shimokata H1, Kuzuya F. Aging, basal metabolic rate, and nutrition. Nihon Ronen Igakkai Zasshi. 1993 Jul;30(7):572-6. https://www.ncbi.nlm.nih.gov/pubmed/8361073

Omdebatterat piller fyller 60 år – vad alla kvinnor borde veta om p-piller

Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø. Contemporary Hormonal Contraception and the Risk of Breast Cancer. N Engl J Med. 2017;377(23):2228‐2239.
Skovlund CW, Mørch LS, Kessing LV, Lidegaard Ø. Association of Hormonal Contraception With Depression [published correction appears in JAMA Psychiatry. 2017 Jul 1;74(7):764]. JAMA Psychiatry. 2016;73(11):1154‐1162. (kommentar: Denna är omtalad och nämns bland annat här: https://www.health.harvard.edu/blog/can-hormonal-birth-control-trigger-depression-2016101710514)
Shufelt CL, Bairey Merz CN. Contraceptive hormone use and cardiovascular disease [published correction appears in J Am Coll Cardiol. 2009 Mar 10;53(10):904]. J Am Coll Cardiol. 2009;53(3):221‐231. doi:10.1016/j.jacc.2008.09.042
Zethraeus N, Dreber A, Ranehill E, et al. A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2017;107(5):1238‐1245.
Geiger AM, Foxman B. Risk factors for vulvovaginal candidiasis: a case-control study among university students. Epidemiology. 1996;7(2):182‐187.
Guo Y, Qi Y, Yang X, et al. Association between Polycystic Ovary Syndrome and Gut Microbiota. PLoS One. 2016;11(4):e0153196. Published 2016 Apr 19.
Leonardi M, Hicks C, El-Assaad F, El-Omar E, Condous G. Endometriosis and the microbiome: a systematic review. BJOG. 2020;127(2):239‐249.

Haydeh Bolouri: ”Det går att förebygga och vända alzheimer”

1. Bolouri H., Hajimirsadeghi A. A Holistic Approach and Successful Treatment of Chronic Wound in Diabetes Mellitus by Platelet-Rich Plasma (PRP) Combined with Optimized Diet. Dermatology Case Reports, 2017,2:3.

2. Kivipelto M, Solomon A, Ahtiluoto S et al. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study Design and Progress. Alzheimers Dement. 2013 Nov;9(6):657-65

3. Kennedy M. Varannan blir sjuk av vanliga läkemedel. GöteborgsPosten, 2014-06-16.

Bredesen qDE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging (Albany NY). 2016; 8:1250-1258.

Livsstilsbehandling mot tidig alzheimer

1) Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging 2016 Jun;8(6):1250-8.

2) Bredesen D.E., Sharlin K., Jenkins D. m.fl. Reversal of Cognitive Decline: 100 Patients. Alzheimers Dis Parkinsonism. 2019; 8(5).

Nr 3, 2020: Migrän

Hjälper intravenöst C-vitamin mot Coronaviruset? av Lina Åhlén, hälsoskribent

Chen N., Zhou M., Dong X. et.al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395:10223. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30211-7/fulltext
Wald E.L., Sanchez-Pinto N., Smith C.M. et.al. Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock. ATS Journals. 2020;January
Fowler A.A., Truwit J.D., Duncan Hite R. et.al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA. 2019:322;13
Fujii T., Luethi N., Young P.J. et.al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock. JAMA Networks. 2020;323:5
Peng Z. Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia. U.S. National Library of Medicine, Clinicaltrials.gov. 2020;Feb https://clinicaltrials.gov/ct2/show/NCT04264533
Roa F.J., Peña E., Gatica M. et.al. Therapeutic Use of Vitamin C in Cancer: Physiological Considerations. Frontiers in Pharmacology. 2020;11:211
Kim H., Jang M., Kim Y. et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. Journal of Parmacy and Pharmacology. 2016:68;3
Matthay M.A., Aldrich J.M., Gotts J.E. et. al. Treatment for severe acute respiratory distress syndrome from COVID-19. THE LANCET Respiratory Medicine. 2020;March.
Fowler A.A., Truwit J.D., Duncan Hite R. et.al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA. 2019:322;13
Jonsson B.H. Bör inte död vara ett primärt utfallsmått i sepsisstudier? Läkartidningen. 2020;Mar https://lakartidningen.se/opinion/debatt/2020/03/bor-inte-dod-vara-ett-primart-utfallsmatt-i-sepsisstudier/
Mongelli L, Golding B. New York hospitals treating coronavirus patients with vitamin C. New York Post. 2020;March https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/
Erol A. High-dose intravenous vitamin C treatment for COVID-19. Researchgate. 2020;Feb https://osf.io/p7ex8/

Kan man stärka sitt immunförsvar? av Peter Martin, leg läkare, med dr

Migrän – här är symtomen av Markus Mattiasson, biomedicinare och hälsoskribent

Varför får man migrän? av Markus Mattiasson, biomedicinare och hälsoskribent

Metoderna som lindrar av Markus Mattiasson, biomedicinare och hälsoskribent

Ett funktionsmedicinskt perspektiv – Den individuella migräntröskeln av Markus Mattiasson, biomedicinare och hälsoskribent’

Nr 2, 2020: Mitokondrier

Mitokondrierna – kroppens energiverk av Lina Åhlén, hälsoskribent

Marcheggiani F., Cirilli I., Orando P. et.al. Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. Aging. May 2019:10:11(9). https://www.ncbi.nlm.nih.gov/pubmed/31076563
Hsu C-C, Tseng L-M., Lee H-C. Role of mitochondrial dysfunction in cancer progression. 2016. March
Chen L., Knowlton A.A. Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardiology. 2010. Apr 58(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786553/
Mortiboys H., Macdonald R., Payne T. Translational approaches to restoring mitochondrial function in Parkinson’s disease. 2018. Jan (582). https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.12920
Pei-I T., Chin-Hsien L., Chung-Han H., et.al. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Molecular Cell. 2018 March 69(5). https://parkinsonsnewstoday.com/2018/02/27/defects-in-mitochondria-linked-to-parkinsons-stanford-study/
Perez Ortiz J.M., Swerdlow R.H. Mitochondrial dysfuncion in Alzheimer’s disease: Role in pathogenesis and novel therapeutic opportunities. British Journal of Pharmacology. 2019:176. https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.14585
Ames B., Liu J., Killilea D.W. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid. 2002. Feb 99(4). https://www.pnas.org/content/99/4/1876.short

Mitokondriefunktion – grundläggande för vår hälsa av Markus Mattiasson, biomedicinare och hälsoskribent

