Nr 2 2025 — Lymfsystemet

Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495-510.

Petit C. Nigella Seeds: Vicks inhaler of Ancient Greece and modern Marrakech. Warwick University, 2014. https://warwick.ac.uk/news/knowledge-archive/arts/nigellaseeds/

He Y, Hu X, Chang L, Liu S, Lv L, Qin G, Jiang L. Meta-analysis of randomized controlled trials assessing the efficacy of nigella sativa supplementation for allergic rhinitis treatment. Front Pharmacol. 2024 Sep 20;15:1417013.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May;3(5):337-52.

1.     Moore JE Jr, Bertram CD. Lymphatic System Flows. Annu Rev Fluid Mech. 2018 Jan;50:459-482. doi: 10.1146/annurev-fluid-122316-045259. PMID: 29713107; PMCID: PMC5922450.

2.     Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. Lymphatic Vessel Network Structure and Physiology. Compr Physiol. 2018 Dec 13;9(1):207-299. doi: 10.1002/cphy.c180015. PMID: 30549020; PMCID: PMC6459625.

3.     Schulze H, Nacke M, Gutenbrunner C, Hadamitzky C. Worldwide assessment of healthcare personnel dealing with lymphoedema. Health Econ Rev. 2018 Apr 16;8(1):10. doi: 10.1186/s13561-018-0194-6. PMID: 29663122; PMCID: PMC5901432.

4.     Morfoisse F, Tatin F, Chaput B, Therville N, Vaysse C, Métivier R, Malloizel-Delaunay J, Pujol F, Godet AC, De Toni F, Boudou F, Grenier K, Dubuc D, Lacazette E, Prats AC, Guillermet-Guibert J, Lenfant F, Garmy-Susini B. Lymphatic Vasculature Requires Estrogen Receptor-α Signaling to Protect From Lymphedema. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1346-1357. doi: 10.1161/ATVBAHA.118.310997. Epub 2018 Apr 12. PMID: 29650694.

5.     Gashev AA, Zawieja DC. Hydrodynamic regulation of lymphatic transport and the impact of aging. Pathophysiology. 2010 Sep;17(4):277-87. doi: 10.1016/j.pathophys.2009.09.002. Epub 2010 Mar 11. PMID: 20226639; PMCID: PMC5507682.

6.     Keast, D., & Towers, A. (2017). The rising prevalence of lymphedema in Canada: A continuing dialogue. Lymphedema Pathways, Spring, 5–8.

7.     Hespe GE, Kataru RP, Savetsky IL, García Nores GD, Torrisi JS, Nitti MD, Gardenier JC, Zhou J, Yu JZ, Jones LW, Mehrara BJ. Exercise training improves obesity-related lymphatic dysfunction. J Physiol. 2016 Aug 1;594(15):4267-82. doi: 10.1113/JP271757. Epub 2016 Apr 9. PMID: 26931178; PMCID: PMC4967732.

8.     Admoun C, Mayrovitz HN. Coping Mechanisms for Lymphedema: An Analysis of Patient Experiences. Cureus. 2023 Jul 8;15(7):e41573. doi: 10.7759/cureus.41573. PMID: 37554614; PMCID: PMC10406395.

9.     Svenska Ödemförbundet https://www.youtube.com/watch?v=Op2wrBQ63OM

10.Stewart JM, Karman C, Montgomery LD, McLeod KJ. Plantar vibration improves leg fluid flow in perimenopausal women. Am J Physiol Regul Integr Comp Physiol. 2005 Mar;288(3):R623-9. doi: 10.1152/ajpregu.00513.2004. Epub 2004 Oct 7. PMID: 15472009.

11.Schneider R. Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: A two-armed, randomized, controlled pragmatic trial. Physiother Theory Pract. 2020 Jan;36(1):63-70. doi: 10.1080/09593985.2018.1479474. Epub 2018 May 30. PMID: 29847188.

12.Keith L, Rowsemitt C, Richards LG. Lifestyle Modification Group for Lymphedema and Obesity Results in Significant Health Outcomes. Am J Lifestyle Med. 2017 Nov 21;14(4):420-428. doi: 10.1177/1559827617742108. PMID: 33281522; PMCID: PMC7692018.

13.Unno N, Tanaka H, Suzuki M, Yamamoto N, Mano Y, Sano M, Saito T, Konno H. Influence of age and gender on human lymphatic pumping pressure in the leg. Lymphology. 2011 Sep;44(3):113-20. PMID: 22165581.

1.     Hablitz LM, Nedergaard M. The Glymphatic System: A Novel Component of Fundamental Neurobiology. J Neurosci. 2021 Sep 15;41(37):7698-7711. doi: 10.1523/JNEUROSCI.0619-21.2021. PMID: 34526407; PMCID: PMC8603752.