Metabolomik ger inblick i mitokondriens värld av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Astarita G, Langridge J. J Nutrigenet Nutrigenomics. 2013;6(4-5):181-200. An emerging role for metabolomics in nutrition science.
Chen Q et al. Front Cell Neurosci. 2019 Apr 30;13:150. Urine Organic Acids as Potential Biomarkers for Autism-Spectrum Disorder in Chinese Children.
Depeint F et al. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Filler K et al. BBA Clin. 2014 Jun 1;1:12-23. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature.
Gallagher R et al. Genetics in Medicine volume 20, pages 683–691(2018) Laboratory analysis of organic acids, 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
Guillemin GJ et al. FEBS J. 2012 Apr;279(8):1356-65. Quinolinic acid, the inescapable neurotoxin.
Kałużna-Czaplińska et al. Nutrition Research. Volume 31, Issue 7, July 2011, Pages 497-502. B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children
Longo et al. Biochim Biophys Acta. 2016 Oct; 1863(10): 2422–2435. CARNITINE TRANSPORT AND FATTY ACID OXIDATION
McKillop et al. Diabetes Care. 2011 Dec; 34(12): 2624–2630.
Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine
Moskowitz A et al. J Intensive Care Med. 2016 Mar;31(3):187-92. The Association Between Admission Magnesium Concentrations and Lactic Acidosis in Critical Illness.
Nordholme et al. Läkartidningen. 2016;113:DR7E Tiaminbrist orsakade laktacidos hos patient med malnutrition – Många patienter i behov av behandling med tiamin missas sannolikt.
Noto A et al. J Matern Fetal Neonatal Med. 2014 Oct;27 Suppl 2:46-52. The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings.
Orozco JS et al. Transl Psychiatry. 2019 Oct 3;9(1):243. Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.
Osiezagha, K et al. Innov Clin Neurosci. 2013 Apr; 10(4): 26–32. Thiamine Deficiency and Delirium
Pieczenik SR & Neustadt J. Exp Mol Pathol. 2007 Aug;83(1):84-92. Mitochondrial dysfunction and molecular pathways of disease.
Sun J et al. Per Med. 2013 Mar;10(2):149-161. Metabolomics as a tool for personalizing medicine: 2012 update.
Teagarden et al. Case Rep Crit Care. 2017;2017:5121032. Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient.
Tsoukalas D et al. Int J Mol Med. 2017 Jul;40(1):112-120. Application of metabolomics: Focus on the quantification of organic acids in healthy adults.

Deanna Minich – Vi måste ge mitokondrierna den näring de behöver av Nina Törmark, journalist

Fasta – ett kraftfullt verktyg för optimal hälsa av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Dror, et al. Postprandial macrophage-derived IL-1β stimulates insulin and both synergistically promote glucose disposal and inflammation. Nature Immunology, January 2017
Seillet et al. Nat Immunol. 2020 Feb;21(2):168-177. The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.
Anton et al. Obesity (Silver Spring). 2018 Feb;26(2):254-268. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
de Cabo & Mattson. N Engl J Med 2019;381:2541-51. Effects of Intermittent Fasting on Health, Aging, and Disease
Harvie & Howell. Potential benefits and harms of intermittent energy restriction and intermittent fasting amongst obese, overweight and normal weight subjects — a narrative review of human and animal evidence. Behav Sci (Basel) 2017; 7(1): E4.
Furmli et al. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Rep 2018; 2018:bcr-2017-221854.
Sutton et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab 2018; 27(6): 1212-1221.e3.
Nencioni et al. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 2018; 18: 707-19.
Choi et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep 2016; 15: 2136-46.
Fitzgerald et al. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord 2018; 23: 33-9.
Johnson et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 2007; 42: 665-74.
Cignarella et al. Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metab 2018; 27(6): 1222.e6-1235.e6.

Sött som socker men ändå inte av Pia Andrea, hälsoskribent

Nr 1, 2020: Oxalater

Tillsatserna som förvärrar stress Pia Andrea, hälsoskribent

Överkonsumtion av oxalater – en stundande hälsokris av Helene Sandström, vetenskapsjournalist

Testdata enligt The VP Foundation: www.thevpfoundation.org
Andrew Weil. ”How dangerous are oxalates?” Blogginlägg 2018-05-21. https://www.drweil.com/diet-nutrition/food-safety/how-dangerous-are-oxalates/. Läst 2019-10-24.
Michael Greger. ”Oxalates in Spinach and Kidney Stones: Should We Be Concerned?” Blogginlägg 2019-06-17. https://nutritionfacts.org/video/oxalates-in-spinach-and-kidney-stones-should-we-be-concerned/. Läst 2019-10-24.

Mer om oxalater: Norton, Sally K. (2018) ”Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity”, Journal of Evolution and Health: Vol. 2: Iss. 3, Article 4. https://doi.org/10.15310/2334-3591.1085

Oxalater som hälsoproblem – en funktionsmedicinsk betraktelse av Peter Martin, leg läkare, med dr

Kopplingen mellan oxalater och njursten av Mikaela Bjerring, näringsterapeut och hälsoskribent

Coe F. L., Evan A., Worcester E. Kidney stone disease. Journal of Clinical Investigation. 2005;115(10):2598–2608. doi: 10.1172/jci26662. https://www.ncbi.nlm.nih.gov/pubmed/16200192
Kidney Stone Disease: An Update on Current Concepts. Adv Urol. 2018; 2018: 3068365. Published online 2018 Feb 4. doi: 10.1155/2018/3068365. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817324/
Dal-Moro F., Mancini M., Tavolini I. M., De Marco V., Bassi P. Cellular and molecular gateways to urolithiasis: a new insight. Urologia Internationalis. 2005;74:193–197. doi: 10.1159/000083547. https://www.ncbi.nlm.nih.gov/pubmed/15812202
Kishore D. V., Moosavi F., Varma D. R. K. Effect of ethanolic extract of Portulaca oleracea linn. on ethylene glycol and ammonium chloride induced urolithiasis. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;5(2):134–140.
Kumar S. B. N., Kumar K. G., Srinivasa V., Bilal S. A review on urolithiasis. International Journal of Universal Pharmacy and Life Sciences. 2012;2(2):269–280.
Effects of citrate on the different phases of calcium oxalate crystallization. Scanning Microsc. 1993 Mar;7(1):381-9; discussion 389-90. https://www.ncbi.nlm.nih.gov/pubmed/8316807
Effect of Potassium Magnesium Citrate and Vitamin B-6 Prophylaxis for Recurrent and Multiple Calcium Oxalate and Phosphate Urolithiasis. Korean J Urol. 2014 Jun; 55(6): 411–416. Published online 2014 Jun 16. doi: 10.4111/kju.2014.55.6.411. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064051/
Calcium intake and urinary stone disease. Transl Androl Urol. 2014 Sep; 3(3): 235–240. doi: 10.3978/j.issn.2223-4683.2014.06.05. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708574/
Vitamin B6 intake and the risk of incident kidney stones. Urolithiasis. 2018 Jun;46(3):265-270. doi: 10.1007/s00240-017-0999-5. Epub 2017 Jul 3.https://www.ncbi.nlm.nih.gov/pubmed/28674784
Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. 1999 Apr;10(4):840-5. https://www.ncbi.nlm.nih.gov/pubmed/10203369
5 steps for preventing kidney stones. Posted October 04, 2013, 12:30 pm , Updated July 18, 2019. https://www.health.harvard.edu/blog/5-steps-for-preventing-kidney-stones-201310046721
Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. Journal of the American Society of Nephrology. 2009;20(10):2253–2259
https://ghr.nlm.nih.gov/condition/primary-hyperoxaluria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332067/
https://www.researchgate.net/publication/51048566_Physiological_roles_of_renal_anion_transporters_NaS1_and_Sat1

Lita på mig! Jag är läkare – säger Michael Mosley av Nina Törmark, journalist

Vi kommer ägna oss mer åt prevention av Nina Törmark, journalist

Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome
http://care.diabetesjournals.org/content/early/2018/12/09/dc18-141

Ny studie visar: Bättre livskvalitet med funktionsmedicin av Helene Sandström, vetenskapsjournalist

The Institute for Functional Medicine. Two years in: What’s happening at Cleveland Clinic’s Center for Functional Medicine https://www.ifm.org/partnerships/cleveland-clinic-center-for-functional-medicine/ Hämtad 2019-11-07.
Cleveland Clinic. Functioning for Life. https://my.clevelandclinic.org/departments/functional-medicine/programs/functioning-for-life-appointments Hämtad 2019-11-07.

Nr 6, 2019: Svamp och parasiter

Ost som främjar hälsan av Pia Andrea, hälsoskribent

Candida och svampdysbios – erfarenheter från funktionsmedicinsk praktik av Peter Martin, leg. läkare, med. dr.

A Homei, M. Worboys. 2013. Fungal Disease in Britain and the United States 1850-2000: Mycoses and Modernity. E-PDF ISBN 9781137377029. DOI 10.1057/9781137377029.
Erdogan A & Rao SS. Small intestinal fungal overgrowth. Curr Gastroenterol Rep. 2015 Apr;17(4):16. doi: 10.1007/s11894-015-0436-2.
https://www.internetmedicin.se/page.aspx?id=615
Roshonda B Jones et al 2018. Inter-niche and inter-individual variation in gut microbial community assessment using stool, rectal swab, and mucosal samples. Scientific Reportsvolume 8, Article number: 4139
https://www.nature.com/articles/s41598-018-22408-4

Bättre effekt mot malaria med extrakt av hel malört av Helene Sandström, vetenskapsjournalist

Wellcome Trust Sanger Institute. Multidrug-resistant malaria spreading in Asia: Study reveals importance of genomic surveillance for malaria control strategies. ScienceDaily. ScienceDaily, 23 July 2019.
Miotto O, Sekihara M, Tachibana S-I et al. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea bioRxiv. 2019, Aug.
Konstat-Korzenny E, Ascencio-Aragón JE, Niezen-Lugo S et al. Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Med Sci (Basel). 2018 Mar; 6(1): 19.
Munyangi J1, Cornet-Vernet L2, Idumbo M3 et al. Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial. Phytomedicine. 2019 Apr;57:49-56.
Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM.Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin.Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):821-6.
WHO. Effectiveness of Non-Pharmaceutical Forms of Artemisia annua L. against malaria. Position Statement, 2012.
WHO. Guidelines for the treatment of (uncomplicated) malaria. Third edition, 2015.
Remington L. A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions. Pharmacol Res Perspect. 2017 Aug; 5(4): e00328.
Crutzen B. The malaria business: Big pharma vs natural medicine. 2019-11-01.
https://www.france24.com/en/20190111-reporters-plus-malaria-business-big-pharma-vs-natural-medicine-artemisia-annua-who (hämtad 2019-08-17)
Munyangi J, Cornet-Vernet L, Idumbo M et al. Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine. 2018 Dec;51:233-240.
Rassias DJ, Weathers PJ. Dried leaf Artemisia annua efficacy against non-small cell lung cancer. Phytomedicine. 2019 Jan;52:247-253.

Uråldrig parasit påverkar den moderna människan av Linda Fång, närings- och hälsoskribent

Wellcome Trust Sanger Institute. Multidrug-resistant malaria spreading in Asia: Study reveals importance of genomic surveillance for malaria control strategies. ScienceDaily. ScienceDaily, 23 July 2019.
Miotto O, Sekihara M, Tachibana S-I et al. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea bioRxiv. 2019, Aug.
Konstat-Korzenny E, Ascencio-Aragón JE, Niezen-Lugo S et al. Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Med Sci (Basel). 2018 Mar; 6(1): 19.
Munyangi J1, Cornet-Vernet L2, Idumbo M3 et al. Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial. Phytomedicine. 2019 Apr;57:49-56.
Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM.Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):821-6.
WHO. Effectiveness of Non-Pharmaceutical Forms of Artemisia annua L. against malaria. Position Statement, 2012.
WHO. Guidelines for the treatment of (uncomplicated) malaria. Third edition, 2015.
Remington L. A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions. Pharmacol Res Perspect. 2017 Aug; 5(4): e00328.
Crutzen B. The malaria business: Big pharma vs natural medicine. 2019-11-01. https://www.france24.com/en/20190111-reporters-plus-malaria-business-big-pharma-vs-natural-medicine-artemisia-annua-who (hämtad 2019-08-17)
Munyangi J, Cornet-Vernet L, Idumbo M et al. Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial. Phytomedicine. 2018 Dec;51:233-240.
Rassias DJ, Weathers PJ. Dried leaf Artemisia annua efficacy against non-small cell lung cancer. Phytomedicine. 2019 Jan;52:247-253.