2.     Nilsson, O. (2019, 4 september). Strategiska miljoner till forskning om hjärnflöden. Umeå universitet. https://www.umu.se/nyheter/strategiska-miljoner-till-forskning-om-hjarnfloden_8312661/

3.     Lopes DM, Llewellyn SK, Harrison IF. Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system. Transl Neurodegener. 2022 Mar 21;11(1):19. doi: 10.1186/s40035-022-00293-2. PMID: 35314000; PMCID: PMC8935752.

4.     Licastro E, Pignataro G, Iliff JJ, Xiang Y, Lo EH, Hayakawa K, Esposito E. Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system. Commun Biol. 2024 Feb 24;7(1):229. doi: 10.1038/s42003-024-05911-5. PMID: 38402351; PMCID: PMC10894274.

5.     Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M. Circadian control of brain glymphatic and lymphatic fluid flow. Nat Commun. 2020 Sep 2;11(1):4411. doi: 10.1038/s41467-020-18115-2. PMID: 32879313; PMCID: PMC7468152.

6.     Corell, A., Jakola, A. S., & Skoglund, T. (2023, februari 8). Glymfatiska systemet – renar hjärnan från slaggprodukter: Störningar i systemet skulle kunna vara orsak till sjukdomar. Läkartidningen. https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2023/02/glymfatiska-systemet-renar-hjarnan-fran-slaggprodukter/

7.     Reddy OC, van der Werf YD. The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci. 2020 Nov 17;10(11):868. doi: 10.3390/brainsci10110868. PMID: 33212927; PMCID: PMC7698404.

8.     Sugama S, Kakinuma Y. Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response. Neurochem Int. 2021 Feb;143:104943. doi: 10.1016/j.neuint.2020.104943. Epub 2020 Dec 16. PMID: 33340593.

9.     Sriram S, Carstens K, Dewing W, Fiacco TA. Astrocyte regulation of extracellular space parameters across the sleep-wake cycle. Front Cell Neurosci. 2024 Jun 26;18:1401698. doi: 10.3389/fncel.2024.1401698. PMID: 38988660; PMCID: PMC11233815.

10.Bao C, Luo H, Wang J, Liu X, Li Y, Yang J, Chen C, Yang R, Ba W, Lian X, Dunk M, Liu J, Xu W. Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer’s disease: A DTI-ALPS study. J Prev Alzheimers Dis. 2025 Apr 11:100156. doi: 10.1016/j.tjpad.2025.100156. Epub ahead of print. PMID: 40221240.

11.Zhao X, Cao R, Tian X, Liu P, Liu D, Yu X, Zheng Z, Chen GL, Zou L. OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson’s Disease Model Mice Induced by Rotenone. Neurochem Res. 2025 Apr 12;50(2):142. doi: 10.1007/s11064-025-04388-w. PMID: 40220255.

12.Gong W, Zhai Q, Wang Y, Shen A, Huang Y, Shi K, Huang Y, Song M, Yan R, Yao Z, Lu Q. Glymphatic function and choroid plexus volume is associated with systemic inflammation and oxidative stress in major depressive disorder. Brain Behav Immun. 2025 Apr 11;128:266-275. doi: 10.1016/j.bbi.2025.04.008. Epub ahead of print. PMID: 40220922.

13.Chaganti JR, Talekar TK, Brew BJ. Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption. BMC Neurol. 2025 Mar 19;25(1):112. doi: 10.1186/s12883-025-04133-4. PMID: 40108491; PMCID: PMC11921593.

14.Wu L, Zhang Z, Liang X, Wang Y, Cao Y, Li M, Zhou F. Glymphatic system dysfunction in recovered patients with mild COVID-19: A DTI-ALPS study. iScience. 2023 Dec 7;27(1):108647. doi: 10.1016/j.isci.2023.108647. PMID: 38155770; PMCID: PMC10753064.

15.Che Mohd Nassir CMN, Che Ramli MD, Mohamad Ghazali M, Jaffer U, Abdul Hamid H, Mehat MZ, Hein ZM. The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease. Life (Basel). 2024 Dec 24;15(1):3. doi: 10.3390/life15010003. PMID: 39859943; PMCID: PMC11766513.

16.Johansson, B., Andréll, P., Mannheimer, C., & Rönnbäck, L. (2022). Hjärntrötthet – ett osynligt gissel: Möjliga förklaringar, diagnostik och möjliga behandlingar. Läkartidningen, 119, 21073. https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/vetenskapsradet/2022/03/hjarntrotthet–ett-osynligt-gissel/

17.Olegário RL, Nóbrega OT, Camargos EF. The newly discovered glymphatic system: the missing link between physical exercise and brain health? Front Integr Neurosci. 2024 Apr 16;18:1349563. doi: 10.3389/fnint.2024.1349563. PMID: 38690084; PMCID: PMC11058641.