Kost och livsstisfaktorer som främjar eller hämmar svampöverväxt av Mikaela Bjerring, näringsterapeut och hälsoskribent

Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014 Jun;177(5-6):223-40. doi: 10.1007/s11046-014-9749-1. Epub 2014 May 1. https://www.ncbi.nlm.nih.gov/pubmed/24789109
The effects of hormonal contraceptives on glycemic regulation. Linacre Q. August, 2014; 81(3): 209–218. doi: 10.1179/2050854914Y.0000000023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135453/
Hormone contraceptives and how the body uses carbohydrates in women without diabetes. Published 30 April 2014, Authors: Lopez LM, Grimes DA, Schulz KF. https://www.cochrane.org/CD006133/FERTILREG_hormone-contraceptives-and-how-the-body-uses-carbohydrates-in-women-without-diabetes
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota Published online 2018 Sep 11. doi: 10.3389/fmicb.2018.02013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143810/
Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health. Published online 2018 Sep 24. doi: 10.3389/fendo.2018.00568. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165882/
Sleep and Microbes. Published online 2016 Aug 31. doi: 10.1016/bs.irn.2016.07.003 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441385/
Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomised controlled pilot study’ is published on Wednesday 10 January 2018 in the American Journal of Clinical Nutrition DOI: 10.1093/ajcn/nqx030 and https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqx030/4794751
Disruption of the Gut Ecosystem by Antibiotics. Published online 2017 Nov 29. doi: 10.3349/ymj.2018.59.1.4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725362/
Antibiotics destroy immune cells and worsen oral infection. https://thedaily.case.edu/study-antibiotics-destroy-immune-cells-worsen-oral-infection/
Disruption of the Gut Ecosystem by Antibiotics. Published online 2017 Nov 29. doi: 10.3349/ymj.2018.59.1.4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725362/
Yeast infection four times as likely with penicillin use. Publish date: August 21, 2013. https://www.mdedge.com/clinicianreviews/article/77427/infectious-diseases/yeast-infection-four-times-likely-penicillin-use
Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly. Braz Dent J. 2012;23(5):534-8. https://www.ncbi.nlm.nih.gov/pubmed/23306230/
A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015 Apr;24(3):194-9. doi: 10.1111/jopr.12198. Epub 2014 Aug 20. https://www.ncbi.nlm.nih.gov/pubmed/25143068/
Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015 Sep;94(9 Suppl):181S-6S. doi: 10.1177/0022034515595950. Epub 2015 Jul 22. https://www.ncbi.nlm.nih.gov/pubmed/26202995/
Antifungal activity of clinical Lactobacillus strains against Candida albicans biofilms: identification of potential probiotic candidates to prevent oral candidiasis. Biofouling. 2018 Feb;34(2):212-225. doi 10.1080/08927014.2018.1425402. Epub 2018 Jan 30. https://www.ncbi.nlm.nih.gov/pubmed/29380647
Purification and partial characterization of novel bacteriocin L23 produced by Lactobacillus fermentum L23. Curr Microbiol. 2008 Apr;56(4):397-402. doi: 10.1007/s00284-007-9094-4. Epub 2008 Jan 3. https://www.ncbi.nlm.nih.gov/pubmed/18172715/
Anti-Candida activity of two-peptide bacteriocins, plantaricins (Pln E/F and J/K) and their mode of action. Fungal Biol. 2014 Feb;118(2):264-75. doi: 10.1016/j.funbio.2013.12.006. Epub 2014 Jan 9. https://www.ncbi.nlm.nih.gov/pubmed/24528647/
Characterization of pentocin TV35b, a bacteriocin-like peptide isolated from Lactobacillus pentosus with a fungistatic effect on Candida albicans. J Appl Microbiol. 1999 Nov;87(5):726-34. https://www.ncbi.nlm.nih.gov/pubmed/10594714/
Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother. 1988 Dec;32(12):1854-8. https://www.ncbi.nlm.nih.gov/pubmed/3245697/
Probiotics Prevent Candida Colonization and Invasive Fungal Sepsis in Preterm Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pediatr Neonatol. 2017 Apr;58(2):103-110. doi: 10.1016/j.pedneo.2016.06.001. Epub 2016 Sep 14. https://www.ncbi.nlm.nih.gov/pubmed/27793494
Comparing the Recurrence of Vulvovaginal Candidiasis in Patients Undergoing Prophylactic Treatment with Probiotic and Placebo During the 6 Months. Probiotics Antimicrob Proteins. 2016 Sep;8(3):130-3. doi: 10.1007/s12602-016-9218-x.
Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem. 2001 Dec;228(1-2):111-7. https://www.ncbi.nlm.nih.gov/pubmed/11855736
Mechanism of Antifungal Activity of Terpenoid Phenols Resembles Calcium Stress and Inhibition of the TOR Pathway. Antimicrob Agents Chemother. 2010 Dec; 54(12): 5062–5069. Published online 2010 Oct 4. doi: 10.1128/AAC.01050-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981246/#r4
Sensitivity of Candida albicans to essential oils: are they an alternative to antifungal agents? J Appl Microbiol. 2016 Dec;121(6):1530-1545. doi: 10.1111/jam.13282. Epub 2016 Oct 24. https://www.ncbi.nlm.nih.gov/pubmed/27568869
Caprylic acid in the effective treatment of intractable medical problems of frequent urination, incontinence, chronic upper respiratory infection, root canalled tooth infection, ALS, etc., caused by asbestos & mixed infections of Candida albicans, Helicobacter pylori & cytomegalovirus with or without other microorganisms & mercury. Acupunct Electrother Res. 2011;36(1-2):19-64. https://www.ncbi.nlm.nih.gov/pubmed/21830350
The Dietary Food Components Capric Acid and Caprylic Acid Inhibit Virulence Factors in Candida albicans Through Multitargeting. J Med Food. 2017 Nov;20(11):1083-1090. doi: 10.1089/jmf.2017.3971. Epub 2017 Sep 18. https://www.ncbi.nlm.nih.gov/pubmed/28922057
Hexosomes with Undecylenic Acid Efficient against Candida albicans. Nanomaterials (Basel). 2018 Feb; 8(2): 91. Published online 2018 Feb 7. doi: 10.3390/nano8020091. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853723/
Page 68Alternative Medicine ReviewVolume 7, Number 12002Undecylenic Acid. MonographCopyright©2002 Thorne Research, Inc. http://altmedrev.com/archive/publications/7/1/68.pdf
Sugar Sensing and Signaling in Candida albicans and Candida glabrata. Front Microbiol. 2019 Jan 30;10:99. doi: 10.3389/fmicb.2019.00099. eCollection 2019. https://www.ncbi.nlm.nih.gov/pubmed/30761119
Svamp utnyttjar syrebrist för att sprida sig i kroppen. Artikel från Umeå universitet, 23 januari, 2019. https://www.forskning.se/2019/01/23/svamp-utnyttjar-syrebrist-for-att-sprida-sig-i-kroppen/
Production of pyruvate by Candida albicans: proposed role in virulence. FEMS Microbiol Lett. 2000 Sep 1;190(1):35-8. https://www.ncbi.nlm.nih.gov/pubmed/10981686
Evaluation of the relationship between fungal infection, neutrophil leukocytes and macrophages in cervicovaginal smears: Light microscopic examination. J Cytol. 2015 Apr-Jun; 32(2): 79–84. doi: 10.4103/0970-9371.160544. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520052/
Effect of prolonged modified fasting in obese persons on in vitro markers of immunity: lymphocyte function and serum effects on normal neutrophils. Am J Med Sci. 1990 Jun;299(6):379-85. https://www.ncbi.nlm.nih.gov/pubmed/2356851
Glucose Directly Promotes Antifungal Resistance in the Fungal Pathogen, Candida spp.An external file that holds a picture, illustration, etc. Object name is sbox.jpg. J Biol Chem. 2014 Sep 12; 289(37): 25468–25473. Published online 2014 Jul 22. doi: 10.1074/jbc.C114.571778. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162151/
Candida sp. Infections in Patients with Diabetes Mellitus. J Clin Med. 2019 Jan; 8(1): 76. Published online 2019 Jan 10. doi: 10.3390/jcm8010076. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352194/

Missing microbes – en orsak till autoimmuna sjukdomar? Nina Törmark, journalist

Human microbiome project: https://hmpdacc.org
Moises hemsida med hans TED-talk: http://www.moisesvm.com
Maskar och Chrohns: https://www.sciencemag.org/news/2016/04/parasitic-worms-may-prevent-crohn-s-disease-altering-bacterial-balance
Läs mer om MS och parasiter: https://www.mstrust.org.uk/a-z/parasitic-worms

Svamp som orsak till vanliga välfärdssjukdomar av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Floreani A, Leung PS, Gershwin ME. Clin Rev Allergy Immunol. 2016 Jun;50(3):287-300. Environmental Basis of Autoimmunity.
Garth L. Nicolson and Jörg Haier. BJMP 2010a;3(1):301. Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioural, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 1
Garth L. Nicolson and Jörg Haier. BJMP 2010b;3(1):301. Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioural, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 2
Lei Yan, Chunhui Yang, Jianguo Tang. Microbiological Research. Volume 168, Issue 7, 25 August 2013, Pages 389-395. Review Article. Disruption of the intestinal mucosal barrier in Candida albicans infections
Tsavkelova E.A., Botvinko I.V., Kudrin V.S., Oleskin A.V. Detection of neurotransmitter amines in microorganisms with the use of high-performance liquid chromatography. Dokl. Biochem. Proc. Acad. Sci. USSR Biochem. Sect. 2000;372:115–117.
Cryan J. F., Dinan T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13 701–712. 10.1038/nrn3346
Voropaeva E.A. Resistance to antibiotics and histamine production at the bacteria, isolated from the stomatopharynx of the children with bronchial asthma. Antibiot. Khimioterapiia Antibiot. Chemoterapy Sic. 2002;47:8–13.
Parady B. J Alzheimers Dis Rep. 2018; 2(1): 139–152. Published online 2018 Aug 1. Innate Immune and Fungal Model of Alzheimer’s Disease
Claudia Jiménez-López and Michael C. Lorenz. PLoS Pathog. 2013 Nov; 9(11): e1003741. Fungal Immune Evasion in a Model Host–Pathogen Interaction: Candida albicans Versus Macrophages
Alessandra da Silva Dantas, Kathy K Lee, Ingrida Raziunaite, Katja Schaefer, Jeanette Wagener, Bhawna Yadav, Neil ARGow. Current Opinion in Microbiology. Volume 34, December 2016, Pages 111-118. Cell biology of Candida albicans–host interactions
Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D. PLoS Pathog. 2012;8(6):e1002777. Candida albicans scavenges host zinc via Pra1 during endothelial invasion.
Ranjan A, Dongari-Bagtzoglou A. J Fungi (Basel). 2018 Sep 18;4(3). pii: E112. Tipping the Balance: C. albicans Adaptation in Polymicrobial Environments.
Giorgia Renga, Silvia Moretti, Vasilis Oikonomou, Monica Borghi, Teresa Zelante, Giuseppe Paolicelli, Claudio Costantini, Marco De Zuani, Valeria Rachela Villella, Valeria Raia, Rachele Del Sordo, Andrea Bartoli, Monia Baldoni, Jean-Christophe Renauld, Angelo Sidoni, Enrico Garaci, Luigi Maiuri, Carlo Pucillo, and Luigina Romani. Cell Rep. 2018 May 8; 23(6): 1767–1778. IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut
Matthew L. Wheeler, Jose J. Limon, Agnieszka S. Bar, Christian A. Leal, Matthew Gargus, Jie Tang, Jordan Brown, Vincent A. Funari, Hanlin L. Wang, Timothy Crother, Moshe Arditi, David M. Underhill and Iliyan D. Iliev. Cell Host Microbe. Cell Host Microbe. 2016 Jun 8; 19(6): 865–873. Immunological Consequences of Intestinal Fungal Dysbiosis
Sokol H., Leducq V., Aschard H., Pham H.-P., Jegou S., Landman C., Cohen D., Liguori G., Bourrier A., Nion-Larmurier I., et al. Fungal microbiota dysbiosis in IBD. Gut. 2017;66:1039–1048.
Hager CL, Ghannoum MA. Dig Liver Dis. 2017 Nov;49(11):1171-1176. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease.
Liguori G, Lamas B, Richard ML, Brandi G, da Costa G, Hoffmann TW, Di Simone MP, Calabrese C, Poggioli G, Langella P, Campieri M, Sokol H. J Crohns Colitis. 2016 Mar;10(3):296-305. Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients.
Miyoshi J, Sofia MA, Pierre JF. Clin J Gastroenterol. 2018 Dec;11(6):449-456. The evidence for fungus in Crohn’s disease pathogenesis.
Wcislo-Zwolinska, Malgorzata, et al. Gastroenterology, vol. 134, no. 4, 2008. W1783 Effect of Combined Antifungeal and Probiotic Therapy On Candida Colonization of Human Ulcerative Colitis and the Healing of Colonic Injury in Experimental Animal Model of Colitis Ulcerosa.
Zwolinska-Wcislo M, Brzozowski T, Budak A, Kwiecien S, Sliwowski Z, Drozdowicz D, Trojanowska D, Rudnicka-Sosin L, Mach T, Konturek SJ, Pawlik WW. J Physiol Pharmacol. 2009 Mar;60(1):107-18. Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa.
Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM. Gastroenterology. 2017 Oct;153(4):1026-1039. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O. Cell Microbiol. 2016 Jul;18(7):889-904. Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.
Raphaël Enaud, Louise-Eva Vandenborght, Noémie Coron, Thomas Bazin, Renaud Prevel, Thierry Schaeverbeke, Patrick Berger, Michael Fayon, Thierry Lamireau, and Laurence Delhaes. Microorganisms. 2018 Mar; 6(1): 22. The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
Alonso R, Pisa D, Fernández-Fernández AM, Rábano A, Carrasco L. Neurobiol Dis. 2017 Dec;108:249-260. Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.
Francesco Strati, Duccio Cavalieri, Davide Albanese, Claudio De Felice, Claudio Donati, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Antonio Calabrò, and Carlotta De Filippo. Microbiome. 2017; 5: 24. New evidences on the altered gut microbiota in autism spectrum disorders
Severance EG, Yolken RH. Curr Top Behav Neurosci. 2019 Mar 8. From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia.
Alonso R, Fernández-Fernández AM, Pisa D, Carrasco L. Neurobiol Dis. 2018 Sep;117:42-61. Multiple sclerosis and mixed microbial infections. Direct identification of fungi and bacteria in nervous tissue.
Epp LM, Mravec B. Bratisl Lek Listy. 2006;107(6-7):227-30. Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson’s disease.
Severance EG, Gressitt KL, Stallings CR, Katsafanas E, Schweinfurth LA, Savage CLG, Adamos MB, Sweeney KM, Origoni AE, Khushalani S, Dickerson FB, Yolken RH. Brain Behav Immun. 2017 May;62:41-45. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study.
Logsdon AF, Erickson MA, Rhea EM, Salameh TS, Banks WA. Exp Biol Med (Maywood). 2018 Jan;243(2):159-165. Gut reactions: How the blood-brain barrier connects the microbiome and the brain.
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Robert D.Moir, Richard Lathe, Rudolph E. Tanzia. Alzheimer’s & Dementia. Volume 14, Issue 12, December 2018, Pages 1602-1614. The antimicrobial protection hypothesis of Alzheimer’s disease
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Alonso R, Pisa D, Aguado B, Carrasco L.J Alzheimers Dis. 2017;58(1):55-67. Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing.