18.Liu X, Hao J, Yao E, Cao J, Zheng X, Yao D, Zhang C, Li J, Pan D, Luo X, Wang M, Wang W. Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems. Brain Behav Immun. 2020 Oct;89:357-370. doi: 10.1016/j.bbi.2020.07.022. Epub 2020 Jul 24. PMID: 32717402.

19.Cheng Y, Liu X, Ma X, Garcia R, Belfield K, Haorah J. Alcohol promotes waste clearance in the CNS via brain vascular reactivity. Free Radic Biol Med. 2019 Nov 1;143:115-126. doi: 10.1016/j.freeradbiomed.2019.07.029. Epub 2019 Jul 27. PMID: 31362045.

20.Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Sci Rep. 2018 Feb 2;8(1):2246. doi: 10.1038/s41598-018-20424-y. PMID: 29396480; PMCID: PMC5797082.

Clark O. Lymphatic system. Publifye AS. 2025

2. Mora J.R., Iwata M., von Andrian U.H. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008:8;9. DOI: 10.1038/nri2378

3. van Gorkom G.N.Y., Klien Wolterink R.G.J., van Elssen C.H.M.J., et.al. Influence of Vitamin C on Lymphocytes: An Overview. Antioxidants 2018:7;3. DOI: https://doi.org/10.3390/antiox7030041

4. Honscheid A., Rink L., Haase H. T-Lymphocytes: A Target for Stimulatory and Inhibitory Effects of Zinc Ions. Endocrine, Metabolic & Immune Disorders-Drug Targets. 2009:9;2 DOI: https://doi.org/10.2174/187153009788452390

5. Treven P. Mrak V., Bogovic Matijasic B. et.al. Administration of probiotics Lactobacillus rhamnosus GG and Lactobacillus gasseri K7 during pregnancy and lactation changes mouse mesenteric lymph nodes and mammary gland microbiota. Journal of Dairy Science. 2015:98;4 DOI: https://doi.org/10.3168/jds.2014-8519

6. Teuwen L-A, Geldhof V., Carmeliet P. How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development. Develpmental Biology. 2019:447;1. DOI: https://doi.org/10.1016/j.ydbio.2017.12.001

7. Satoh Y., Kotani H., Iida Y., et.al. Supplementation of l-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy. The official journal of the Japanese Cancer Association. 2020:111;7 DOI: https://doi.org/10.1111/cas.14490

1.     Heald A, Perrin R, Walther A, Stedman M, Hann M, Mukherjee A, Riste L. Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention. Cardiovasc Endocrinol Metab. 2022 Apr 12;11(2):e0261.

2.     Hives L, Bradley A, Richards J, Sutton C, Selfe J, Basu B, Maguire K, Sumner G, Gaber T, Mukherjee A, Perrin RN. Can physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study. BMJ Open. 2017 Nov 13;7(11):e017521.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10045879/

https://www.cedars-sinai.org/blog/lymphatic-drainage-massage-faqs.html

https://www.self.com/story/facial-lymphatic-drainage-massage

1.Salonen JT, Seppänen K, Rauramaa R, Salonen R. Risk factors for carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Med. 1989 Jun;21(3):227-9.

2.Engström Å, Hägglund H, Lee E, Wennberg M, Söderberg S, Andersson M. Sauna bathing in northern Sweden: results from the MONICA study 2022. Int J Circumpolar Health. 2024 Dec;83(1):2419698.

Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium – positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024 May 7;22(1):191.

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2. Sellem L, Srour B, Javaux G, Chazelas E, Chassaing B, Viennois E, Debras C, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Arnault N, Agaësse C, De Sa A, Lutchia R, Huybrechts I, Scalbert A, Pierre F, Coumoul X, Julia C, Kesse-Guyot E, Allès B, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Santé cohort. PLoS Med. 2024 Feb 13;21(2):e1004338.

2. Kavanaugh M, Rodgers D, Rodriguez N, Leroy F. Considering the nutritional benefits and health implications of red meat in the era of meatless initiatives. Front Nutr. 2025 Jan 27;12:1525011.

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1525011/full

4. You W, Henneberg R, Saniotis A, Ge Y, Henneberg M. Total Meat Intake is Associated with Life Expectancy: A Cross-Sectional Data Analysis of 175 Contemporary Populations. Int J Gen Med. 2022 Feb 22;15:1833-1851.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8881926/