Nr 5, 2019: Kollagen

Kaffe – den älskade svarta drycken, Pia Andra, hälsoskribent

Kollagen – ett tillskott för hud, skelett, senor och leder, Jonas Bergqvist, leg sjukgymnast, utbildare

Marlyn Wu; Jonathan S. Crane; Biochemistry, Collagen Synthesis; 2018
Mienaltowski MJ & Birk DE; Structure, physiology, and biochemistry of collagens; Adv Exp Med Biol. 2014;802:5-29.
Vieira CP et al; Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon; Anat Rec (Hoboken). 2015 Mar;298(3):538-45.
Franceschi RT et al; Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res. 1994 Jun;9(6):843-54.
Ganta DR et al; Ascorbic acid alters collagen integrins in bone culture; Endocrinology. 1997 Sep;138(9):3606-12.
Harada S et al; Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-E1 cells; J Bone Miner Res. 1991 Sep;6(9):903-8.
DePhillipo N N et al; Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review; Orthop J Sports Med. 2018 Oct 25;6(10):2325967118804544; 2018 Oct.
Figueres Juher T et al; An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing; Nutr Hosp. 2015 Jul 18;32 Suppl 1:62-6
Asserin J et al; The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials; J Cosmet Dermatol. 2015 Dec;14(4):291-301.
10. McAlindon TE et al; Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial; Osteoarthritis Cartilage. 2011 Apr;19(4):399-405.
Langberg H et al; Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans; J Physiol. 2001 Jul 1;534(Pt 1):297-302.
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Heinemeier KM et al; Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle; J Appl Physiol (1985). 2009 Jan;106(1):178-86.
Couppé C et al; Habitual loading results in tendon hypertrophy and increased stiffness of the human patellar tendon. J Appl Physiol (1985). 2008 Sep;105(3):805-10.
Shaw G et al; Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis; Am J Clin Nutr. 2017 Jan;105(1):136-143.
Clark KL et al; 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain; Curr Med Res Opin. 2008 May;24(5):1485-96.

Kollagenets betydelse för ledhälsan, Mikaela Bjerring, näringsterapeut och hälsoskribent

(1) Kollagen gav god effekt vid knäartros: http://www.ncbi.nlm.nih.gov/pubmed/26822714

(2) Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764342

(3) Effects of oral administration of type II collagen on rheumatoid arthritis: https://www.ncbi.nlm.nih.gov/pubmed/8378772

(4) 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain: https://www.ncbi.nlm.nih.gov/pubmed/18416885

(5) Efficacy of specific bioactive collagen peptides in the treatment of joint pain: https://www.oarsijournal.com/article/S1063-4584(16)00389-7/abstract

(6) L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent: https://www.ncbi.nlm.nih.gov/pubmed/12589194

C-vitamin för en frisk bindväv, Nina Törmark, journalist

1. Skörbjugg i USA https://www.sciencealert.com/scurvy-coming-back-vitamin-c-poverty-massachusetts-boston-vitamania-movie

2. C-vitaminbrist bland svårt sjuka https://www.ncbi.nlm.nih.gov/pubmed/20018480

3. Skörbjugg hos barn med autism https://www.ncbi.nlm.nih.gov/pubmed/26590972

4. Parodontos C-vitaminbrist https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193894/ och https://www.livestrong.com/article/521960-how-much-vitamin-c-to-take-for-periodontal-disease/

5: EFSA https://www.efsa.europa.eu/en/efsajournal/pub/3257.

6. Positiva effekter av kollagen https://www.ncbi.nlm.nih.gov/pubmed/30681787

7. Kisel https://www.ncbi.nlm.nih.gov/pubmed/27548886

8. Histidin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634381/

9. Livsmedelsverket: https://www.livsmedelsverket.se/livsmedel-och-innehall/naringsamne/livsmedelsdatabasen

Kollagen – kan det spela roll vid diabetes och dess följdsjukdomar, Anette Lindqvist, näringsmedicinare, skribent

1. Paul RG, Bailey AJ. Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol. 1996 Dec;28 (12):1297-310. https://www.ncbi.nlm.nih.gov/pubmed/9022289

2 . Richard Yan-Do Patrick E. MacDonald Impaired “Glycine”-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis Endocrinology, Volume 158, Issue 5, 1 May 2017, Pages 1064–1073, https://academic.oup.com/endo/article/158/5/1064/3070537

3. Gannon MC1, Nuttall JA, Nuttall FQ. Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis VA Medical Center, University of Minnesota, Minneapolis 55417, USA. ganno004@tc.umn.edu The metabolic response to ingested glycine.
Am J Clin Nutr. 2002 Dec;76(6):1302-7. https://www.ncbi.nlm.nih.gov/pubmed/12450897

4 (1). Ericson E & Ericson T (2012) Medicinska sjukdomar. Studentlitteratur Lund. https://www.hjart-lung.se/vart-arbete/tidningen-status/artiklar/darfor-okar-diabetes-risken-for-hjart-karlsjukdom/

4 (2). Edsfeldt A1, Gonçalves I2, Grufman H2, Nitulescu M2, Dunér P2, Bengtsson E2, Mollet IG2, Persson A2, Nilsson M2, Orho-Melander M2, Melander O2, Björkbacka H2, Nilsson J2. Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2143-50. doi https://www.ncbi.nlm.nih.gov/pubmed/25035341

5. Diabets portalen, Lunds universitet. https://www.diabetesportalen.lu.se/forskning/avhandlingar/2013/att-upptacka-sarbara-plack

Övriga Källor

https://www.ncbi.nlm.nih.gov/pubmed/25035341

http://www.lakartidningen.se/Functions/OldArticleView.aspx?articleId=8397

https://www.diabetes.fi/sv/diabetesforbundet_i_finland/om_diabetes

http://publikdocplus.regionuppsala.se/Home/GetDocument?containerName=e0c73411-be4b-4fee-ac09-640f9e2c5d83&reference=DocPlusSTYR-14234&docId=DocPlusSTYR-14234

http://www.kollagen.nu/mat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951818/

https://www.furtherfood.com/collagen-protein-stabilize-blood-sugar-diabetes-restore-collagen-production-diabetics/

Minska nedbrytningen av kollagen med fytonäringsämnen, Lina Åhlén, BSc Nutritional Science

1. Chang S-W, Buehler M.J. Molecular biomechanics of collagen molecules. Materials Today. 2014;17:2

2. Pittayapruek P., Meephansan J., Prapapan O. et.al. Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. International Journal of Molecular Science. 2016;17:6.

3. Christie S., Walker A.F., Hicks S.M., Abeyasekera S. Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-blind, placebo-controlled study. Phytomedicine. 2004;11:1

4. Christie, S., Barlow, A. et al. (eds.) (2012) Colladeen Study (LOTCOL I and II) Lamberts Healthcare Ltd.; Aspen Clinical Research, Maldon, Essex, UK

5. Bae J.Y., Lim S.S., Kim S.J. et al. Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts Molecular Nutrition & Food Research. 2009;53:6

6. Matchett M.D., MacKinnon S.L., Sweeney M.I., et.al. Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochemistry and Cell Biology 2005;83:5

7. Du C., Smith A., Avalos M. et.al. Blueberries Improve Pain, Gait Performance, and Inﬂammation in Individuals with Symptomatic Knee Osteoarthritis. Nutrients. 2019;11:290

8. Roh E., Kim J-E., Kwon J.Y. et.al. Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Critical Reviews in Food Science and Nutrition. 2017;57:8

9. Nichols J.A, Katiyar S.K. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Archives of Dermatol Research. 2010;302:2

10. Vayalil P.K., Mittal A., Hara Y. et.al. Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin. Journal of Investigative Dermatology. 2004;122:6

11. Lephart E.D., Sommerfeldt J.M., Andrus M.B. Resveratrol: inﬂuences on gene expression in human skin. Journal of Functional Foods. 2014;10

12. Offord E.A et.al. Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free radical biology and medicine. 2002; 32:12

Nr 4, 2019: Matsmältning

Spännande smaker med god näring, Pia Andrea, hälsoskribent

1. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

2. https://products.mercola.com/fermented-beet-powder/

3. https://products.mercola.com/fermented-beet-powder/

4. https://nourishedkitchen.com/green-veggie-powder/

5. https://healthyeating.sfgate.com/calories-dried-vegetables-3798.html

6. https://www.livestrong.com/article/340760-nutritional-value-of-dehydrated-vegetables/

7. https://extension2.missouri.edu/gh1562

8. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

9. https://www.amazon.com/Homesteading-Handbook-vol-Food-Drying/dp/1500669946

Människans artriktiga kost, Jonas Bergqvist, leg sjukgymnast, utbildare

1. Fumagalli Matteo et al; Greenlandic Inuit show genetic signatures of diet and climate adaptation; Science 18 September 2015: Vol. 349 no. 6254 pp. 1343-1347

2. Roseboom TJ; Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview; Molecular and Cellular Endocrinology 185 (2001) 93–98

3. Henry AG, Brooks AS, Piperno DR. Microfossils in calculus demonstrate consumption of plants and cooked foods in Neanderthal diets. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):486-91

Så påverkas din matsmältning av stress, Mikaela Bjerring, näringsterapeut, hälsoskribent

1. Effects of occupational stress on the gastrointestinal tract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829457/

2. The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398234/

3. The bowel and beyond: the enteric nervous system in neurological disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005185/

4. Stress and the sensitive gut: https://www.health.harvard.edu/newsletter_article/stress-and-the-sensitive-gut

5. Enzyme Science: https://enzyscience.com/pages/enzyme-faq

6. Neural and Hormonal Regulation of Pancreatic Secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838392/

7. Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868080/

8. Introduction to the human gut microbiota: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/

9. Gut microbiota functions: metabolism of nutrients and other food components: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847071/

10. Stress & the gut-brain axis: Regulation by the microbiome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736941/

11. Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions: https://www.ncbi.nlm.nih.gov/pubmed/20941511

12. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/

13. Stress and the gut: Pathophysiology, clinic consequences, diagnostic approach and treatment option http://www.jpp.krakow.pl/journal/archive/12_11/pdf/591_12_11_article.pdf

14. Stressor Exposure Disrupts Commensal Microbial Populations in the Intestines and Leads to Increased Colonization by Citrobacter rodentium: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849416/

15. Exposure to a Social Stressor Alters the Structure of the Intestinal Microbiota: Implications for Stressor-Induced Immunomodulation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039072/

16. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options: https://www.ncbi.nlm.nih.gov/pubmed/22314561

17. Stress and the gut: Pathophysiology, clinic consequences, diagnostic approach and treatment option http://www.jpp.krakow.pl/journal/archive/12_11/pdf/591_12_11_article.pdf

18. How Stress Contributes to SIBO: https://kresserinstitute.com/how-stress-contributes-to-sibo/

19. Gut Pathogens: https://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-3-1

PPI – medicin med sur eftersmak, Linus Mårtensson, leg läkare, specialist i allmänmedicin

1. Agréus MS. Sjukdomar i matstrupe, magsäck och tolvfingertarm | Läkemedelsboken [Internet]. [cited 2019 Mar 27]. Available from: https://lakemedelsboken.se/kapitel/mage-tarm/sjukdomar_i_matstrupe_magsack_och_tolvfingertarm.html

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4. Smith JL. The role of gastric acid in preventing foodborne disease and how bacteria overcome acid conditions. J Food Prot. 2003 Jul;66(7):1292–303.

5. Tennant SM, Hartland EL, Phumoonna T, Lyras D, Rood JI, Robins-Browne RM, et al. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infect Immun. 2008 Feb;76(2):639–45.

6. Zhu H, Hart CA, Sales D, Roberts NB. Bacterial killing in gastric juice–effect of pH and pepsin on Escherichia coli and Helicobacter pylori. J Med Microbiol. 2006 Sep;55(Pt 9):1265–70.

7. Parasa S, Sharma P. Complications of gastro-oesophageal reflux disease. Best Pract Res Clin Gastroenterol. 2013 Jun;27(3):433–42.

8. Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J. Esophageal sensation and esophageal hypersensitivity – overview from bench to bedside. J Neurogastroenterol Motil. 2010 Oct 30;16(4):353–62.

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10. Boeckxstaens GE. The lower oesophageal sphincter. Neurogastroenterol Motil. 2005 Jun;17 Suppl 1:13–21.

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16. Nasser SC, Slim M, Nassif JG, Nasser SM. Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes. World J Gastroenterol. 2015 Apr 21;21(15):4599–606.

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18. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994 Feb 1;120(3):211–5.

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36. Charlot M, Ahlehoff O, Norgaard ML, Jørgensen CH, Sørensen R, Abildstrøm SZ, et al. Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Ann Intern Med. 2010 Sep 21;153(6):378–86.

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40. Akter S, Hassan MR, Shahriar M, Akter N, Abbas MG, Bhuiyan MA. Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software. Alzheimers Res Ther. 2015 Dec 27;7:79.

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42. Huang W-S, Bai Y-M, Hsu J-W, Huang K-L, Tsai C-F, Su T-P, et al. Use of Proton Pump Inhibitors and Risk of Major Depressive Disorder: A Nationwide Population-Based Study. Psychother Psychosom. 2018 Jan 6;87(1):62–4.

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Nr 5, 2019: Funktionsmedicin

Är det slut för den gröna trenden?, Pia Andrea hälsoskribent

1. https://www.youtube.com/watch?feature=youtu.be&v=j3TT0N0eXwo&fbclid=IwAR3tvlsZsmjRcxPZA4k7QU-0ol1GmbGhv23gkW8P-gcuTHfu2RsHrm_p0_A&app=desktop

2. https://namedprogram.com/elimination-of-oxalates-for-post-traumatic-stress-disorder/

3. https://www.healthline.com/health/what-is-a-low-oxalate-diet

4. https://www.youtube.com/watch?feature=youtu.be&v=j3TT0N0eXwo&fbclid=IwAR3tvlsZsmjRcxPZA4k7QU-0ol1GmbGhv23gkW8P-gcuTHfu2RsHrm_p0_A&app=desktop

5. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

6. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

7. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

8. https://www.youtube.com/watch?v=fFF55stxVIw&list=PLXRAr-zqLf7NOnKyfUfYR0BOiu2Y1XXAw

9. https://drjockers.com/low-oxalate-diet/

10. https://drjockers.com/low-oxalate-diet/

11. https://drjockers.com/low-oxalate-diet/

12. https://drjockers.com/low-oxalate-diet/

13. https://www.mindbodygreen.com/0-25765/are-green-juices-smoothies-actually-healthy-a-cardiologist-explains.html

14. https://www.youtube.com/watch?v=xqUO4P9ADI0&feature=youtu.be&fbclid=IwAR0ksi10ibRbHVmQeAnHqj9oF7yaxGO5mrmPDO_mYpskDjuVksm90TT_LcE

15. https://my.clevelandclinic.org/health/articles/11066-kidney-stones-oxalate-controlled-diet

16. https://www.healthline.com/nutrition/oxalate-good-or-bad#section8

Funktionsmedicin – ett paradigmskifte på gång, Peter Martin, leg.läkare, med dr.

1. Rappaport, 2016.

2. Nielsen J, 2017.

3. Hanaway, 2016

4. Chung et al, 2013.

5. Chung et al. Nutrition education in European medical schools: results of an international survey. European Journal of Clinical Nutrition (2014) 68, 844–846

6. Hanaway P. Form Follows Function: A Functional Medicine Overview Perm J 2016 Fall;20(4):16-109

7. Loscalzo J and Barabasi A-L. Systems Biology and the Future of Medicine. Wiley Interdiscip Rev Syst Biol Med . 2011 November ; 3(6): 619–627

8. Nielsen J. Systems Biology of Metabolism. Annual Review of Biochemistry. Vol. 86:245-275

9. Rappaport SM (2016) Genetic Factors Are Not the Major Causes of Chronic Diseases. PLoS ONE 11(4)

Människans artriktiga kost, Jonas Bergqvist, leg sjukgymnast, utbildare

1. Fumagalli Matteo et al; Greenlandic Inuit show genetic signatures of diet and climate adaptation; Science 18 September 2015: Vol. 349 no. 6254 pp. 1343-1347

2. Roseboom TJ; Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview; Molecular and Cellular Endocrinology 185 (2001) 93–98

3. Henry AG, Brooks AS, Piperno DR. Microfossils in calculus demonstrate consumption of plants and cooked foods in Neanderthal diets. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):486-91

Alltid trött? Funktionsmedicin kan ge dig svaren, Mikaela Bjerring, näringsterapeut och hälsoskribent

1. The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability. https://www.ncbi.nlm.nih.gov/pubmed/26081141

2. Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med. 2011 Mar 14;208(3):417-20.

3. Spence VA, Kennedy G, Belch JJ, Hill A, Khan F. Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome. Clin Sci (Lond). 2008 Apr;114(8):561-6.

4. Raison CL, Lin JM, Reeves WC. Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain Behav Immun. 2009 Mar;23(3):327-37.

5. Brinkley TE, Leng X, et al. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):455-61.

6. Christian LM, Glaser R, et al. Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrinology. 2011 Nov;36(10):1495-504.

7. Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course. https://www.ncbi.nlm.nih.gov/pubmed/23399438

8. Increased number of Candida albicans in the faecal microflora of chronic fatigue syndrome patients during the acute phase of illness. https://www.ncbi.nlm.nih.gov/pubmed/17886123

9. Non-celiac gluten sensitivity and rheumatic diseases https://www.ncbi.nlm.nih.gov/pubmed/25956352

10. Effect of folic acid and vitamin B12 supplementation on DNA methylation https://www.wcrf.org/int/research-we-fund/what-we-re-funding/effect-folic-acid-and-vitamin-b12-supplementation-dna

11. DNA Methylation Modifications Associated with Chronic Fatigue Syndrome: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104757

12. Mitochondrial dysfunction and molecular pathways of disease. https://www.ncbi.nlm.nih.gov/pubmed/17239370

13. TheBmj Mitochondrial research: https://www.bmj.com/content/335/7623/747

14. Association of mitochondrial dysfunction and fatigue: A review of the literature. https://www.sciencedirect.com/science/article/pii/S221464741400004X